Titanium alloy implant biological surface active coating and preparation method thereof

A biological surface and active coating technology, applied in the direction of surface reaction electrolytic coating, coating, electrolytic coating, etc., to improve the quality of the film layer, enhance biological activity, and enhance the effect of protein adsorption

Inactive Publication Date: 2019-12-03
GUANGDONG INST OF NEW MATERIALS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The following problems exist in the application of micro-arc oxidation technology to the surface modification of 3D printed titanium alloy implants: (1) The structure of titanium alloy prepared by selective laser melting 3D printing technology is quite different from that of traditional casting or forging, which requires systematic Explore matching micro-arc oxidation process parameters and electrolyte formulations

Method used

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  • Titanium alloy implant biological surface active coating and preparation method thereof
  • Titanium alloy implant biological surface active coating and preparation method thereof
  • Titanium alloy implant biological surface active coating and preparation method thereof

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Experimental program
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Embodiment 1

[0034] An embodiment of the titanium alloy implant biological surface active coating of the present invention, the titanium alloy implant biological surface active coating described in this embodiment is prepared by the following method:

[0035] The titanium alloy implant is placed in the electrolyte, the titanium alloy implant is used as the anode, and the electrolytic cell is used as the cathode. A bioactive micro-arc oxidation coating is formed on the surface;

[0036] The formula of the electrolyte is: sodium hydroxide 0.2mol / L, sodium dihydrogen phosphate 0.04mol / L, disodium oxalate tetraacetate 0.015mol / L, calcium acetate 0.1mol / L, nano-hydroxyapatite 1g / L , the solvent is deionized water.

[0037] The parameters of the micro-arc oxidation process are as follows: the micro-arc oxidation voltage is 300V, the frequency is 500Hz, the positive and negative duty cycles are +35% and -15%, respectively, and the processing time is 5min.

[0038] as attached figure 1 As shown...

Embodiment 2

[0044] A kind of embodiment of biological surface active coating of titanium alloy implant of the present invention, the preparation method of biological surface active coating of titanium alloy implant described in this embodiment is the same as embodiment 1, wherein,

[0045] The formula of the electrolyte is: sodium hydroxide 0.1mol / L, sodium dihydrogen phosphate 0.03mol / L, disodium oxalate tetraacetate 0.01mol / L, calcium acetate 0.01mol / L, nano-hydroxyapatite 0.5g / L L, the solvent is deionized water.

[0046] The parameters of the micro-arc oxidation process are as follows: the micro-arc oxidation voltage is 250V, the frequency is 700Hz, the positive and negative duty cycles are +55% and -35%, respectively, and the processing time is 10min.

Embodiment 3

[0048] A kind of embodiment of biological surface active coating of titanium alloy implant of the present invention, the preparation method of biological surface active coating of titanium alloy implant described in this embodiment is the same as embodiment 1, wherein,

[0049] The formula of the electrolyte is: sodium hydroxide 0.3mol / L, sodium dihydrogen phosphate 0.08mol / L, disodium oxalate tetraacetate 0.05mol / L, calcium acetate 0.5mol / L, nano-hydroxyapatite 3g / L , the solvent is deionized water.

[0050] The parameters of the micro-arc oxidation process are as follows: the micro-arc oxidation voltage is 350V, the frequency is 500Hz, the positive and negative duty ratios are +75% and -55%, respectively, and the processing time is 15min.

[0051] The present invention has carried out X-ray energy spectrum (XRD) analysis to the porous implant after above-mentioned case processing, specifically as attached figure 2 As shown, it was found that there were different crystal fo...

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Abstract

The invention discloses a preparation method of a titanium alloy implant biological surface active coating. The method comprises the steps of placing the titanium alloy implant in the electrolyte, taking the titanium alloy implant as an anode and an electrolytic cell as a cathode, controlling the temperature of the electrolyte not to be larger than 40 DEG C, adopting a pulse power source for a micro-arc oxidation process, and forming a micro-arc oxidation coating with biological activity on the surface of the titanium alloy implant. According to the present invention, the porous titanium alloyimplant is prepared through a selective laser melting 3D printing technology, and a coating with biological activity is generated on the surface of the titanium alloy porous implant in situ, so thatthe protein adsorption, cell adsorption and cell proliferation capabilities of the surface of the customized porous implant are remarkably enhanced, and the new bone ingrowth capability of the titanium alloy porous implant after an implantation operation is improved.

Description

technical field [0001] The invention relates to a biological surface active coating and a preparation method thereof, in particular to a 3D printing porous titanium alloy implant biological surface active coating and a preparation method thereof, which can be widely used in orthopedics, spine and trauma in the medical industry departments and other fields. Background technique [0002] Selective laser melting 3D printing technology has gradually matured in the manufacture of titanium alloys. Taking advantage of the advantages of high-precision integral molding of 3D printing technology, porous titanium alloy implants with controllable pore size and porosity can be prepared. Since the molding is carried out under a protective atmosphere, the mechanical properties of the implant are also taken into consideration while ensuring the material properties of the implant. However, the material properties of titanium alloy determine that the surface of porous titanium alloy is bioin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C25D11/26A61L27/06A61L27/32A61L27/56
CPCA61L27/06A61L27/32A61L27/56A61L2430/02C25D11/024C25D11/026C25D11/26
Inventor 闫星辰刘敏马文有廖汉林
Owner GUANGDONG INST OF NEW MATERIALS
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