Unlock instant, AI-driven research and patent intelligence for your innovation.

Acarbose sustained release preparation and preparation method thereof

A technology for acarbose and sustained-release preparations, applied in the field of acarbose sustained-release preparations and its preparation, can solve the problems of short drug effect duration, curative effect impact, easy to forget to take and miss doses, etc., to achieve sustained drug effect The effect of long-lasting, fast-acting drug effect, and low technical difficulty

Inactive Publication Date: 2020-03-24
湖北欣泽霏药业有限公司
View PDF5 Cites 4 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, because it is a common preparation, the drug release is too fast, the blood drug concentration is too high immediately, and the blood drug concentration is too low after short-term metabolism. would make the duration of the drug effect too short
In addition, patients need to take it three times a day, which is extremely inconvenient, and it is easy to forget to take and miss a dose, which will affect the curative effect.
[0005] Aiming at the problems existing in acarbose oral immediate-release preparations, a research team improved and disclosed an acarbose osmotic pump tablet and its preparation method. Since the osmotic pump uses an organic solvent in the preparation process, The requirements for clothing equipment are very high, and the precision of laser drilling is also very high, the preparation process is difficult, and the osmotic pump has certain instability in the body, mainly because its release hole is easy to block in the body
[0006] In addition, the osmotic pump has the obvious characteristics of time lag, which will lead to the disadvantage of not timely reducing blood sugar

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Acarbose sustained release preparation and preparation method thereof
  • Acarbose sustained release preparation and preparation method thereof
  • Acarbose sustained release preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Such as figure 1In the shown acarbose sustained-release preparation 1, the sustained-release core contains 20% acarbose, 40% matrix material, 35% release modifier, 4.9% release lubricant, and 0.1% release pigment. The immediate-release outer layer contains 20% of acarbose, 39.9% of filler, 20% of internally added disintegrant, 20% of externally added disintegrator, and 0.1% of immediate-release lubricant.

[0050] Example 1

[0051]

[0052] The specific preparation method is as follows:

[0053] (1) dry granulate after mixing acarbose, skeleton material, release regulator, and release pigment, and mix the prepared granules with a release lubricant to obtain a slow-release core material;

[0054] (2) dry granulate after mixing acarbose, filler, and internally added disintegrant, and mix the prepared granules with externally added disintegrant and immediate-release lubricant to obtain an immediate-release outer layer material;

[0055] (3) compressing the slow-rele...

Embodiment 2

[0058] Acarbose sustained-release preparation 2, the sustained-release core contains 50% acarbose, 20% matrix material, 27% release modifier, 2.5% release lubricant, and 0.5% release pigment. The immediate-release outer layer contains 50% of acarbose, 30% of filler, 12% of internally added disintegrant, 5% of externally added disintegrator, and 3% of immediate-release lubricant.

[0059] Example 2

[0060]

[0061]

[0062] The specific preparation method is as follows:

[0063] (1) dry granulate after mixing acarbose, skeleton material, release regulator, and release pigment, and mix the prepared granules with a release lubricant to obtain a slow-release core material;

[0064] (2) compressing the sustained-release core material into tablets to obtain a sustained-release tablet core;

[0065] (3) Dry granulate after mixing acarbose, filler, and internally added disintegrant, and mix the prepared granules with externally added disintegrant and immediate-release lubrica...

Embodiment 3

[0068] Acarbose sustained-release preparation 3, the sustained-release core contains 29.9% of acarbose, 50% of matrix material, 20% of release modifier, and 0.1% of release lubricant. The immediate-release outer layer contains 40% of acarbose, 43% of filler, 5% of internal disintegrant, 10% of external disintegrator, 1% of immediate-release lubricant, and 1% of immediate-release pigment.

[0069] Example 3

[0070]

[0071]

[0072] The specific preparation method is as follows:

[0073] (1) Dry granulate after mixing acarbose, skeleton material and release regulator, and mix the prepared granules with a release lubricant to obtain a slow-release core material;

[0074] (2) Dry granulate after mixing acarbose, filler, internal disintegrant, and immediate-release pigment, and mix the prepared granules with external disintegrant and immediate-release lubricant to obtain an immediate-release outer layer materials;

[0075] (3) compressing the slow-release inner core mate...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to the field of pharmaceutical preparations, in particular to an acarbose sustained release preparation and a preparation method thereof. The acarbose sustained release preparation is a core-coated tablet formed by a sustained-release inner core and a quick-release outer layer, wherein the slow-release inner core is an inner core, and the quick-release outer layer is used forwraping the outer layer of the slow-release inner core; both the slow-release inner core and the quick-release outer layer contain acarbose; and the mass ratio of acarbose in the slow-release inner core to acarbose in the quick-release outer layer is 5: 1-25. The method comprises the following steps: tabletting a slow-release inner core material to obtain the slow-release inner core, and performing secondary tabletting on a quick-release outer layer material and the slow-release inner core to form the core-coated tablet from the slow-release inner core and the quick-release outer layer, namely the acarbose sustained release preparation. The acarbose sustained release preparation disclosed by the invention is higher in safety, can achieve effect quickly and has a long-lasting drug effect.The preparation method of the acarbose sustained release preparation mainly comprises granulation and tabletting processes, does not involve operations such as laser drilling, is low in technical difficulty, and is convenient for industrial production.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to an acarbose sustained-release preparation and a preparation method thereof. Background technique [0002] There are about 114 million type 2 diabetes patients and nearly 150 million pre-diabetic patients in my country, which has become the country with the largest number of diabetic patients. Patients with type 2 diabetes are generally treated with oral hypoglycemic drugs. From the statistical analysis of market sales, the top three types of hypoglycemic drugs are acarbose, repaglinide and metformin. [0003] Acarbose is an alpha-glucosidase inhibitor that competitively inhibits glucoside hydrolase in the gut. Reduce the decomposition of polysaccharides and sucrose into glucose, so that the absorption of sugar is correspondingly slowed down, so it can have the effect of lowering blood sugar after meals. Generally used alone, or in combination with other oral hypoglyce...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/26A61K9/16A61K47/38A61K47/04A61K47/32A61K31/7036A61P3/10
CPCA61K9/1611A61K9/1635A61K9/1652A61K9/1682A61K9/2077A61K31/7036A61P3/10
Inventor 李永进陈言德
Owner 湖北欣泽霏药业有限公司