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Probiotic composition for improving hyperglycemia

A technology of probiotics and composition, applied in the field of biomedicine, can solve the problems of limited replacement of drugs, patients can only rely on insulin, ketone poisoning, etc.

Inactive Publication Date: 2020-01-03
上海立龙生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Excessive accumulation of ketone bodies in the blood can cause ketone poisoning, and in severe cases, death can result if the rescue is not timely
[0007] At present, oral drugs are usually used first in the clinical treatment of diabetes, including metformin, acarbose, etc., to increase the body's sensitivity to insulin; Drugs combined with insulin injection can regain control of blood sugar, but the replacement drugs are limited, and patients often end up in a situation where they can only rely on insulin
For people with borderline hyperglycemia (incipient diabetes), there is currently no clinically feasible solution

Method used

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  • Probiotic composition for improving hyperglycemia
  • Probiotic composition for improving hyperglycemia
  • Probiotic composition for improving hyperglycemia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Example 1, prevention of hyperglycemia in mice induced by a high-sugar and high-fat diet:

[0026] Six-week-old male C57 / B6 mice were divided into two groups, 10 in each group, divided into control group and probiotic group, and were bred in Shanghai Experimental Animal Center. The mice were uniformly fed a high-fat diet with a fat content of 60%, drinking water added with 5% glucose and 5% fructose, and a total of 10% sugar, and fed continuously for 8 weeks.

[0027] Mix the probiotics according to the following proportions: 22 parts of Bifidobacterium breve, 22 parts of Bifidobacterium longum, 18 parts of Lactobacillus casei, 18 parts of Lactobacillus acidophilus, 8 parts of Lactobacillus plantarum, 7 parts of Lactobacillus rhamnosus, 5 copies of Bifidobacterium adolescent. Each serving of probiotic composition contains a total of 5 billion live bacteria, the auxiliary material is maltodextrin, and the weight is 0.2g, which is dissolved in 0.5ml of normal saline and ...

Embodiment 2

[0029] Embodiment 2, improving early-onset diabetes / critical hyperglycemia:

[0030] Five adult males and five females were selected for fasting blood glucose measurement in Shanghai Changzheng Hospital. The probiotic composition is then taken orally twice a day, and the proportion of probiotics is as follows in parts by weight:

[0031] 22 parts of Bifidobacterium breve, 22 parts of Bifidobacterium longum, 18 parts of Lactobacillus casei, 18 parts of Lactobacillus acidophilus, 8 parts of Lactobacillus plantarum, 7 parts of Lactobacillus rhamnosus, 5 parts of Bifidobacterium adolescent. Each serving of the probiotic composition contains a total of 15 billion viable bacteria, and the auxiliary material is maltodextrin, additionally added fructooligosaccharide, fruit powder and xylitol, and the weight is 1.5g. Dissolve in warm water and drink, twice a day.

[0032] Four weeks later, fasting blood glucose was measured again at Shanghai Changzheng Hospital. The result is as f...

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Abstract

The invention relates to a probiotic composition for improving hyperglycemia. The probiotic composition is composed of probiotics and food or medically acceptable excipients or additives, and is characterized by being prepared from the following probiotics in parts by weight: 20-25 parts of bifidobacterium breve, 20-25 parts of bifidobacterium longum, 15-20 parts of lactobacillus casei, 15-20 parts of lactobacillus acidophilus, 5-10 parts of lactobacillus plantarum, 5-10 parts of lactobacillus rhamnosus and 5 parts of bifidobacterium adolescentis. The probiotic composition has the effect of lowering blood sugar.

Description

technical field [0001] The invention relates to the field of biomedicine, and relates to a probiotic composition for improving hyperglycemia, which is composed of several designated probiotics as raw materials. Background technique [0002] The human body ingests carbohydrates during eating, which is digested into glucose by the digestive system and absorbed into the blood. At this time, the blood sugar rises, insulin begins to be secreted, and the glucose enters the liver or muscle to synthesize glycogen, and the blood sugar gradually decreases; When the threshold is reached, glucagon begins to be secreted, and glycogen is re-decomposed into glucose and enters the blood to provide energy. Therefore, the blood sugar of the human body is within a relatively stable fluctuation range. [0003] Hyperglycemia is a metabolic disease, which refers to blood sugar exceeding the normal value, the absolute amount of insulin secretion in the body is insufficient (type I diabetes), or t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/745A61K35/747A61P3/10A23L33/135
CPCA61K35/745A61K35/747A61P3/10A23L33/135A23V2002/00A23V2400/125A23V2400/513A23V2400/519A23V2400/175A23V2400/113A23V2400/169A23V2400/533A61K2300/00A23V2200/328
Inventor 李燕
Owner 上海立龙生物科技有限公司
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