Tiripa peptide analogue

A technology of ripatide and analogues, applied in the field of tiripatide analogues, can solve the problems of inability to achieve full-effect blood sugar control and weight loss, and achieve the effects of stable properties, weight loss, and weight loss
CN110642935AInactive Publication Date: 2020-01-03CHENGDU AODA BIOTECHNOLOGY CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
CHENGDU AODA BIOTECHNOLOGY CO LTD
Publication Date
2020-01-03
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to the field of pharmaceutical synthesis, and discloses a tiripa peptide analogue. The tiripa peptide analogue is used for preparing pharmaceutical compositions for treatment ofdiseases, use of the pharmaceutical compositions to preparation of drugs for treatment of one or more of the following diseases is disclosed, and the diseases include type II diabetes, impaired glucose tolerance, type I diabetes, obesity, hypertension, metabolic syndrome, dyslipidemia, cognitive impairment, atherosclerosis, myocardial infarction, coronary heart disease, cardiovascular disease, stroke, inflammatory bowel syndrome and / or dyspepsia or gastric ulcer, liver fibrosis diseases and pulmonary fibrosis diseases.
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Description

technical field

[0001] The present invention relates to a kind of analogue of tiriparatide and its use, the analogue is a kind of dual function of stimulating human glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor Incretin peptide mimetic compounds. Background technique

[0002] GIP is a 42 amino acid gastrointestinal regulatory peptide that plays a physiological role in glucose homeostasis by stimulating insulin secretion from pancreatic β cells in the presence of glucose and protecting pancreatic β cells. GLP-1 is a 37 amino acid peptide that stimulates insulin secretion, protects pancreatic beta cells, and inhibits glucagon secretion, gastric emptying and food intake, leading to weight loss. GIP and GLP-1 are known as incretins; incretin receptor signaling plays a key physiologically relevant role for glucose homeostasis. In normal physiology, GIP and GLP-1 are secreted from the gut after a meal, and these incretins enhance...

Claims

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