Immunochemotherapy pharmaceutical composition and preparation method therefor

A technology for chemoimmune and chemotherapeutic drugs, applied in drug combinations, pharmaceutical formulations, anti-tumor drugs, etc., can solve problems such as damage to normal organs, high toxicity and side effects of chemotherapy, and low clinical response rates.

Active Publication Date: 2020-03-27
SUZHOU INNOVATIVE BIOMATERIALS & PHARM CO LTD
View PDF3 Cites 6 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, traditional chemotherapy drugs can also damage normal organs, and the commonly used chemotherapy mode in clinic is systemic administration, which is not very selective for the lesion, and the side effects of chemotherapy are very serious
[0003] Although tumor immunotherapy represented by immune checkpoint blockade has made encouragi

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Immunochemotherapy pharmaceutical composition and preparation method therefor
  • Immunochemotherapy pharmaceutical composition and preparation method therefor
  • Immunochemotherapy pharmaceutical composition and preparation method therefor

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0135] Example 1: Preparation and use of lyophilized powder injection of sodium alginate (first component) and imiquimod (third component) hydrochloride composition

[0136] Step 1: Preparation of Imiquimod (the third component) hydrochloride. Weigh 50-100 mg of imiquimod in a 50 ml glass mixing container, add 1 ml of 1M dilute hydrochloric acid to it, and after the white powdery imiquimod is fully dissolved to colorless and transparent, add deionized water to dilute it so that The final concentration of imiquimod is 2.5-5 mg / ml. The solution was lyophilized to obtain imiquimod hydrochloride lyophilized powder. The purpose of this step is to change the water-insoluble imiquimod into the water-soluble hydrochloride form. The lyophilization time is long enough to ensure the complete removal of hydrochloric acid residues.

[0137] Step 2: Preparation of the lyophilized powder injection of the composition of sodium alginate (the first component) and imiquimod (the third component) h...

Example Embodiment

[0151] Example 2: Lyophilized powder injection of the composition of sodium alginate (the first component) and CpG oligonucleotide (the third component)

[0152] Step 1: Preparation of freeze-dried powder injection of the composition of sodium alginate and CpG oligonucleotide

[0153] Weigh 10 to 80 mg of sodium alginate and 0.1 to 5 mg of CpG oligonucleotides and dissolve them in 1 ml of aqueous solution, fully shake until the solution is clear and transparent, and freeze-dry the solution to obtain a composition freeze-dried powder injection.

[0154] Figure 5 It is a scanning electron microscope picture of the composition after the freeze-dried powder injection is reconstituted into gel. It can be seen from the figure that the composition still has good gel forming ability after freeze-drying and reconstitution, and it can be seen from the electron microscope pictures that there are many micron-level pores after gelling, which is important for the sustained release of drugs.

[015...

Example Embodiment

[0163] Example 3: Lyophilized powder injection of the composition of sodium alginate (first component) and adriamycin hydrochloride (second component)

[0164] Step 1: Preparation of freeze-dried powder injection of the composition of sodium alginate and adriamycin hydrochloride:

[0165] Method 1: Weigh 20~80 mg of sodium alginate and 0.1~10 mg of doxorubicin hydrochloride and dissolve in 1 ml of aqueous solution, stir with a stirring paddle at a speed of 50 to 300 revolutions per minute until the solution is clear and transparent, and then The solution is freeze-dried to obtain the composition freeze-dried powder injection.

[0166] Method 2: Dissolve 0.1-10 mg of adriamycin hydrochloride in 1 ml of aqueous solution, stir with a stirring paddle at 50-300 rpm until the solution is clear and transparent, and then dissolve 10 to 80 mg of sodium alginate In the aqueous solution, drip the constantly stirring adriamycin hydrochloride solution at a volume ratio of 1:20 to ensure that the...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
Particle sizeaaaaaaaaaa
Login to view more

Abstract

The invention discloses an immunochemotherapy pharmaceutical composition. The immunochemotherapy pharmaceutical composition is formed by mixing a first mixture with a second mixture; the first mixturecontains immunoadjuvant imiquimod R837; the second mixture contains chemotherapeutic drug oxaliplatin which can cause immunogenicity death, and further contains poloxamer 188 and sodium alginate (ALG); the first mixture is an imiquimod emulsion obtained by mixing the imiquimod R837 with the poloxamer 188; imiquimod particles each have a particle size of 0.5-3 mum; the imiquimod emulsion undergoesmoist heat sterilization; and the second mixture is a mixture prepared in a manner that the sodium alginate (ALG) and the oxaliplatin are stirred and mixed with water, and filtration sterilization isperformed with a micrometer filter membrane. The new anti-cancer pharmaceutical composition can exert the synergistic anticancer effect, reduces the side effect, the cancer metastasis probability andthe cancer recurrence probability, and can inhibit the growth of a distant metastatic tumor and reduce the tumor recurrence probability through the immunoreaction while effectively killing a tumor insitu; and meanwhile, the production process is relatively optimal, and the product stability is high.

Description

technical field [0001] The present invention relates to the field of drugs for treating tumors, in particular to a drug composition for combination therapy with chemotherapy and immunity, as well as a preparation method and application. Background technique [0002] Chemotherapy is one of the three main treatment methods for clinical treatment of tumors. Most cancer patients need to receive a certain degree of chemotherapy. For those tumors that have a tendency to metastasize or have metastasized, chemotherapy is the main treatment. However, traditional chemotherapy drugs can also damage normal organs, and the commonly used chemotherapy mode in clinic is systemic administration, which is not very selective for the lesion, and the side effects of chemotherapy are very serious. [0003] Although tumor immunotherapy represented by immune checkpoint blockade has made encouraging achievements in recent years, this therapy still has important limitations, including low clinical re...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K39/39A61K31/555A61K31/704A61K31/513A61K31/675A61K39/395A61K47/36A61K47/10A61P35/00A61P35/04
CPCA61K39/39A61K31/555A61K31/704A61K31/513A61K31/675A61K47/36A61K47/10A61P35/00A61K2039/55511A61K45/06A61K2300/00
Inventor 刘庄许欢陶惠泉巢宇赵琪
Owner SUZHOU INNOVATIVE BIOMATERIALS & PHARM CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap