Nefopam hydrochloride tablet and preparation method thereof

A Nefopam Hydrochloride Tablet and Nefopam Hydrochloride Technology, which is applied in the direction of pharmaceutical formulas, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problem of affecting the efficacy of medicines, and Nefopam Hydrochloride Tablets. Coating treatment, poor quality control of the processing process, etc., to achieve the effect of consistency guarantee

Inactive Publication Date: 2020-01-03
HUAYI PHARMA ANHUI CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In order to solve the problem that the existing Nefopam Hydrochloride Tablets are not coated, the quality of the processing process is not easy to control, and the produced Nefopam Hydrochloride Tablets are easily contaminated, which affects the efficacy of the medicine. The purpose of the present invention is to provide a A kind of Nefopam hydrochloride tablet and preparation method thereof

Method used

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  • Nefopam hydrochloride tablet and preparation method thereof

Examples

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Effect test

Embodiment 1

[0027] Embodiment 1, a kind of Nefopam hydrochloride tablet, is made of the raw material of following parts by weight:

[0028] 30 parts of calcium hydrogen phosphate dihydrate, 25 parts of microcrystalline cellulose, 1 part of hypromellose, 1 part of anhydrous silica gel, 1 part of magnesium stearate, 10 parts of Nefopam hydrochloride, 2 parts of white Opadry 20A58806 .

[0029] Preferably, include the following steps:

[0030] S1, preparing calcium hydrogen phosphate dihydrate, microcrystalline cellulose, hypromellose, anhydrous silica gel, magnesium stearate, Nefopam hydrochloride, and white Opadry 20A58806 according to the proportion by weight;

[0031] S2, putting calcium hydrogen phosphate dihydrate, microcrystalline cellulose, and Nefopam hydrochloride into a high-efficiency wet granulator, stirring, and then adding hypromellose and purified water to granulate;

[0032] S3, after the granulation is completed, put it into a drier for drying, and sieve it on a granulato...

Embodiment 2

[0042] Embodiment 2, a kind of Nefopam hydrochloride tablet, is made of the raw material of following parts by weight:

[0043] 40 parts of calcium hydrogen phosphate dihydrate, 30 parts of microcrystalline cellulose, 3 parts of hypromellose, 5 parts of anhydrous silica gel, 3 parts of magnesium stearate, 30 parts of Nefopam hydrochloride, 15 parts of white Opadry 20A58806 .

[0044] Include the following steps:

[0045] S1, preparing calcium hydrogen phosphate dihydrate, microcrystalline cellulose, hypromellose, anhydrous silica gel, magnesium stearate, Nefopam hydrochloride, and white Opadry 20A58806 according to the proportion by weight;

[0046] S2, putting calcium hydrogen phosphate dihydrate, microcrystalline cellulose, and Nefopam hydrochloride into a high-efficiency wet granulator, stirring, and then adding hypromellose and purified water to granulate;

[0047] S3, after the granulation is completed, put it into a drier for drying, and sieve it on a granulator to obt...

Embodiment 3

[0057] Embodiment 3, a kind of Nefopam hydrochloride tablet, is made of the raw material of following parts by weight:

[0058] 50 parts of calcium hydrogen phosphate dihydrate, 50 parts of microcrystalline cellulose, 5 parts of hypromellose, 6 parts of anhydrous silica gel, 3 parts of magnesium stearate, 30 parts of Nefopam hydrochloride, 15 parts of white Opadry 20A58806 .

[0059] Include the following steps:

[0060] S1, preparing calcium hydrogen phosphate dihydrate, microcrystalline cellulose, hypromellose, anhydrous silica gel, magnesium stearate, Nefopam hydrochloride, and white Opadry 20A58806 according to the proportion by weight;

[0061] S2, putting calcium hydrogen phosphate dihydrate, microcrystalline cellulose, and Nefopam hydrochloride into a high-efficiency wet granulator, stirring, and then adding hypromellose and purified water to granulate;

[0062] S3, after the granulation is completed, put it into a drier for drying, and sieve it on a granulator to obt...

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Abstract

The invention discloses a nefopam hydrochloride tablet and relates to the technical field of pharmaceutical preparation. The nefopam hydrochloride tablet is prepared from the following raw materials in parts by weight: 30-50 parts of dicalcium phosphate dihydrate, 25-50 parts of microcrystalline cellulose, 1-5 parts of hydroxypropyl methylcellulose, 1-8 parts of anhydrous silica gel, 1-6 parts ofmagnesium stearate, 10-38 parts of nefopam hydrochloride and 2-20 parts of white Opadry 20A58806. According to the nefopam hydrochloride tablet, the problems that an existing nefopam hydrochloride tablet is not coated, the quality of the processing process is not well controlled, the produced nefopam hydrochloride tablet is prone to being polluted, and consequently, the drug efficacy is affected are solved.

Description

technical field [0001] The invention relates to the technical field of medicine preparation, in particular to a nefopam hydrochloride tablet and a preparation method thereof. Background technique [0002] Nefopam Hydrochloride Tablets Nefopam Hydrochloride Tablets is a new type of non-narcotic analgesic with mild antipyretic and muscle relaxant effects. The chemical structure belongs to cyclized o-methyldiphenhydramine. Therefore, it does not have the characteristics of non-steroidal anti-inflammatory drugs, nor is it an opioid receptor agonist. It is effective for moderate and severe pain, and has a mild effect on respiratory depression. No inhibitory effect on the circulatory system. No tolerance and dependence. [0003] In the prior art, Nefopam Hydrochloride Tablets are not coated, the quality of the processing process is not well controlled, and the produced Nefopam Hydrochloride Tablets are easily contaminated, which affects the efficacy of the drug. Contents of ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/36A61K47/02A61K47/38A61K47/04A61K47/12A61K31/395A61P29/00
CPCA61K9/2009A61K9/2013A61K9/2054A61K9/2866A61K31/395A61P29/00
Inventor 高煜
Owner HUAYI PHARMA ANHUI CO LTD
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