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Production method and application of porous polymer microneedle

A porous polymer and polymer technology, applied in the direction of microneedles, medical devices, non-active components of polymer compounds, etc., can solve the complex preparation process of porous polymer microneedles, difficulties in large-scale production and application, size and distribution Difficult to control and other problems, to achieve the effects of good controllability of pore size and distribution, high drug loading, and low cost

Active Publication Date: 2020-02-28
HUAZHONG UNIV OF SCI & TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] In view of the above defects or improvement needs of the prior art, the object of the present invention is to provide a method for preparing porous polymer microneedles and its application, wherein the overall process design of the preparation method and key freeze-drying technical steps The related conditions and parameters (such as the pressure during freeze-drying) are improved, which can effectively adjust the properties such as the pore structure, size and distribution of the prepared porous polymer microneedles; Porous polymer microneedles can be prepared on a large scale, which can solve the complex preparation process of porous polymer microneedles, harsh conditions, cumbersome processes, high prices, difficult control of pore structure, size and distribution, and difficulties in large-scale production and application. question

Method used

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  • Production method and application of porous polymer microneedle
  • Production method and application of porous polymer microneedle
  • Production method and application of porous polymer microneedle

Examples

Experimental program
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Effect test

Embodiment 1

[0035] A porous polymer microneedle array prepared by freeze-drying technology is prepared according to the following method: first, a PDMS (polydimethylsiloxane) negative mold is prepared by a micro-template method, and the negative mold is placed in dimethyl sulfoxide Take it out after immersing in the medium for 2 hours, remove the excess dimethyl sulfoxide on the surface of the female mold; then, drop the dimethyl sulfoxide solution of cellulose acetate with a molecular weight of 10kDa and a mass fraction of 30% onto the female mold, and place In a beaker with dimethyl sulfoxide, after ultrasonication for 1 hour, freeze in the refrigerator and place in a freeze dryer at 25°C, 10 -9 freeze-drying under Pa, and demoulding to obtain porous cellulose acetate microneedles.

[0036] The porous cellulose acetate microneedles obtained in this example have a pore size of 10 nm.

[0037] The parameters, conditions, etc. used in Embodiment 2 to Embodiment 14 are shown in the followi...

Embodiment 15

[0042] Example 15 Simulate the experiment of absorbing interstitial fluid

[0043] Porous cellulose acetate (CA) microneedles were prepared by the method of Example 1, inserted into a pre-prepared 3% agar hydrogel containing 1 mg / mL rhodamine B, and observed under a microscope.

[0044] Under the microscope, it can be clearly seen that the needle tip of the porous cellulose acetate microneedle is white before being inserted into the agar gel, and turns red after being inserted. The red color is the color of the model molecule rhodamine B, indicating that the porous polymer microneedle can absorb the model drug molecular.

Embodiment 16

[0045] Embodiment 16 animal skin experiment

[0046] Porous cellulose acetate (CA) microneedles were prepared using the method of Example 1, and rhodamine B was loaded in the porous microneedles, which were inserted into the flat fresh mouse skin that had been depilated in advance, and after a period of time Mouse skin was observed under a fluorescent microscope.

[0047] It was observed under an optical microscope that there were obvious holes on the surface of the treated mouse skin, and the rest of the skin was intact, indicating that the porous polymer microneedles could effectively pierce the mouse epidermis. Similarly, it can be observed under the fluorescence microscope that the surface of the mouse skin after the treatment has obvious green fluorescence, and other parts are black, indicating that the green fluorescence is caused by the rhodamine B remaining in the microneedle after the porous polymer microneedle pierces the skin. The hole formed at the lower part of t...

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Abstract

The invention discloses a production method and application of a porous polymer microneedle. The production method includes the steps of firstly, dissolving polymer into a solvent to obtain a polymersolution; secondly, filling the polymer solution into a microneedle mould; thirdly, freezing the whole microneedle mould filled with the polymer solution; fourthly, using freeze drying treatment to remove the solvent contained in the frozen microneedle to obtain the porous polymer microneedle, wherein the freeze drying treatment is performed under the pressure intensity of 0-100Pa. The productionmethod has the advantages that large-scale porous polymer microneedle production can be achieved by the simple and mild freeze drying technology, the technical problems that the production process ofthe porous polymer microneedle is complex, harsh in conditions, expensive, hard in pore structure, size and distribution control and difficult in large-scale production and application and the like can be solved; the produced porous polymer microneedle is applicable to tissue fluid extraction and transdermal drug delivery.

Description

technical field [0001] The invention belongs to the field of biomedical polymer materials, and more specifically relates to a method for preparing porous polymer microneedles and its application. The preparation method uses freeze-drying technology to prepare porous polymer microneedles, and is especially suitable for preparing porous polymer The material microneedle array, the prepared porous polymer microneedle can be applied to the preparation of preparations for extracting skin tissue fluid or blood or the preparation of pharmaceutical preparations for transdermal administration. Background technique [0002] Microneedles are three-dimensional array structures made of silicon, metal, and polymers with a length of 25–2000 μm and tapered tips. Microneedle is a new type of minimally invasive drug delivery tool in the field of biomedicine, which can enhance the effect of skin drug delivery through the epidermis and dermis of the skin. In recent years, microneedles have attr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K47/32A61K47/34A61K47/38A61K47/10A61K47/36A61K47/42A61K35/14A61P17/00A61P17/18A61P3/10A61P17/06A61P17/14A61P35/00A61M37/00
CPCA61K9/0021A61K35/14A61K47/10A61K47/32A61K47/34A61K47/36A61K47/38A61K47/42A61M37/0015A61M2037/0053A61M2037/0061A61P3/10A61P17/00A61P17/06A61P17/14A61P17/18A61P35/00
Inventor 朱锦涛柳佩田迪王华张连斌杜虹瑶陶娟李钰策
Owner HUAZHONG UNIV OF SCI & TECH
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