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Tacrolimus eye drop

A technology of tacrolimus and eye drops, applied in the field of pharmaceutical chemicals, can solve the problems of hidden eye damage and inability to use for a long time

Inactive Publication Date: 2020-03-10
李达欣
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to solve the problem that traditional eye drops have hidden damage to the eyes and cannot be used for a long time, and provide a kind of tacrolimus eye drops

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] A tacrolimus eye drop, comprising the following components and weight ratio: 120% water, 80% tacrolimus, 75% sodium deoxycholate, 55% polyvinyl alcohol, 50% genistein, 25% sodium chloride, Capric triglyceride 23, hypromellose 19, potassium dihydrogen phosphate 17, ethyl acetate 16, soybean lecithin 13, egg yolk lecithin 12, polyethylene glycol 12, xanthan gum 9, glyceryl behenate 8. Povidone 6. Benzalkonium Chloride 3.

Embodiment 2

[0015] A tacrolimus eye drop, comprising the following components and weight ratios: water 115, tacrolimus 76, sodium deoxycholate 63, polyvinyl alcohol 49, genistein 42, sodium chloride 23, Capric triglyceride 19, hypromellose 17, potassium dihydrogen phosphate 16, ethyl acetate 13, soybean lecithin 12, egg yolk lecithin 11, polyethylene glycol 9, xanthan gum 8, glyceryl behenate 6. Povidone 5. Geminidrine 2.

Embodiment 3

[0017] A tacrolimus eye drop, comprising the following components and weight ratio: 100-120 water, 60 tacrolimus, 50 sodium deoxycholate, 40 polyvinyl alcohol, 30 genistein, sodium chloride 20. Capric triglyceride 18, hypromellose 15, potassium dihydrogen phosphate 13, ethyl acetate 10, soybean lecithin 10, egg yolk lecithin 10, polyethylene glycol 8, xanthan gum 6, behenic acid Glyceride 5, Povidone 4, Sorbitol 1.

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PUM

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Abstract

The invention discloses a tacrolimus eye drop, and belongs to the field of pharmaceutical chemicals. The tacrolimus eye drop contains the following components in parts by weight: 100-120 parts of water, 60-80 parts of tacrolimus, 50-75 parts of sodium deoxycholate, 40-50 parts of polyvinyl alcohol, 30-50 parts of genistein, 20-25 parts of sodium chloride, 18-23 parts of capric triglyceride, 15-19parts of hydroxypropyl methylcellulose, 13-17 parts of potassium dihydrogen phosphate, 10-16 parts of ethyl acetate, 10-13 parts of soybean phospholipid, 10-12 parts of egg yolk lecithin, 8-12 parts of polyethylene glycol, 6-9 parts of xanthan gum, 5-8 parts of glyceryl behenate, 4-6 parts of povidone, 1-3 parts of a preservative agent. The tacrolimus eye drop provided by the invention solves theproblem that a traditional eye drop has hidden damage to eyes and cannot be used for a long time.

Description

technical field [0001] The invention relates to the field of medicinal chemicals, in particular to a tacrolimus eye drop. Background technique [0002] Due to the unique structure of the eye (the surface layer of the cornea is lipophilic, the inner layer is hydrophilic, and the blood-retinal barrier) and physiological functions (tear elution, tear dilution, nasolacrimal duct drainage, etc.), traditional eye drops have corneal Poor permeability, low bioavailability and other problems, and frequent application of eye drops in order to increase drug concentration and residence time will lead to poor patient tolerance and even ocular surface toxicity. [0003] Tacrolimus (Tacrolimus, FK506) is a new type of macrolide immunosuppressant, which belongs to calmodulin phosphatase inhibitor. Its immunosuppressive mechanism is similar to that of cyclosporine A, but the effect of inhibiting T cells is 10 to 100 times that of cyclosporine A. Tacrolimus is widely used clinically in the ...

Claims

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Application Information

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IPC IPC(8): A61K31/765A61K31/575A61K31/436A61K31/352A61K9/08A61K47/02A61K47/14A61K47/38A61K47/24A61K47/10A61K47/36A61K47/32A61P27/02
CPCA61K9/0048A61K9/08A61K31/352A61K31/436A61K31/575A61K31/765A61K47/02A61K47/10A61K47/14A61K47/24A61K47/32A61K47/36A61K47/38A61P27/02A61K2300/00
Inventor 李达欣
Owner 李达欣
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