A kind of preparation method of moxifloxacin synthesis catalyst

Abstract

The invention discloses a method for preparing a catalyst for moxifloxacin synthesis. The catalyst includes activated carbon, an oxide of an auxiliary element loaded on the activated carbon, and an active component Pd loaded on the activated carbon; the auxiliary element It is Si, Al or Zr; the preparation method of the catalyst includes: 1. preparation of activated carbon carrier; 2. oxide modified activated carbon carrier; The present invention changes the acidity and alkalinity of the surface of the catalyst by preferentially adsorbing the oxide of the auxiliary element on the activated carbon, thereby enhancing the ability of the catalyst to resist nitrogen poisoning, and at the same time, the active component palladium and the oxide of the auxiliary element have a strong binding ability, The performance degradation of the catalyst caused by the loss of active component metal is avoided, and the use of ethylene glycol aqueous solution as the impregnation solvent makes it easier to control the distribution depth of the active component on the carrier, forming a protein-type distribution with anti-toxicity, and improving the stability of the catalyst.

Description

technical field [0001] The invention belongs to the technical field of preparation of noble metal catalysts, in particular to a method for preparing a moxifloxacin synthesis catalyst. Background technique [0002] Moxifloxacin, the chemical name is 1-cyclopropyl-7-[(S,S)-2,8-diazabicyclo[4.3.0]-nonan-8-yl]-6-fluoro-8- Methoxy-1,4-dihydro-4-oxo-3-quinoline carboxylic acid is a fourth-generation broad-spectrum fluoroquinolone antibacterial drug developed by Bayer AG of Germany and launched in Germany in 1999. It is clinically used For the treatment of chronic obstructive pulmonary disease, acute bacterial sinusitis, and skin and soft tissue infections, the drug has strong antibacterial activity, broad antibacterial spectrum, and is not prone to drug resistance. In 2002, it entered the top ten best-selling antibiotic drugs in the world. In the second half of 2002, moxifloxacin was listed in my country. In 2004, the drug entered the national medical insurance catalog, and the m...

AI Technical Summary

Problems solved by technology

Palladium carbon catalyst is a kind of excellent hydrogenation and hydrogenolysis catalyst, is widely used in drug synthesis process, and it has advantages such as small consumption and environmental protection, but its price is expensive, restricts the production cost of moxifloxacin drug to a large extent, therefore Good catalyst activity, selectivity and mechanical performance are the key to the production cost of moxifloxacin

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