Specially-acetylcholine-receptor-targeted D8 polypeptide with biomembrane-crossing effect and brain-targeted drug delivery system thereof

A technology of acetylcholine receptor and drug delivery system, which is applied in the field of pharmacy, can solve the problems of affecting targeting efficiency, hydrolysis, low immunogen and the like, and achieve the effects of good targeting effect and good immunocompatibility.
CN110669101AActive Publication Date: 2020-01-10FUDAN UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
FUDAN UNIV
Publication Date
2020-01-10

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Abstract

The invention, which belongs to the field of pharmacy, relates to a D8 polypeptide and a brain-targeted drug delivery system thereof, particularly to, a specially-acetylcholine-receptor-targeted D8 polypeptide with a biomembrane-crossing effect and a brain-targeted drug delivery system thereof. According to the invention, a nano-carrier modified by the polypeptide molecule D8 is specifically combined or taken by a positive cell expressing an acetylcholine receptor to realize strong brain targeting and imaging functions and the capability of affinity with a biomembrane barrier to form a cell. With a constructed nano drug delivery system, such as lipidosome, polymer micelle, a polymer disc, and a nanoparticle, an entrapped model drug can be delivered to a brain tissue and a cell expressing an acetylcholine receptor effectively, so that the treatment effect to diseases in brain can be improved obviously; the side effect is low; and the immunocompatibility is high. Therefore, the D8 polypeptide and the brain-targeted drug delivery system thereof have the broad application prospects in fields of diagnosis and targeted therapy of intracerebral diseases such as intracerebral tumors.
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Description

technical field

[0001] The invention belongs to the field of pharmacy, relates to D8 polypeptide and its brain-targeted drug delivery system, in particular to a targeted polypeptide molecule that can cross biomembrane barriers, especially the blood-brain barrier (BBB), and specifically targets acetylcholine receptors and The D8 polypeptide with transbiofilm effect and its brain-targeted drug delivery system, and its modified complexes and nano drug delivery systems are used in the preparation of preparations for the diagnosis and treatment of peripheral tumors, brain tumors and other brain diseases. The present invention The peptides are more stable in serum, have better targeting effect, and have better immunocompatibility. Background technique

[0002] Due to the existence of the blood-brain barrier, it is difficult for traditional drugs to enter the brain, causing a major problem in the clinical treatment of brain diseases. Therefore, active targeted drug delivery systems...

Claims

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