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Preparation method of capsules

A technology of capsules and traditional Chinese medicine, which is applied in the field of capsule preparation and can solve problems such as different curative effects

Pending Publication Date: 2020-01-03
广东南芯医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The inventors have found that the same Chinese herbal medicine has different curative effects on different individuals

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] Codonopsis Codonopsis is a herbal medicine included in the "Chinese Pharmacopoeia". The source of herbal medicine is the dried root of Codonopsis Codonopsis, Suhua Codonopsis, or Sichuan Codonopsis. The main active ingredients of Codonopsis Codonopsis are polysaccharides, glycosides, sterols, volatile oils and alkaloids. Thirst and other symptoms. Codonopsis polysaccharide has the active effects of enhancing animal immunity, promoting hematopoietic function and anti-oxidation. Codonopsis saponins can exert pharmacological effects such as antitumor, antibacterial and inhibiting the expression of related inflammatory factors under the metabolism of intestinal flora. When Supriya R. et al. studied the effect of Codonopsis saponins on 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis in mice, they found that Codonopsis saponins A was mainly metabolized by intestinal flora It is a secondary saponin active small molecular substance, which is then absorbed by intesti...

Embodiment 2

[0062] Ginseng is a perennial herbaceous plant of Araliaceae, which mainly grows in cold regions. It is known as the "King of Herbs" and is a traditional and precious traditional Chinese medicinal material well-known both at home and abroad. Red ginseng is the most common processed product of ginseng, which is made through processes such as infiltration, cleaning, sorting, steaming, drying, and drying. Red ginseng contains a variety of rare saponins, such as ginsenoside Rg 3 , Rg 5 、Rk 1 have significant pharmacological activity. A large number of studies have shown that ginsenosides form aglycones or subglycosides to exert pharmacological effects after desugar metabolism in the gastrointestinal tract. These components are more easily absorbed by the gastrointestinal tract, and their activity is stronger than that of saponins.

[0063] Guo et al found through in vitro experiments that both can promote the growth of two probiotics, Lactobacillus and Bifidobacterium, and red ...

Embodiment 3

[0081] The active ingredients of Polygonum cuspidatum are mainly stilbenes and anthraquinones. The former is mainly resveratrol and its glycosides, and the latter is mainly emodin and its glycosides. Among them, stilbenes have remarkable and unique effects. It is reported that the content of resveratrol in dried Polygonum cuspidatum rhizome is 0.1%-0.2%, and the content of polydatin is about 2%. Polydatin can be decomposed by glycosidase in the intestinal tract to release resveratrol and exert pharmacological effects. Resveratrol has anti-tumor, anti-oxidation, anti-free radical, anti-thrombotic, anti-allergic, anti-atherosclerosis and has the prevention and treatment of coronary heart disease, ischemic heart disease, hyperlipidemia, resveratrol has been Listed as one of the most promising anti-cardiovascular disease and anti-cancer drugs. In addition to the free part, emodin, another active ingredient in Polygonum cuspidatum, still has a part connected in the form of β-glucos...

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Abstract

The invention relates to a preparation method of capsules. Fecal microbiota transplantation (FMT) is that functional florae in feces of healthy people are transplanted into the gastrointestinal tractsof patients, new intestinal tract florae are reconstructed, and intestinal diseases and extra-intestinal diseases are treated. It is clinically found that the required curative effects cannot be achieved after the certain patients take radix codonopsis, and one of main reasons resulting in the individual difference is that due to missing and insufficiency of the intestinal tract florae of the patients, the radix codonopsis cannot be normally decomposed and converted into active components, and consequently, the required curative effects of the radix codonopsis cannot be exerted. Healthy high-quality feces of FMT donors is utilized to simulate the enzymolysis of intestinal microorganisms on radix codonopsis saponins in vitro, tangshenoside in traditional Chinese medicines such as the radixcodonopsis is degraded and converted into secondary saponin active small-molecular substances through the appropriate fermentation condition, and then the drug efficacy is exerted. Meanwhile, in thefermentation process, fructo-oligosaccharide, radix codonopsis polysaccharides and the radix codonopsis saponins exert the effect of improving intestinal microecology, and thus conversion of the active components of the radix codonopsis is facilitated to form a virtuous circle. The fecal microbiota capsules are prepared from fecal microbiota fermentation liquid and used for clinical FMT treatment.

Description

technical field [0001] The application belongs to the fields of human fecal bacteria transplantation, fermentation and traditional Chinese medicine, and relates to a preparation method of capsules. Background technique [0002] Chinese herbal medicines have certain curative effects. Some Chinese herbal medicines may be used to strengthen the body, or to treat diseases. [0003] The inventors have found that the same Chinese herbal medicine has different curative effects on different individuals. Therefore, there is a need for a method that can promote the absorption of corresponding Chinese herbal medicines by the human body and improve the average curative effect of Chinese herbal medicines on individuals. Contents of the invention [0004] The purpose of this application is to provide the preparation method of capsule. [0005] The purpose of the application is achieved through the following technical solutions: may comprise the following steps: [0006] The invention...

Claims

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Application Information

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IPC IPC(8): A61K9/48A61K36/344A61K36/258A61K36/704A61K36/539A61K36/23A61K36/634A61K36/28
CPCA61K9/4808A61K36/344A61K36/258A61K36/704A61K36/539A61K36/23A61K36/634A61K36/28A61K2236/19
Inventor 林金飞蔡祥高志良陈涛张静史圣楠王珊霞谢婕思
Owner 广东南芯医疗科技有限公司
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