A kind of preparation method of sulfasalazine intermediate

A technology for sulfasalazine and intermediates, applied in the field of preparation of sulfasalazine intermediates, can solve the problems of increased production cost, complicated production process, long production time and the like, and has the advantages of short reaching time, low process temperature and low manufacturing cost. low effect
CN110862345BActive Publication Date: 2022-03-11SUZHOU HUANGHE PHARMA CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
SUZHOU HUANGHE PHARMA CO LTD
Publication Date
2022-03-11
Patent Text Reader

Abstract

The present invention provides a kind of preparation method of sulfasalazine intermediate, and its preparation method comprises the following steps: Step 1: add 4-amino-7-chloroquinoline in the mixing container that organic solvent is housed, add to described mixing container Inert gas is introduced into the medium, and the temperature is raised to 65-75°C; Step 2: After stirring for a certain period of time, add side chains and catalysts to the mixing container, continue to heat up to 85±3°C, and continue to stir; Step 3: Wait for the reaction After the end, cool down to 10±2°C and stand for separation to obtain the hydroxychloroquine matrix; Step 4: add sulfate solution to the hydroxychloroquine matrix, stir for 3.5-5 hours, and separate the solids in the solution, and further bake Dry access to hydroxychloroquine sulfate material. The preparation method of the sulfasalazine intermediate of the present invention has a simple preparation process and is suitable for popularization and use.
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Description

technical field

[0001] The invention provides a preparation method of a sulfasalazine intermediate, which belongs to the technical field of chemical industry. Background technique

[0002] Sulfasalazine (SASP), also known as 5-[p-(2-pyridinesulfamoyl)benzene]azosalicylic acid. Molecular formula is C18H14N4O5S, molecular weight: 398.39.

[0003] Sulfasalazine is an azo compound of salicylic acid and sulfapyridine, which has antibacterial, antirheumatic and immunosuppressive effects. In the intestinal tract, it is decomposed by the bacteria there into sulfapyridine (SP) and 5-aminosalicylic acid (5-ASA).

[0004] The current method for producing sulfasalazine needs to be mixed and manufactured through various intermediates, and some catalysts or solvents with chronic toxicity need to be added, which is not friendly to the environment and increases production costs; in addition, the production process is more cumbersome and the production time is longer. Long, not conducive ...

Claims

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