Multi-crosslinking hydrogel for meniscus repair and preparation method of hydrogel

Abstract

The invention relates to a multi-crosslinking hydrogel for meniscus repair and a preparation method of the hydrogel. The hydrogel is prepared from a first solution and a second solution, a first component contained in the first solution is a modified collagen substance with a side chain containing a sulfydryl group and an amino group, and a second component contained in the second solution is modified polysaccharide with a side chain containing an aldehyde group and succinimide. The preparation method includes blending the first solution and the second solution. The multi-crosslinking meniscusrepair hydrogel can be applied to meniscus sutures to form a protective barrier, and can protect the meniscus sutures from physical wearing of articular cartilages in a recovery period; the gel is endowed with a self-repairing function through dynamic crosslinking, tiny defects of the gel can be automatically repaired, healing of sutured wounds can be promoted, tiny gaps in sutured positions arefilled, and therefore meniscus repairing is promoted, the postoperative recovery time is shortened, and the effect after healing is improved; in addition, the gel can also be used for filling mild articular surface defects, and cartilage defects are repaired in cooperation with a micro-fracture operation.

Description

technical field [0001] The invention relates to a multi-crosslinked meniscus repair hydrogel and a preparation method thereof, belonging to the technical field of medical materials. Background technique [0002] As far as the applicant knows, meniscus injury is one of the most common knee joint injuries, because the knee joint lacks blood supply, and most nutrients can only be provided through the circulation of synovial fluid. Once the meniscus is damaged, it is difficult to repair itself. The meniscus is divided into a red area and a white area. The red area is the peripheral blood supply area, and the injury in this area is easier to heal; once the injury occurs in the white area, that is, the ischemic supply area, self-healing will basically not occur. [0003] Common clinical meniscus repair techniques include arthroscopic-based inside-outside technique, outside-inside technique, all-inside technique, T-Fix technique, and meniscus arrow. Among them, the T-Fix suture t...

AI Technical Summary

Problems solved by technology

But, on the one hand, this technical scheme needs to rely on star macromolecule or comb-like macromolecule as starting material, and this just is completely different from the present invention; On the other hand, although component a and component b in this technical scheme can Each has different active groups and these active groups have a large selection range. However, which specific active groups should be carried by the two components and what proportion / quantity of specific active groups should be carried respectively. These factors are often would result in fundamentally different physical / chemical properties of the resulting material, which would lead to very different uses, which is not addressed in the technical proposal

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