Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Natural silk-reinforced hydroxyapatite/chitosan composite film and preparation method thereof

A technology of hydroxyapatite and nano-hydroxyapatite, which is applied in medical formula, medical science, surgery, etc., can solve the problems of low mechanical properties and fast degradation, and achieve simple preparation methods, accelerated bone growth, and improved mechanical properties. performance effect

Active Publication Date: 2020-01-24
HUNAN NORMAL UNIVERSITY
View PDF4 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Based on the above technology, in view of the low mechanical properties and fast degradation of chitosan, if the natural silk fabric is directly used as the skeleton to strengthen the chitosan film in situ, it is expected to obtain a natural silk-enhanced nano-hydroxyapatite / Chitosan composite film, that is, a composite film with superior mechanical properties, degradation performance, better biocompatibility, and endowed with certain antibacterial properties is used as a guided bone tissue regeneration film

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Natural silk-reinforced hydroxyapatite/chitosan composite film and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Example 1: Dissolve 1.0 g of chitosan in 50 ml of 2% glacial acetic acid to obtain light yellow transparent mucus, add 0.2 g of nano-hydroxyapatite powder (average particle size is 25 nm) and add 10 ml of deionized water for ultrasonic After dispersing for 20 minutes, add dropwise to the chitosan solution under high-speed stirring, continue to stir at room temperature for 4 hours, let it stand for defoaming, take half of the above compound solution and cast it on a smooth and dry glass plate to form a film, and then spread it on it Straighten and spread 1.0 g of undegummed silk, then cast the remaining half of the above compound solution on the silk, and dry it naturally to obtain a smooth and dense film. The tensile strength of the composite film was 33 MPa, and the elongation at break was 20%. The film was soaked in simulated body fluid for 24 hours, and the surface of the film was completely covered by bone-like apatite as observed by SEM; the film stretched until 8 w...

Embodiment 2

[0014] Example 2: Dissolve 1.0 g of chitosan in 50 ml of 2% glacial acetic acid to obtain light yellow transparent mucus, add 0.1 g of nano-hydroxyapatite powder (average particle size is 25 nm) and add 20 ml of deionized water for ultrasonic After dispersing for 25 minutes, add dropwise to the chitosan solution under high-speed stirring, continue to stir at room temperature for 4 hours, let it stand for defoaming, take half of the above compound solution and cast it on a smooth and dry glass plate to form a film, and then spread it on it Straighten and spread 1.5 g of undegummed silk, then cast the remaining half of the above compound solution on the silk, and dry it naturally to obtain a smooth and dense film. The tensile strength of the composite film was 36 MPa, and the elongation at break was 27%. The film was soaked in simulated body fluid for 24 hours, and most of its surface was covered by bone-like apatite as observed by SEM; the film stretched until 8 weeks. The tens...

Embodiment 3

[0015] Example 3: Dissolve 1.0 g of chitosan in 50 ml of 2% glacial acetic acid to obtain light yellow transparent mucus, add 0.2 g of nano-hydroxyapatite powder (average particle size is 25 nm) and add 10 ml of deionized water for ultrasonic After dispersing for 25 minutes, add dropwise to the chitosan solution under high-speed stirring, continue to stir at room temperature for 4 hours, let it stand for defoaming, take half of the above compound solution and cast it on a smooth and dry glass plate to form a film, and then spread it on it Straighten and spread 0.5 g of undegummed silk, then cast the remaining half of the above compound solution on the silk, and dry naturally to obtain a smooth and dense film. The tensile strength of the composite film was 29 MPa, and the elongation at break was 24%. The film was soaked in simulated body fluid for 24 hours, and its surface was completely covered by bone-like apatite as observed by SEM; the film stretched until 8 weeks. The tens...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Tensile strengthaaaaaaaaaa
Tensile strengthaaaaaaaaaa
Tensile strengthaaaaaaaaaa
Login to View More

Abstract

The invention discloses a natural silk-reinforced hydroxyapatite / chitosan composite film and a preparation method thereof. The composite film is obtained by a method of combining solution-casting andfiber in-situ reinforcement. The preparation method of the composite film comprises the following steps: firstly preparing a uniform composite liquid from nano-hydroxyapatite and chitosan; then casting a half of the nano-hydroxyapatite / chitosan composite solution into a film; thirdly laying natural silk on the film; and finally casting the remaining half of the nano-hydroxyapatite / chitosan composite solution on the silk and naturally drying to obtain the composite film. The novel composite film has rich sources of the raw materials, and the preparation method is simple. In addition, mechanicalproperties, degradation performance, osteoconductivity and antibacterial properties of the composite film can be regulated and controlled by component contents of the composite film, and the composite film with excellent performance is expected to be obtained for guiding bone tissue regeneration membranes.

Description

technical field [0001] The invention relates to a natural silk reinforced hydroxyapatite / chitosan composite membrane and a preparation method thereof, belonging to the field of biomedical materials. Background technique [0002] The chemical name of chitosan is (1-4)-2-amino-2-deoxy-β-D-glucose, it is the deacetylation product of chitin, and it is a rare positively charged alkaline polysaccharides. Because its degradation product is glucosamine, it is non-toxic, harmless, non-irritating to the human body and tissues, has good biocompatibility, and can promote the adhesion and proliferation of various tissue cells, so it has been widely used in the field of biomedicine. Especially chitosan basement membrane, in the treatment of periodontal disease, insufficient bone mass in dental implant areas, repair of other bone defects, fracture healing, etc., it is placed at the defect as a mechanical barrier membrane, It can selectively separate the surrounding soft tissue, prevent e...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61L31/04A61L31/02A61L31/00A61L31/14A61L31/16C08J5/18C08L5/08C08L89/00
CPCA61L31/005A61L31/028A61L31/042A61L31/14A61L31/148A61L31/16A61L2300/236A61L2300/30A61L2300/404A61L2300/602A61L2400/12C08J5/18C08J2305/08C08J2389/00C08J2405/08C08J2489/00C08L5/08
Inventor 唐硕蒋柳云马兵利汤春艳苏胜培
Owner HUNAN NORMAL UNIVERSITY
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com