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Ciprofloxacin glucose injection and preparation process thereof

A technology of glucose injection and ciprofloxacin, which is applied in the directions of non-active ingredients medical preparations, medical preparations containing active ingredients, organic active ingredients, etc., can solve the problems of the absence of ciprofloxacin and glucose, etc., To achieve the effect of improving the treatment of typhoid fever, less related substances, and strong pH buffering capacity

Inactive Publication Date: 2020-01-17
湖北津药药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, there is no record of cooperating ciprofloxacin and glucose in the injection solution in the prior art

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] The invention provides a ciprofloxacin glucose injection, the raw materials of which have the following formula by weight: 1 part of ciprofloxacin, 40 parts of glucose, 1 part of glutamic acid and 800 parts of water for injection.

[0023] The present invention also provides a preparation process of ciprofloxacin glucose injection, comprising the steps of:

[0024] S1. Select the first concentrated preparation tank, and add a prepared amount of 20% water for injection to the first concentrated prepared tank, start stirring, add the prepared amount of glutamic acid to dissolve, add the prepared amount of ciprofloxacin, and heat to 90 Above ℃, stir to dissolve, after complete dissolution, keep warm for 30 minutes, lower the temperature of the liquid medicine to below 40℃, measure the pH, keep the pH between 4.4-4.8, then add 50% lactic acid to adjust the pH value to 3.8- 4.3, and the addition of 50% lactic acid is 5 / 10,000, add activated carbon according to 0.2% of the co...

Embodiment 2

[0032] The invention provides a ciprofloxacin glucose injection, the raw materials of which are formulated by weight as follows: 2 parts of ciprofloxacin, 50 parts of glucose, 1.2 parts of glutamic acid and 1000 parts of water for injection.

[0033] The present invention also provides a preparation process of ciprofloxacin glucose injection, comprising the steps of:

[0034] S1. Select the first concentrated preparation tank, and add a prepared amount of 20% water for injection to the first concentrated prepared tank, start stirring, add the prepared amount of glutamic acid to dissolve, add the prepared amount of ciprofloxacin, and heat to 90 Above ℃, stir to dissolve, after complete dissolution, keep warm for 30 minutes, lower the temperature of the liquid medicine to below 40℃, measure the pH, keep the pH between 4.4-4.8, then add 50% lactic acid to adjust the pH value to 3.8- 4.3, and the addition of 50% lactic acid is 5 / 10,000, add activated carbon according to 0.2% of th...

Embodiment 3

[0042] The invention provides a ciprofloxacin glucose injection, the raw materials of which are formulated by weight as follows: 3 parts of ciprofloxacin, 60 parts of glucose, 1.5 parts of glutamic acid and 1200 parts of water for injection.

[0043] The present invention also provides a preparation process of ciprofloxacin glucose injection, comprising the steps of:

[0044] S1. Select the first concentrated preparation tank, and add a prepared amount of 20% water for injection to the first concentrated prepared tank, start stirring, add the prepared amount of glutamic acid to dissolve, add the prepared amount of ciprofloxacin, and heat to 90 Above ℃, stir to dissolve, after complete dissolution, keep warm for 30 minutes, lower the temperature of the liquid medicine to below 40℃, measure the pH, keep the pH between 4.4-4.8, then add 50% lactic acid to adjust the pH value to 3.8- 4.3, and the addition of 50% lactic acid is 5 / 10,000, add activated carbon according to 0.2% of th...

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PUM

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Abstract

The invention discloses a ciprofloxacin glucose injection and a preparation method thereof. The ciprofloxacin injection comprises the following raw materials in parts by weight: 1-3 parts of ciprofloxacin, 40-60 parts of glucose, 1-1.5 parts of glutamic acid and 800-1200 parts of water for injection. The invention also provides a preparation process of the ciprofloxacin glucose injection. According to the invention, ciprofloxacin and glucose are combined with each other, and the proportion of the ciprofloxacin and the glucose is reasonably controlled so as to remarkably improve the effects ofciprofloxacin on treating typhoid fever, bone and joint infection and skin soft tissue infection. When the injection is prepared, lactic acid and activated carbon are used for adjusting the pH value,and has high pH value buffering capacity. The ciprofloxacin glucose injection prepared by the method generates few related substances and has good quality.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a ciprofloxacin glucose injection and a preparation process thereof. Background technique [0002] Ciprofloxacin glucose injection is indicated for 1. Genitourinary system infection caused by sensitive bacteria, including simple and complicated urinary tract infection, bacterial prostatitis, Neisseria gonorrhoeae urethritis or cervicitis (including caused by enzyme-producing strains). 2. Respiratory tract infection, including acute attack of bronchial infection and lung infection caused by sensitive gram-negative bacilli. 3. Gastrointestinal infection, caused by Shigella, Salmonella, enterotoxigenic Escherichia coli, Aeromonas hydrophila, Vibrio parahaemolyticus, etc. 4. Typhoid fever. 5. Bone and joint infection. 6. Skin and soft tissue infection. 7. Septicemia and other systemic infections. [0003] At present, there is no record of cooperating ciprofl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K47/12A61K47/04A61K31/496A61K31/7004A61P31/04A61P19/08A61P19/02A61P17/00
CPCA61K9/0019A61K9/08A61K31/496A61K31/7004A61K47/02A61K47/12A61P17/00A61P19/02A61P19/08A61P31/04A61K2300/00Y02A50/30
Inventor 曹琦
Owner 湖北津药药业股份有限公司
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