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Photocurable hydrogel for preparing cytoskeleton

A cell scaffold and light-curing technology, applied in medical science, prosthesis, etc., can solve the problems of unsatisfactory stability, poor swelling performance, and sensitivity to external environmental stimuli, and achieve good elastic modulus and swelling performance. Hydrophilic, good hydrophilic effect

Active Publication Date: 2020-02-04
NANFANG HOSPITAL OF SOUTHERN MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The hydrogel is formed by physical cross-linking through intermolecular interactions, which is sensitive to external environmental stimuli, has poor swelling performance, and cannot meet the requirements of stability.

Method used

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  • Photocurable hydrogel for preparing cytoskeleton
  • Photocurable hydrogel for preparing cytoskeleton
  • Photocurable hydrogel for preparing cytoskeleton

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] (a) Preparation of unsaturated polyester

[0027] 2g (0.001mol) polyethylene glycol monomethyl ether with a molecular weight of 2000, 2g (0.02mol) succinic anhydride, 0.93g (0.005mol) 2-ethylhexyl glycidyl ether, 2.13g (0.015mol) methyl Add glycidyl acrylate and 43.8mg (0.2mmol) zinc acetate to 10mL DMF, heat up to 100°C for ring-opening polymerization for 10h under nitrogen protection, cool down to room temperature, and add cold ether to precipitate.

[0028] The infrared spectrum of the unsaturated polyester obtained above was measured by Shimadzu FTIR-8100 infrared spectrometer. The detection found that its IR(v -1 , KBr) are 3124, 2752, 1987, 1758, 1603, 1200, 1182, 989, 692cm -1 . The absorption peak at 3124 corresponds to the C-H stretching vibration peak on the allyl group, 2752cm -1 Corresponding to saturated C-H stretching vibration peak, 1758cm -1 Corresponding to the stretching vibration peak of the carbonyl group in the ester bond, 1603cm -1 Correspond...

Embodiment 2

[0080] (a) Preparation of unsaturated polyester

[0081] 2g (0.001mol) polyethylene glycol monomethyl ether with a molecular weight of 2000, 5g (0.05mol) succinic anhydride, 3.72g (0.02mol) 2-ethylhexyl glycidyl ether, 4.26g (0.03mol) methyl Add glycidyl acrylate and 109.5mg (0.5mmol) zinc acetate to 20mL DMF, heat up to 90°C under nitrogen protection for ring-opening polymerization for 8h, cool down to room temperature, add cold ether to precipitate.

[0082] The infrared spectrum of the unsaturated polyester obtained above was measured by Shimadzu FTIR-8100 infrared spectrometer. The detection found that its IR(v -1 , KBr) are 3257, 2876, 1987, 1864, 1611, 1242, 1109, 942, 724cm -1 . The absorption peak at 3257 corresponds to the C-H stretching vibration peak on the allyl group, 2876cm -1Corresponding to saturated C-H stretching vibration peak, 1864cm -1 Corresponding to the stretching vibration peak of the carbonyl group in the ester bond, 1611cm -1 Corresponding to t...

Embodiment 3

[0109] (a) Preparation of unsaturated polyester

[0110] 2g (0.001mol) polyethylene glycol monomethyl ether with a molecular weight of 2000, 3g (0.03mol) succinic anhydride, 1.86g (0.01mol) 2-ethylhexyl glycidyl ether, 2.84g (0.02mol) methyl Glycidyl acrylate and 87.6 mg (0.4 mmol) of zinc acetate were added to 15 mL of toluene, heated to 85 ° C under nitrogen protection for ring-opening polymerization for 6 h, cooled to room temperature, and precipitated by adding cold ether.

[0111] The infrared spectrum of the unsaturated polyester obtained above was measured by Shimadzu FTIR-8100 infrared spectrometer. The detection found that its IR(v -1 , KBr) is 3286, 2869, 1918, 1864, 1654, 1207, 1141, 954, 687cm -1 . The absorption peak at 3286 corresponds to the C-H stretching vibration peak on the allyl group, 2869cm -1 Corresponding to saturated C-H stretching vibration peak, 1864cm -1 Corresponding to the stretching vibration peak of the carbonyl group in the ester bond, 165...

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Abstract

The invention relates to a photocurable hydrogel for preparing a cytoskeleton. According to weight ratios, the photocurable hydrogel comprises an unsaturated polyester, diacrylate which is 1-2 times of the weight of the unsaturated polyester, acrylate which is 2-4 times of the weight of the unsaturated polyester, and a light initiator which is 0.1-0.5 time of the weight of the unsaturated polyester, wherein the unsaturated polyester is prepared from succinic anhydride, 2-ethylhexyl glycidyl ether, glycidyl methacrylate and zinc acetate through ring-opening polymerization under initialization of polyethylene glycol monomethyl ether. The cytoskeleton prepared after the photocurable hydrogel provided by the invention is cured has good hydrophilicity and significant effects in promoting cell adhesion and proliferation.

Description

technical field [0001] The present invention relates to a prosthetic material characterized by its function or physical properties, in particular to a polymer hydrogel, which is suitable for preparing cell scaffolds. Background technique [0002] Medical hydrogel is a kind of three-dimensional network containing a large amount of water inside, which can hold a large amount of water in water to swell without dissolving. Medical hydrogels are similar to body tissues and show good biocompatibility when in contact with blood, body fluids and human tissues, and their degradation products are not harmful to the body, so this type of material is widely used in tissue engineering, drug mitigation release, cell culture scaffolds and other fields. [0003] The cell scaffold provides nutrients for cell proliferation, performs gas exchange, discharges waste, and plays an important role in providing a place for cell proliferation and reproduction. Therefore, the cell scaffold must not ...

Claims

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Application Information

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IPC IPC(8): C08F283/01C08F222/20C08F222/14C08F220/20C08F220/18C08F220/28C08F220/68C08F2/48A61L27/52A61L27/58A61L27/50A61L27/16
CPCC08F283/01C08F2/48A61L27/52A61L27/58A61L27/50A61L27/16C08F220/20
Inventor 吴旭屠以诺李想陈旭源
Owner NANFANG HOSPITAL OF SOUTHERN MEDICAL UNIV
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