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Bioactive glass particles and preparation method thereof

A bioactive glass, bioactive technology, applied in glass manufacturing equipment, glass molding, manufacturing tools, etc., can solve the problems of high energy consumption, irregular shape, wide particle size distribution of bioactive glass, etc., to reduce energy consumption , Narrow size range, controllable particle size effect

Active Publication Date: 2020-01-10
CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, this industrial production method requires high-temperature melting and later crushing, which consumes a lot of energy; moreover, the obtained bioactive glass has a wide particle size distribution and irregular shape

Method used

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  • Bioactive glass particles and preparation method thereof
  • Bioactive glass particles and preparation method thereof
  • Bioactive glass particles and preparation method thereof

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preparation example Construction

[0047] The invention provides a method for preparing bioactive glass particles, which is characterized in that it comprises the following steps:

[0048] a) mixing ethyl orthosilicate, triethyl phosphate, calcium nitrate tetrahydrate, citric acid and water, standing and aging to obtain a precursor sol;

[0049] b) sending the precursor sol solution to a spray drying device through a feeding pump for spray drying to obtain xerogel particles;

[0050] The feed flow rate of the feed pump is 90-110mL / min;

[0051] The conditions of the spray drying are as follows: the frequency of the atomizer is 200-350 Hz, the frequency of the hot air blower is 200-250 Hz, and the air outlet temperature is 120-250 °C;

[0052] c) calcining the xerogel to obtain bioactive glass particles;

[0053] The calcination temperature is 850-900°C.

[0054] According to the present invention, ethyl orthosilicate, triethyl phosphate, calcium nitrate tetrahydrate, citric acid and water are mixed first, le...

Embodiment 1

[0091] 1.1 Product preparation

[0092] S1. Add 20 g of citric acid to 300 mL of deionized water, and stir until completely dissolved. After an interval (with stirring) of 30 minutes, add 125g of ethyl orthosilicate, 14.6g of triethyl phosphate and 85g of calcium nitrate tetrahydrate to the solution in turn, with stirring during the addition, and continue to stir for 3 hours after the addition is completed. 90rpm; then stand at room temperature overnight in the dark to obtain the precursor sol.

[0093] S2, using figure 1 The integrated treatment device shown is for feeding and spray drying; wherein, the rotation speed of the peristaltic pump is 20rpm, and the feeding flow rate is 100mL / min; in the spray drying device, the frequency of the centrifugal atomizer is 300Hz, and the frequency of the hot air blower is 200Hz , the air outlet temperature is 180°C, and dry gel particles are obtained;

[0094] S3. Under the condition of sufficient air circulation, first raise the tem...

Embodiment 2

[0100] S1. Add 20 g of citric acid to 300 mL of deionized water, and stir until completely dissolved. After an interval (with stirring) of 30 minutes, add 125g of ethyl orthosilicate, 14.6g of triethyl phosphate and 85g of calcium nitrate tetrahydrate to the solution in turn, with stirring during the addition, and continue to stir for 3 hours after the addition is completed. 80rpm; then stand at room temperature overnight in the dark to obtain a precursor sol.

[0101] S2, using figure 1 The integrated treatment device shown is for feeding and spray drying; wherein, the rotation speed of the peristaltic pump is 15rpm, and the feeding flow rate is 100mL / min; in the spray drying device, the frequency of the centrifugal atomizer is 200Hz, and the frequency of the hot air blower is 200Hz , the air outlet temperature is 120°C, and dry gel particles are obtained;

[0102] S3. Under the condition of sufficient air circulation, first raise the temperature to 500°C at 3°C / min, then r...

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Abstract

The invention provides a bioactive glass particle and a preparation method thereof. The preparation method of the bioactive glass particles comprises the following steps: a) mixing tetraethyl orthosilicate, triethyl phosphate, calcium nitrate tetrahydrate, citric acid and water, and standing for aging to obtain a precursor sol solution; b) conveying the precursor sol solution into a spray drying device through a material conveying pump, and carrying out spray drying to obtain a dry gel, wherein the material conveying flow rate of the material conveying pump is 90-110 mL / min; rand the spray drying conditions are as follows: the frequency of an atomizer is 200-350 Hz, the frequency of an air heater is 200-250 Hz, and the air outlet temperature is 120-250 DEG C; and c) calcining the dry gel at a temperature of 850-900 DEG C to obtain the bioactive glass particle. The bioactive glass particle prepared in the invention has a high uniformity and a high apparent sphericity, and is of a hollowspherical structure, and the preparation method can reduce energy consumption.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a bioactive glass particle and a preparation method thereof. Background technique [0002] Bioactive glass is a special glass material with tissue repair function, mainly composed of SiO 2 , CaO, P 2 o 5 Such composition, originally developed by Professor Hench of the University of Florida in the 1870s, belongs to the silicate system and has a specific chemical composition. Bioactive glass was first used in the related research of bone tissue repair, because it can produce bonding effect after implanted in the body to tightly bond bone tissue without causing adverse reactions such as inflammation, and has good biocompatibility and bioactivity , which has aroused great concern in the field of biomedical materials. With the development of material preparation technology, the preparation process, chemical composition, structure and physical and chemical properties o...

Claims

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Application Information

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IPC IPC(8): C03C4/00C03C6/00C03B19/06
CPCC03B19/06C03C1/00C03C4/0007
Inventor 章培标武振旭郭敏王宇王宗良史新翠焦自学
Owner CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI