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Application of cinnamate compounds in prevention and control of fungal diseases of crops

A technology of cinnamic acid esters and fungal diseases, which is applied in the field of pesticides, can solve the problems of crop injury and inhibit the normal growth of crops, and achieve the effect of avoiding injury and broad antibacterial spectrum

Active Publication Date: 2020-02-04
INST OF PLANT PROTECTION GANSU ACAD OF AGRI SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Triazoles include triadimefon, difenoconazole, tebuconazole, flusilazole, diniconazole, propiconazole, triconazole, hexaconazole, myclobutanil, triaconazole, etc. Due to long-term continuous use Drug resistance has been produced, and most varieties can easily cause phytotoxicity to crops due to improper use, inhibiting the normal growth of crops

Method used

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  • Application of cinnamate compounds in prevention and control of fungal diseases of crops
  • Application of cinnamate compounds in prevention and control of fungal diseases of crops
  • Application of cinnamate compounds in prevention and control of fungal diseases of crops

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Example 1 3-(3'-fluoro-4'-methoxyphenyl) ethyl acrylate, 3-(3',4'-methylenedioxyphenyl) ethyl acrylate, 3-(3 Determination of antibacterial activity of ',4'-dimethoxyphenyl) ethyl acrylate and reference compound A in vitro

[0026] (1) Test drug

[0027] 3-(3'-fluoro-4'-methoxyphenyl) ethyl acrylate (purity 99%), 3-(3',4'-methylenedioxyphenyl) ethyl acrylate (purity 99%) %) and 3-(3',4'-dimethoxyphenyl) ethyl acrylate (purity 99%), control compound A (3,4-dimethoxycinnamic acid methyl ester, purity 99%), 96.5% chlorothalonil (non-systemic broad-spectrum fungicide), 97.2% carbendazim (systemic broad-spectrum fungicide), 97.0% procymidone (systemic broad-spectrum fungicide), 96.0 % Dimetholine ((E,Z)-4-[3-(4-chlorophenyl)3-(3,4-dimethoxyphenyl)acryloyl]morpholine, systemic fungicide) Original drug, 97.0% azoxystrobin original drug (systemic broad-spectrum fungicide).

[0028] (2) Plant pathogenic fungi tested

[0029] Rhizoctonia solani, Phytophthora infestans, Valsa...

Embodiment 2

[0057] Example 2 3-(3',4'-methylenedioxyphenyl)ethyl acrylate and 3-(3',4'-dimethoxyphenyl)ethyl acrylate with metalaxyl, Determination of Combined Toxicity Effects of Mixed Use of Meiling on Phytophthora capsici

[0058] (1) Test drug

[0059] 3-(3',4'-methylenedioxyphenyl)ethyl acrylate, 3-(3',4'-dimethoxyphenyl)ethyl acrylate, 98% metalaxyl technical, 99% Hymexazol original drug.

[0060] (2) Plant pathogenic fungi tested

[0061] Phytophthora capsici P. capsici.

[0062] (3) Toxicity determination method

[0063] 3-(3',4'-methylenedioxyphenyl)ethyl acrylate, 3-(3',4'-dimethoxyphenyl)ethyl acrylate (A) and metalaxyl, For the mixed use of Mycomethazol (B), five mass ratios of 3:1, 2:1, 1:1, 1:2, and 1:3 are set, and each ratio is formulated to correspond to 6 to 8 concentration gradients. The combined virulence assay of Phytophthora capsici was carried out by using the growth rate method. For the specific assay method, refer to Example 1. Measure the colony diameter a...

Embodiment 3

[0073] Example 3 3-(3'-fluoro-4'-methoxyphenyl) ethyl acrylate, 3-(3',4'-methylenedioxyphenyl) ethyl acrylate, 3-(3 ', 4'-Dimethoxyphenyl) ethyl acrylate and reference compound A control and control zucchini powdery mildew in vivo assay

[0074] (1) Preparation method of emulsifiable cream

[0075] Weigh 4.59g of ethyl 3-(3'-fluoro-4'-methoxyphenyl)acrylate, dissolve it in 25mL of xylene, add 6g of emulsifier 0203B, stir and mix to obtain 14% 3-(3 '-Fluoro-4'-methoxyphenyl) ethyl acrylate EC.

[0076] Weigh 4.59g of ethyl 3-(3',4'-methylenedioxyphenyl)acrylate, dissolve it in 25mL of xylene, add 6g of emulsifier 0203B, stir and mix to obtain 14% 3-( 3',4'-Methylenedioxyphenyl) ethyl acrylate EC.

[0077] Weigh 3.16g of ethyl 3-(3',4'-dimethoxyphenyl)acrylate, dissolve it in 25mL of xylene, add 6g of emulsifier 0203B, stir and mix to obtain 10% 3-(3' , 4'-dimethoxyphenyl) ethyl acrylate EC.

[0078] Weigh 4.59g of reference compound A, dissolve it in 25mL of xylene, add 6g...

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Abstract

The invention discloses an application of cinnamate compounds in prevention and control of fungal diseases of crops. The cinnamate compounds have one of chemical structures represented by formulas shown in the description. The cinnamate compounds have strong antibacterial activity, have a wide antibacterial spectrum on pathogenic fungi of crops, are safe to crops in order to avoid phytotoxicity, and have better or equivalent field pesticide effect than a control compound 3, 4-dimethoxycinnamate when used to prevent and control fungal diseases of crops, such as powdery mildew, damping-off, rot,gummy stem blight, anthracnose, white rot, leaf blight, late blight, gray mold, phytophthora, Fusarium Patch, early blight, blight, full rot, pythium rot, dry rot, ring rot, banded sclerotial blightand Sclerotinia sclerotiorum.

Description

technical field [0001] The invention belongs to the field of pesticides, and in particular relates to the application of a cinnamate compound in preventing and treating fungal diseases of crops. Background technique [0002] As early as 1970, Staples et al. reported that the cinnamic acid derivative 3,4-dimethoxycinnamic acid methyl ester had fungicidal activity, and its cis-isomer was used as a pesticide in Japan, while the trans-isomer was almost inactive[①Staples M.V. , et al. Sci., 1970, 170:539-540; ② Tetsu, T. et al. Ann. Phytopathol. Soc. Jpn., 1996, 62: 222-227]. In the 1980s, on the basis of 3,4-dimethoxycinnamic acid methyl ester, the researchers of Shell company successfully developed the fungicide dimethomorph, which is also active in cis [①TetsuT., et al.Ann. Phytopathol. Soc. Jpn., 1996, 62: 222-227; ② Albert A. et al. Brighton: British Crop Prot. Council, 1988, 17-23]. Although it has been reported in the literature that dimethomorph has good protective and ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N43/30A01N37/38A01N37/46A01N43/80A01P3/00
CPCA01N43/30A01N37/38A01N37/46A01N43/80A01N37/40
Inventor 胡冠芳王玉灵刘映前余海涛牛树君刘敏艳赵峰
Owner INST OF PLANT PROTECTION GANSU ACAD OF AGRI SCI
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