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A Malassezia inhibitor technology, applied in the field of Malassezia inhibitors, can solve the problems of drug resistance and irritation, and achieve high safety and wide application potential
Active Publication Date: 2019-12-20
武汉禾本泰医药科技有限公司
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Therefore, in anti-dandruff daily chemical products and cosmetics, people mainly focus on the research and development of anti-Malassezia active drugs, such as ketoconazole, climbazole, and zinc pyrithione are recognized as effective Anti-Malassezia and anti-dandruff drugs, but these drugs are more irritating, and long-term use will produce drug resistance
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Embodiment 1
[0009] Take caddis worm, add water to decoct and extract twice, each time for 2 hours, collect the extract, concentrate, dry, grind into fine powder, and obtain caddis worm water extract.
Embodiment 2
[0011] Take caddisiworm, extract twice with ethanol with a volume concentration of 50%, 70%, and 90% under reflux, each time for 2 hours, collect the extract, concentrate, dry, and pulverize into fine powder to obtain three caddisols Extract.
Embodiment 3
[0013] 1) Dissolving the water extract and the alcohol extract of Cadida praecox in sterile water respectively to prepare a liquid to be tested with a solid content of 0.05 g / ml;
[0014] 2) The purchased Malassezia furfur was activated and cultured, and the concentration was 10% with sterile water. 7 cfu / ml bacterial suspension;
[0015] 3) Pour the olive oil medium onto the plate, cool and solidify, take 500 μl of Malassezia suspension in the medium, spread it evenly and dry it for 15 minutes;
[0016] 4) Place 3 Oxford cups above the petri dish, inject the same drug solution to be tested into the 3 Oxford cups as three parallels, use sterile water as a negative control, and zinc pyrithione (ZPT) as a positive control.
[0017] 5) Put the petri dish into a 37° C. incubator for constant temperature incubation for 48 hours, then take it out, observe whether there is a bacteriostatic zone and measure the diameter with a vernier caliper.
[0018] As a result, it was found that...
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Abstract
The present invention discloses a malassezia inhibitor. Results of in vitro microorganism-inhibiting tests show that an extract of stachys sieboldii has a significant inhibitory effect on malassezia and is an excellent malassezia inhibitor. The malassezia inhibitor can be used to treat skin diseases of tinea versicolor, folliculitis, seborrheic dermatitis, etc., can also be developed into anti-dandruff daily chemical products or cosmetics, has a wide range of application potentials, and also has very high safety due to being derived from natural plants.
Description
technical field [0001] The present invention relates to a Malassezia inhibitor. Background technique [0002] Grass stone silkworm (Stachys sieboldii Miq.) is a perennial herbaceous plant belonging to Labiatae, Stachys genus. Because its underground stem is shaped like a silkworm chrysalis or a screw, it is also called screw vegetable, pagoda vegetable, manna seed, ground silkworm, etc. The medicinal part of chrysalis is the rhizome, which is recorded in "Compendium of Materia Medica" and "Luchuan Materia Medica". It is sweet in taste and flat in nature. Treatment of colds, fatigue, cough, jaundice, stranguria, sores, swelling and pain. [0003] Malassezia is a resident bacterium on the surface of the skin, and it is also the pathogen of tinea versicolor and folliculitis. Important cause of scalp seborrheic dermatitis (dandruff). Therefore, in anti-dandruff daily chemical products and cosmetics, people mainly focus on the research and development of anti-Malassezia active...
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