Preparation method of biomolecule terahertz sensor chip of universal nano-scale fluid and application thereof

A biomolecule and sensor chip technology, applied in the field of biosensors, can solve the problems of high absorption liquid sensing difficulty and low detection sensitivity, and achieve the effect of improving detection sensitivity and increasing detection efficiency

Pending Publication Date: 2019-12-20
张阳
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Problems solved by technology

[0005] The purpose of the present invention is to provide a method for preparing a biomolecular terahertz sensor chip for general-purpose na

Method used

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  • Preparation method of biomolecule terahertz sensor chip of universal nano-scale fluid and application thereof
  • Preparation method of biomolecule terahertz sensor chip of universal nano-scale fluid and application thereof
  • Preparation method of biomolecule terahertz sensor chip of universal nano-scale fluid and application thereof

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Embodiment Construction

[0026] The following is combined with the specific implementation Figure 1-6 To elaborate further:

[0027] A method for preparing a biomolecular terahertz sensor chip for general-purpose nanoscale fluids, comprising the following steps:

[0028] (1) Fabrication of SRRs metamaterials

[0029] a. Substrate substrate cleaning: Put the cut silicon wafer into an ultrasonic cleaner for cleaning. After taking it out, first clean it with absolute ethanol and then rinse it with deionized water, then dry the surface of the silicon wafer with high-pressure nitrogen, and then Put into drying box; b. Coating: plate the gold film that thickness is 120nm on the channel surface; C. Coating: photoresist (SU-8) is evenly spin-coated on the surface of gold film, put into drying box to dry Dry, cool naturally in a dark room; d. Exposure: Use an exposure machine to perform periodic structural unit exposure on a uniformly coated surface (for the structure see figure 1 ); the unit structure is ...

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Abstract

The application of the invention belongs to the technical field of biosensors, and specifically discloses preparation method of a biomolecule terahertz sensor chip of a universal nano-scale fluid andits use in liquid-phase sensing of biological macromolecules, and the preparation method comprises the following steps of (1) making silicon wafers into SRRs metamaterials for future use; (2) selecting silicon wafers, and manufacturing PDMS channels on the silicon wafers; (3) bonding the SRRs metamaterials in the step (1) and the PDMS channels in the step (2) to prepare a terahertz sensor chip; (4) detecting a variety of highly absorbent liquids; and (5) detecting oxidized low-density lipoprotein at different concentrations. The invention is mainly used for preparing the terahertz sensor chipand performing sensing of a superabsorbent solution by using the terahertz sensor chip, solves the big difficulty of sensing high-absorbent liquids in the terahertz field, has low detection sensitivity, and realizes the detection of biological macromolecules in a liquid phase environment.

Description

technical field [0001] The invention belongs to the technical field of biosensors, and specifically discloses a method for preparing a biomolecular terahertz sensor chip of a universal nanoscale fluid. Background technique [0002] Terahertz waves are electromagnetic waves with a frequency between 0.1 and 10 THz. Based on THz, it is possible to perform label-free, non-contact and non-destructive detection of biological substances. The weak interactions between nucleic acid, protein and other biomacromolecules (such as hydrogen bonds, van der Waals forces, etc.), skeleton vibration and dipole rotation are just in the THz spectrum range, and each biomacromolecule has a specific THz spectrum fingerprint. Therefore, THz waves can detect information about the composition, structure and function of biological macromolecules that cannot be obtained in other electromagnetic bands. THz waves can reveal the structural and functional information of multiple biomacromolecules at the sa...

Claims

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Application Information

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IPC IPC(8): G01N21/3586B81C1/00
CPCG01N21/3586B81C1/00055B81B2201/0214B81B2201/05
Inventor 张阳谢明真府伟灵
Owner 张阳
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