Unlock instant, AI-driven research and patent intelligence for your innovation.

A kind of plant cellulose soft capsule rubber and preparation method thereof

A plant cellulose and soft capsule technology, applied in capsule delivery, pharmaceutical formulations, medical preparations of non-active ingredients, etc., can solve the problems of inability to guarantee rapid release and absorption of capsule contents, secondary injury to patients, and reduced disintegration efficiency and other issues, to achieve the effects of preventing the risk of unknown viruses, rapid release and absorption, and shortened disintegration time

Active Publication Date: 2021-02-23
广东广发制药有限公司
View PDF5 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the soft capsule glue prepared from the above gelatin has the following defects: (1) the use of gelatin prepared from unhealthy or unidentified animals can easily introduce unknown pathogenic viruses into the drug, causing secondary injury or infection to the patient, such as mad cow disease, Swine fever, swine flu virus, etc.
Chinese patent application CN109619250A discloses a plant rubber type seaweed powder gel candy, wherein the plant rubber is composed of the following components and parts by weight: 1-2.5 parts of carrageenan, 5-15 parts of starch, 2- 8 parts, 0.4-1 part of glycerin, 4-8 parts of sweetener, 1-5 parts of microcrystalline cellulose, 32-65 parts of water, although the rubber prepared by this invention does not use gelatin, it can avoid mad cow disease and poisonous capsule incidents, etc. problem, but its disintegration speed is slow, which cannot guarantee the rapid release and absorption of the capsule contents in the body, and after long-term storage, the disintegration efficiency decreases

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Embodiment 1 A kind of plant cellulose soft capsule rubber

[0035] The vegetable cellulose soft capsule rubber is composed of the following components in parts by weight:

[0036] 72.2 parts of purified water, 20 parts of methyl cellulose, 0.8 part of carrageenan, 0.05 part of sorbic acid, 0.05 part of titanium dioxide, and 0.05 part of pigment.

[0037] A preparation method for plant cellulose soft capsule rubber, comprising the following preparation steps:

[0038] Step 1. Put 60 parts of purified water into the plastic tank;

[0039] Step 2, adding sorbic acid to 10 times the volume of ethanol aqueous solution to dissolve, and then adding it to the glue tank;

[0040] Step 3, dissolving titanium dioxide in 10 parts of purified water and grinding it with a colloid mill, passing it through an 80-mesh sieve for later use;

[0041] Step 4: After dissolving the pigment in 2.2 parts of purified water, add the titanium dioxide suspension prepared in Step 3 and stir even...

Embodiment 2

[0046] Embodiment 2 A kind of plant cellulose soft capsule rubber

[0047] The vegetable cellulose soft capsule rubber is composed of the following components in parts by weight:

[0048] 76.2 parts of purified water, 22.5 parts of ethyl cellulose, 1 part of xanthan gum, 0.1 part of sorbic acid, 0.1 part of titanium dioxide, and 0.1 part of pigment.

[0049] A preparation method for plant cellulose soft capsule rubber, comprising the following preparation steps:

[0050] Step 1. Put 65 parts of purified water into the plastic tank;

[0051] Step 2, adding sorbic acid into an aqueous ethanol solution whose volume is 10 times the amount for dissolving, and then adding it into the glue tank;

[0052] Step 3, dissolving titanium dioxide in 8 parts of purified water and grinding it with a colloid mill, passing through a 90-mesh sieve for subsequent use;

[0053] Step 4: After dissolving the pigment in 3.2 parts of purified water, add the titanium dioxide suspension prepared in S...

Embodiment 3

[0058] Embodiment 3 A kind of plant cellulose soft capsule rubber

[0059] The vegetable cellulose soft capsule rubber is composed of the following components in parts by weight:

[0060] 80.2 parts of purified water, 25 parts of powdered cellulose, 1.2 parts of sodium alginate, 0.15 parts of sorbic acid, 0.15 parts of titanium dioxide, and 0.15 parts of pigment.

[0061] A preparation method for plant cellulose soft capsule rubber, comprising the following preparation steps:

[0062] Step 1. Put 60 parts of purified water into the plastic tank;

[0063] Step 2, adding sorbic acid into an aqueous ethanol solution whose volume is 10 times the amount for dissolving, and then adding it into the glue tank;

[0064] Step 3, dissolving titanium dioxide in 15 parts of purified water and grinding it with a colloid mill, passing through a 100-mesh sieve for subsequent use;

[0065] Step 4: After dissolving the pigment in 5.2 parts of purified water, add the titanium dioxide suspensi...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
viscosityaaaaaaaaaa
thicknessaaaaaaaaaa
thicknessaaaaaaaaaa
Login to View More

Abstract

The invention belongs to the technical field of soft capsule rubber preparation, and in particular relates to a plant cellulose soft capsule rubber and a preparation method thereof. The plant cellulose soft capsule rubber provided by the present invention comprises the following components and parts by weight: 72.2-80.2 parts of purified water, 20-25 parts of plant cellulose, 0.8-1.2 parts of gelling agent, 0.05-0.15 parts of preservative, 0.05-0.15 part of sunscreen, 0.05-0.15 part of pigment. The soft capsule rubber prepared by the plant cellulose provided by the present invention uses plant components instead of animal components, which reduces the safety hazards of animal products compared with traditional gelatin soft capsules; and the disintegration time is significantly shortened, ensuring the stability of the capsule in the stomach. Rapid release, and the disintegration time limit of the soft capsule will not change due to the length of storage time.

Description

technical field [0001] The invention belongs to the technical field of soft capsule rubber preparation, and in particular relates to a method for plant cellulose soft capsule rubber. Background technique [0002] Soft capsule refers to the liquid or molten drug mixture containing certain active ingredients, or the solution, suspension, emulsion or semi-solid (paste, etc.) mixture containing solid drug dispersion, sealed in a spherical or oval shape. Capsules with soft capsules. Among them, the rubber has been made of animal pig or cow skin or bones, gelatin made by acidification or alkalization, and then formulated with water, glycerin and other auxiliary materials. However, the soft capsule glue prepared from the above gelatin has the following defects: (1) the use of gelatin prepared from unhealthy or unidentified animals can easily introduce unknown pathogenic viruses into the drug, causing secondary injury or infection to the patient, such as mad cow disease, swine fev...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/48A61K47/38
CPCA61K9/4816A61K47/38
Inventor 黄斌李渡春钟耀清曾启谊周树和
Owner 广东广发制药有限公司