Natural silk-reinforced hydroxyapatite/chitosan composite film and preparation method thereof
A technology of hydroxyapatite and nano-hydroxyapatite, which is applied in medical formula, medical science, surgery, etc., can solve the problems of low mechanical properties and fast degradation, and achieve simple preparation methods, accelerated bone growth, and improved mechanical properties. performance effect
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Example Embodiment
[0013] Example 1: Dissolve 1.0 g of chitosan in 50 ml of 2% glacial acetic acid to obtain a light yellow transparent mucus. Add 0.2 g of nano-hydroxyapatite powder (average particle size of 25 nm) to 10 ml of deionized water for ultrasound After dispersing for 20 minutes, add it dropwise to the chitosan solution under high-speed stirring. After stirring for 4 hours at room temperature, let it stand for defoaming. Take half of the composite solution and cast it on a smooth and dry glass plate to form a film. Spread out 1.0 g of undegummed silk, and then cast the remaining half of the compound solution on the silk. After natural drying, a smooth dense film is obtained. The tensile strength of the composite membrane is 33 MPa, and the elongation at break is 20%; the membrane is immersed in simulated body fluid for 24 hours, and its surface has been completely covered by bone-like apatite by SEM observation; the immersion lasts for 8 weeks, and the membrane is stretched. The tensil...
Example Embodiment
[0014] Example 2: Dissolve 1.0 g of chitosan in 50 ml of 2% glacial acetic acid to obtain a light yellow transparent mucus. Add 0.1 g of nano-hydroxyapatite powder (average particle size of 25 nm) to 20 ml of deionized water for ultrasound After dispersing for 25 minutes, add dropwise to the chitosan solution under high-speed stirring, continue stirring at room temperature for 4 hours, let stand to defoam, take half of the composite solution and cast on a smooth and dry glass plate to form a film, and then on top Straighten 1.5 g of undegummed silk, and then cast the remaining half of the above-mentioned composite liquid on the silk. After natural drying, a smooth dense film is obtained. The tensile strength of the composite film is 36 MPa, and the elongation at break is 27%; the film is immersed in simulated body fluid for 24 hours, and most of its surface is covered by bone-like apatite after SEM observation; the immersion lasts for 8 weeks, and the film is stretched The tens...
Example Embodiment
[0015] Example 3: Dissolve 1.0 g of chitosan in 50 ml of 2% glacial acetic acid to obtain a light yellow transparent mucus. Add 0.2 g of nano-hydroxyapatite powder (average particle size of 25 nm) to 10 ml of deionized water for ultrasound After dispersing for 25 minutes, add dropwise to the chitosan solution under high-speed stirring, continue stirring at room temperature for 4 hours, let stand to defoam, take half of the composite solution and cast on a smooth and dry glass plate to form a film, and then on top Spread out 0.5 g of undegummed silk, and then cast the remaining half of the compound solution on the silk. After natural drying, a smooth dense film is obtained. The tensile strength of the composite membrane is 29 MPa, and the elongation at break is 24%; the membrane is immersed in simulated body fluid for 24 hours, and its surface has been completely covered by bone-like apatite by SEM observation; the immersion lasts for 8 weeks, and the membrane is stretched The t...
PUM
| Property | Measurement | Unit |
|---|---|---|
| Tensile strength | aaaaa | aaaaa |
| Tensile strength | aaaaa | aaaaa |
| Tensile strength | aaaaa | aaaaa |
Abstract
Description
Claims
Application Information
Login to view more - R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap