Synthesis method and application low-temperature-melting drug sustained-release medical polymer material

A technology of polymer materials and synthesis methods, which is applied in the field of synthesis of low-temperature melting drug slow-release medical polymer materials, can solve problems such as difficult healing of various therapeutic factors, and achieve the effect of wide application range and simple and effective preparation and operation process

Inactive Publication Date: 2020-01-17
XI AN JIAOTONG UNIV
View PDF10 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] Therefore, it is difficult to achieve the synergistic and controllable healing treatment of multiple therapeutic factors, and the continuous and effective dru

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Synthesis method and application low-temperature-melting drug sustained-release medical polymer material
  • Synthesis method and application low-temperature-melting drug sustained-release medical polymer material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] 5% by weight of glycerin (glycerol) relative to ε-caprolactone was mixed therewith. Then add the catalyst stannous isooctanoate relative to ε-caprolactone 1wt%, stir and mix thoroughly. Place in a vacuum drying oven to evacuate (vacuum degree-80kPa) and heat to 120°C for 24 hours. Stop heating under vacuum, and quickly cool down to room temperature after taking it out. The product was washed in glacial ether. After cooling at room temperature, the upper layer of ether was poured out completely. Place in a vacuum drying oven at 60°C and heat to liquid state. After precipitation in ice methanol, the supernatant was decanted. Vacuum filtration at 100°C for 72 hours. The final product was obtained after cooling at room temperature under vacuum.

Embodiment 2

[0043] 20% by weight of glycerin (glycerol) relative to ε-caprolactone was mixed therewith. Then add 2wt% catalyst stannous isooctanoate relative to ε-caprolactone, stir and mix well. Place in a vacuum drying oven to evacuate (vacuum degree-80kPa) and heat to 120°C for 24 hours. Stop heating under vacuum, and quickly cool down to room temperature after taking it out. The product was washed in glacial ether. After cooling at room temperature, the upper layer of ether was poured out completely. Place in a vacuum oven and heat at 60°C for 24 hours. The final product was obtained after cooling at room temperature under vacuum.

Embodiment 3

[0045] Pour the material prepared in Example 1 into a tablet coating machine and keep the temperature at 60°C. The tablet to be coated is coated, and the tablet coated with the material is obtained after cooling.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
Viscosityaaaaaaaaaa
Login to view more

Abstract

The invention discloses a synthesis method and application of a low-temperature-melting drug sustained-release medical polymer material. The material is modified on the basis of a polycaprolactone polymer with good biocompatibility, and remains in a molten state for a sufficient time after being heated to body temperature. In addition, the material is biodegradable in vivo and degradation productsare harmless. The material can be used for wound filling under body temperature, medicine carrying and slow release, low-temperature medical coating, and the like, is simple and feasible to operate and remarkable in effect, and has wide medical application prospects.

Description

technical field [0001] The invention relates to the technical field of polymer synthesis, in particular to a synthesis method and application of a low-temperature melting medicine slow-release medical polymer material. Background technique [0002] Tang Yonghong (CN101352582A) etc. mixed polycaprolactone (PCL) and polylactic acid (PLA) in a co-solvent (such as methylene chloride, tetrahydrofuran, chloroform, etc.). The material was prepared into a nanofiber mat using electrospinning technology, and then soaked in a hyaluronic acid (HA) solution after plasma modification. A porous PCL-PLA-HA composite tissue engineering scaffold was obtained. This method can only prepare solid stents first, but fails to carry out drug loading and injection implantation. [0003] Alona Shagan et al. (Adv. Funct. Mater. 2019, 1900998) achieved ~50°C extrudable tissue dressings by functionalizing PCL. N-hydroxysuccinimide is further introduced to make the material have a certain bonding effec...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): C08G63/08A61K47/34A61L31/10
CPCA61K47/34A61L31/10C08G63/08
Inventor 杨航贾坤孔宁
Owner XI AN JIAOTONG UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap