Synthesis method of hesperetin dihydrochalcone

A technology of hesperetin dihydrochalcone and dihydrochalcone, which is applied in the field of synthesis of hesperetin dihydrochalcone, can solve the problem of the lack of research on the synthesis process of hesperetin dihydrochalcone and the lack of resources In order to achieve the effect of easy access, abundant sources and pure taste

Inactive Publication Date: 2019-12-10
SHAANXI JIAHE PHYTOCHEM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is very little research on the synthesis process of hesperetin dihydrochalcone, and resources are scarce. At present, a synthesis process with simple process, high yield and high content has not been found for direct use by manufacturers.

Method used

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  • Synthesis method of hesperetin dihydrochalcone

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] A kind of synthetic method of hesperetin dihydrochalcone, comprises the following steps:

[0034] 1) Preparation of hesperidin dihydrochalcone

[0035] Add 1000 g of sodium hydroxide solution with a mass concentration of 5% to 100 g of raw material hesperidin, then add 3 g of Raney nickel catalyst, stir evenly, heat up to 40 ° C, and carry out hydrogenation reaction for 3 hours to obtain hesperidin containing A solution of dihydrochalcone;

[0036] 2) Preparation of crude hesperetin dihydrochalcone

[0037] Use hydrochloric acid to adjust the pH of the solution containing hesperidin dihydrochalcone to 2, raise the temperature and reflux for 5 hours to completely hydrolyze, cool down to below 10°C, crystallize for 24 hours, suction filter and dry to obtain hesperetin dihydrochalcone Crude.

[0038] Step 3) prepare hesperetin dihydrochalcone boutique

[0039] The hesperetin dihydrochalcone crude product obtained in step 2) was recrystallized with 50% ethanol at 10 tim...

Embodiment 2

[0041] A kind of synthetic method of hesperetin dihydrochalcone, comprises the following steps:

[0042] 1) Preparation of hesperidin dihydrochalcone

[0043] Add 1200g of sodium hydroxide solution with a mass concentration of 8% to 100g of raw material hesperidin, then add 3g of Raney nickel catalyst, stir evenly, heat up to 45°C, carry out hydrogenation reaction for 3h, and obtain hesperidin containing A solution of dihydrochalcone;

[0044] 2) Preparation of crude hesperetin dihydrochalcone

[0045] Use hydrochloric acid to adjust the pH of the solution containing hesperidin dihydrochalcone to 3, raise the temperature and reflux for 5 hours to completely hydrolyze, cool down to below 10°C, crystallize for 24 hours, suction filter and dry to obtain hesperetin dihydrochalcone Crude;

[0046] Step 3) prepare hesperetin dihydrochalcone boutique

[0047] The hesperetin dihydrochalcone crude product obtained in step 2) was recrystallized with 55% ethanol with 12 times its vol...

Embodiment 3

[0049] A kind of synthetic method of hesperetin dihydrochalcone, comprises the following steps:

[0050] 1) Preparation of hesperidin dihydrochalcone

[0051] Add 550 g of potassium hydroxide solution with a mass concentration of 10% to 50 g of raw material hesperidin, then add 1.5 g of Raney nickel catalyst, stir evenly, heat up to 42 ° C, and carry out hydrogenation reaction for 3 hours to obtain orange peel A solution of the glycoside dihydrochalcone;

[0052] 2) Preparation of crude hesperetin dihydrochalcone

[0053] Use hydrochloric acid to adjust the pH of the solution containing hesperidin dihydrochalcone to 3, raise the temperature and reflux for 5 hours to completely hydrolyze, cool down to below 10°C, crystallize for 24 hours, suction filter and dry to obtain hesperetin dihydrochalcone Crude;

[0054] Step 3) prepare hesperetin dihydrochalcone boutique

[0055] The hesperetin dihydrochalcone crude product obtained in step 2) was recrystallized with 15 times the ...

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Abstract

The invention provides a synthesis method of hesperetin dihydrochalcone. The synthesis method gets rid of the dilemma that no document records a hesperetin dihydrochalcone synthesis related process which can be used for reference by manufacturers. A one-pot method is adopted, hesperidin is taken as a starting raw material to be placed into a sodium hydroxide solution or a potassium hydroxide solution for catalytic hydrogenation to prepare hesperidin dihydrochalcone, then acid is added for neutralization, and hydrolysis is conducted under the acid condition to obtain the hesperetin dihydrochalcone.

Description

technical field [0001] The invention belongs to the technical field of food additives, in particular to a method for synthesizing hesperetin dihydrochalcone. Background technique [0002] Due to the increasing proportion of diabetics in the world, the demand for sugar in the human diet is constantly undergoing new changes, and the exploration of natural low-calorie sweeteners is constantly deepening. Health provides security. Healthy and natural low-calorie sweeteners are extracted from plants and produced by biological methods or simple reduction reactions. They have good taste, low additions, and low calories. They can not only satisfy people's pursuit of sweetness, but also reduce the risk of excessive The health hazards caused by ingesting sugar, therefore, natural low-calorie sweeteners are safe, easy to accept by consumers, and are very popular in the market. At present, natural high-intensity sweeteners mainly include stevioside, glycyrrhizin, mogroside, aspartame, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C45/64C07C49/84
CPCC07C45/64C07H1/00C07H15/203C07C49/84
Inventor 郭文华肖金霞赵景辉徐恒伟郭良韦博
Owner SHAANXI JIAHE PHYTOCHEM
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