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A kind of preparation method of palladium carbon catalyst for imipenem

A technology of palladium-carbon catalyst and imipenem, which is applied in chemical instruments and methods, physical/chemical process catalysts, metal/metal oxide/metal hydroxide catalysts, etc., can solve the problem of few preparation methods of precious metal palladium-carbon catalysts, etc. problems, to achieve the effect of improving equilibrium adsorption performance, improving utilization rate, and improving activity

Active Publication Date: 2021-08-17
XIAN CATALYST NEW MATERIALS CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, most of the patent literature reports on imipenem involve its synthesis process, which is related to the preparation methods of the precious metal palladium carbon catalyst used.

Method used

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  • A kind of preparation method of palladium carbon catalyst for imipenem

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Effect test

Embodiment 1

[0027] 1. Reflux 20g of activated carbon with 0.5% glycine aqueous solution at 100°C for 1 hour, then wash the treated activated carbon with pure water until it is neutral, and dry it.

[0028] 2. Take 18g of activated carbon dried in step 1 and place it in an aqueous sodium acetate solution with a mass concentration of 0.5%, soak it for 4 hours at a temperature of 50°C, and filter to obtain a filter cake, which is beaten with pure water to obtain Activated carbon slurry.

[0029] 3. After dissolving palladium chloride containing 2g of palladium with hydrochloric acid with a mass concentration of 5%, sodium nitrite was added to obtain a modified active component solution, wherein the mass concentration of sodium nitrite was 1%.

[0030] 4. At a temperature of 20°C, add the modified active component solution obtained in step 3 dropwise to the activated carbon slurry in step 2, soak for 3 hours after the addition is completed, and then use NaOH with a mass concentration of 5% A...

Embodiment 2

[0033] 1. Reflux 20g of activated carbon with a glycine aqueous solution with a mass concentration of 1.0% at 90°C for 2 hours, then wash the treated activated carbon with pure water until it is neutral, and dry it.

[0034] 2. Take 18g of activated carbon dried in step 1 and place it in an aqueous sodium acetate solution with a mass concentration of 2.5%, soak it for 6 hours at a temperature of 20°C, and filter to obtain a filter cake, which is beaten with pure water to obtain Activated carbon slurry.

[0035] 3. After dissolving palladium chloride containing 2g of palladium in hydrochloric acid with a mass concentration of 10%, sodium nitrite was added to obtain a modified active component solution, wherein the mass concentration of sodium nitrite was 3%.

[0036] 4. At a temperature of 30°C, add the modified active component solution obtained in step 3 dropwise to the activated carbon slurry in step 2, soak for 5 hours after the addition is completed, and then use NaOH with...

Embodiment 3

[0039] 1. Reflux 20g of activated carbon with a glycine aqueous solution with a mass concentration of 1.5% at 95°C for 3 hours, then wash the treated activated carbon with pure water until it is neutral, and dry it.

[0040] 2. Take 18g of activated carbon dried in step 1 and place it in an aqueous potassium acetate solution with a mass concentration of 1.5%, soak it for 8 hours at a temperature of 30°C, and filter to obtain a filter cake, which is beaten with pure water to obtain Activated carbon slurry.

[0041] 3. After dissolving palladium chloride containing 2g of palladium with hydrochloric acid with a mass concentration of 7.5%, sodium nitrite was added to obtain a modified active component solution, wherein the mass concentration of sodium nitrite was 5%.

[0042] 4. At a temperature of 40°C, add the modified active component solution obtained in step 3 dropwise to the activated carbon slurry in step 2, soak for 8 hours after the addition is completed, and then use KOH...

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Abstract

The invention provides a preparation method of a palladium-carbon catalyst for imipenem. In the method, activated carbon is refluxed with a low-concentration glycine aqueous solution, and then impregnated with a water-soluble acetate aqueous solution; Add sodium nitrate dropwise to the treated activated carbon slurry for impregnation, adjust the pH of the system to 8-9 with lye after impregnation, filter, and beat the obtained filter cake with pure water, then add sodium borohydride for reduction to obtain palladium carbon catalyst. The present invention uses a low-concentration glycine aqueous solution to treat the activated carbon, and impregnates the activated carbon with a water-soluble acetate aqueous solution, which can not only modify its surface chemical structure, but also avoid the pollution caused by the traditional nitric acid treatment of activated carbon; at the same time, by adjusting the modified active component solution, The palladium ion in the chelated state is prepared, so as to achieve the purpose of controlling the activity and selectivity of the catalyst. The method has a simple process and is beneficial to industrial scale-up production.

Description

technical field [0001] The invention belongs to the technical field of catalyst preparation, and in particular relates to a preparation method of a palladium carbon catalyst for imipenem. Background technique [0002] Imipenem is an N-iminomethyl derivative of the natural antibiotic thiamphenicol. Because of its superior pharmacological activity and high chemical stability, it has become the first carbapenem antibiotic used clinically in the world. Imipenem inhibits the synthesis of bacterial cell walls by specifically binding to a variety of penicillin-binding proteins, causing the bacteria to die due to cell lysis, thereby achieving the purpose of antibacterial. Because imipenem is easily metabolized and inactivated by renal dehydropeptidase-I of human kidney epithelial cells, it is often used in combination with cilastatin sodium (trade name "Taineng") at a ratio of 1:1 to Block the metabolism of imipenem in the kidney, reduce its nephrotoxicity and enhance the curative...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01J23/44C07D477/20C07D477/06
CPCB01J23/44C07D477/06C07D477/20
Inventor 闫江梅李岳锋王昭文张鹏张磊李小虎曾永康张之翔
Owner XIAN CATALYST NEW MATERIALS CO LTD
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