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Iodine glycerin nipple infusion and preparation method thereof

A technology of iodine glycerin and nipples, which is applied in the direction of pharmaceutical formulations, local antibacterial agents, active ingredients of iodine compounds, etc., can solve the problems of weakened bactericidal effect of nipples, difficulty in ensuring drug adhesion, weak liquid adsorption capacity, etc., to ensure wettability , Shorten the dissolution time, the effect of long drug effect

Inactive Publication Date: 2020-01-21
河北远征药业有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, no matter the prescriptions in the Pharmacopoeia or the patent have weak liquid adsorption ability, it is difficult to form adsorption to the skin, and the wall-hanging ability is weak
Whether using a medicated bath cup to infiltrate each nipple individually or spraying and sterilizing the nipples with a hand-held sprayer and a soft hose connected to a disinfection tank internal pressure pump, it is difficult to ensure that the drug adheres to the skin of the nipple. Droplets drip, resulting in waste of liquid medicine and weakened bactericidal effect on teats

Method used

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  • Iodine glycerin nipple infusion and preparation method thereof
  • Iodine glycerin nipple infusion and preparation method thereof
  • Iodine glycerin nipple infusion and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Preparation of 2% iodine glycerin recipe:

[0021]

[0022] Preparation:

[0023] Accurately weigh iodine and potassium iodide according to the prescription quantity, first dissolve potassium iodide in 200ml water, add iodine while stirring after being completely dissolved, accurately weigh polyvinylpyrrolidone and add it to the above solution, stir until completely dissolved, this is solution A.

[0024] Accurately weigh gum arabic and polyvinyl alcohol 1788 into about 400ml of water, heat up to 60°C, stir until completely dissolved, cool down to room temperature, this is solution B.

[0025] Mix solution A and solution B under stirring condition, and stir until homogeneous.

[0026] Add the prescribed amount of glycerin to the above homogeneously mixed solution, stir until uniform; then dilute to 1000ml with purified water.

Embodiment 2

[0028] Preparation of 2% iodine glycerin recipe:

[0029]

[0030] Preparation:

[0031] Accurately weigh iodine and potassium iodide according to the prescription quantity, first dissolve potassium iodide in 200ml water, add iodine while stirring after being completely dissolved, accurately weigh polyvinylpyrrolidone and add it to the above solution, stir until completely dissolved, this is solution A.

[0032] Accurately weigh gum arabic and polyvinyl alcohol 1788 into about 400ml of water, heat up to 60°C, stir until completely dissolved, cool down to room temperature, this is solution B.

[0033] Mix solution A and solution B under stirring condition, and stir until homogeneous.

[0034] Add the prescribed amount of glycerin to the above homogeneously mixed solution, stir until uniform; then dilute to 1000ml with purified water.

Embodiment 3

[0036] Preparation of 1% iodine glycerin recipe:

[0037]

[0038]

[0039] Preparation:

[0040] Accurately weigh iodine and potassium iodide according to the prescription quantity, first dissolve potassium iodide in 200ml water, add iodine while stirring after being completely dissolved, accurately weigh polyvinylpyrrolidone and add it to the above solution, stir until completely dissolved, this is solution A.

[0041] Accurately weigh gum arabic and polyvinyl alcohol 1788 into about 400ml of water, heat up to 60°C, stir until completely dissolved, cool down to room temperature, this is solution B.

[0042] Mix solution A and solution B under stirring condition, and stir until homogeneous.

[0043] Add the prescribed amount of glycerin to the above homogeneously mixed solution, stir until uniform; then dilute to 1000ml with purified water.

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PUM

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Abstract

The invention belongs to the field of veterinary drug preparations, and particularly relates to an iodine glycerin nipple infusion special for dairy cattle nipples and a preparation method thereof. The iodine glycerin nipple infusion is prepared from iodine, potassium iodide, polyvinylpyrrolidone, Arabic gum, polyvinyl alcohol, glycerinum and purified water. According to the novel iodine glycerinnipple infusion and the preparation method thereof, the adsorbability of liquid medicine to skin is increased, in using of the soups, the phenomenon of liquid medicine dropping cannot occur, the liquid medicine can be well absorbed on the surface of the skin to form a layer of protective films, the using efficiency of the liquid medicine is greatly improved, and the bactericidal effect of medicated bath solutions is better met. At present, iodine glycerin nipple infusion is not reported by other patents and documents.

Description

technical field [0001] The invention belongs to the field of veterinary drug preparations, and in particular relates to an iodine glycerin teat infusion specially used for cow teats and a preparation method thereof. Background technique [0002] Nipple dipping is of great significance in preventing the occurrence of dairy cow mastitis. For the method of medicated bath, you can use a medicated bath cup to infiltrate each nipple individually, or you can use a hand-held sprayer or a soft hose connected to the internal pressure pump of the disinfection pool to spray and sterilize the nipples. Commonly used nipple dipping solutions in China include povidone-iodine, chlorhexidine, sodium hypochlorite, and bromogeramine, which have the advantages of strong bactericidal ability and low irritation, but the above dipping solutions are mostly water-soluble solutions, and the volatilization speed is fast in summer. Short, especially in winter, prone to frostbite and chapped nipple skin...

Claims

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Application Information

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IPC IPC(8): A61K33/18A61K47/32A61K9/08A61K47/10A61P31/02A61P31/04
CPCA61K9/0014A61K9/08A61K33/18A61K47/10A61K47/32A61P31/02A61P31/04A61K2300/00
Inventor 黄凯郭鸿志李红园吕让任丽花孔瑞岗李冀张玉郭建立田俊岭
Owner 河北远征药业有限公司
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