Method for detecting a plurality of small molecular chemical components in Xuebijing injection

A technology of chemical composition and detection method, applied in the field of analysis of pharmaceutical composition, can solve the problem of lack of comprehensive quantitative/semi-quantitative detection of Xuebijing Injection
CN110632230AActive Publication Date: 2019-12-31SHANGHAI INST OF MATERIA MEDICA CHINESE ACAD OF SCI +1
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
SHANGHAI INST OF MATERIA MEDICA CHINESE ACAD OF SCI
Publication Date
2019-12-31

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Abstract

The invention provides a method for detecting a plurality of small molecular chemical components in a Xuebijing injection. The method comprises the following steps: step one, preparing a sample solution; step two, preparing a first standard solution; step three, preparing a second standard solution; and step four, carrying out measurement on the sample solution, the first standard solution and thesecond standard solution by using a high performance liquid chromatography-mass spectrometry method, quantifying 57 kinds of small molecule chemical components in the sample solution by using a standard curve method and then determining contents of other 66 kinds of small molecule chemical components with structures similar to those of the 57 small molecule chemical components that are determinedin a quantified mode in a semi-quantitative manner. According to the method provided by the invention, 123 traditional Chinese medicine small molecule compounds can be quantitatively or semi-quantitatively detected with high flux and high sensitivity and a key technical way is provided for optimizing the preparation process of Xuebijing and improving the product quality uniformity.
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Description

technical field

[0001] The invention belongs to the technical field of analysis of medicinal components, and relates to a method for detecting multiple small molecule chemical components in Xuebijing injection, in particular to a method for simultaneously detecting 123 small molecule chemical components in Xuebijing injection method. Background technique

[0002] Sepsis is an organ dysfunction syndrome resulting from a systemic host response to infection and is characterized by high lethality (25-50%) and a poor prognosis. The conventional treatment of sepsis (including septic shock) mainly relies on timely and reasonable antibiotic anti-infection treatment and regulation of abnormal response of patients, but there is still a lack of effective chemical drugs for the latter. Xuebijing, a traditional Chinese medicine injection, is currently the only Class II new drug of traditional Chinese medicine approved for the treatment of sepsis in China (2004). About 600,000 sepsis pat...

Claims

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