Control method for determining content of furfurylamine in furosemide

A technology of furosemide and medium furfurylamine, which is applied in the field of analytical chemistry, can solve the problems of increasing the risk of furosemide precipitation and blockage of instruments, and achieve the effects of ensuring effectiveness and safety, accurate quantification, and strong specificity
CN110954629AInactive Publication Date: 2020-04-03南京科宁检测科技有限公司
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
南京科宁检测科技有限公司
Publication Date
2020-04-03
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses an analysis method for determining the content of furfurylamine in furosemide, which comprises the following steps: dissolving furosemide with sodium hydroxide, neutralizing furosemide with hydrochloric acid, determining furosemide by high performance liquid chromatography, and taking a mixed solution of phosphate buffer salt and acetonitrile as a mobile phase by using a C18 chromatographic column. The invention provides a method for quickly determining furfurylamine in furosemide, which is strong in specificity, high in sensitivity, high in accuracy, simple and convenient to operate and capable of more effectively controlling the quality of furosemide.
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Description

technical field

[0001] The invention belongs to the technical field of analytical chemistry, in particular to an analytical method for determining furosemide content in furosemide by high performance liquid chromatography. Background technique

[0002] Furosemide, chemical name Furosemide. It is widely used clinically to treat edema associated with heart failure, and can also be used alone or in combination with other antihypertensive drugs to treat hypertension. Its structural formula is as follows:

[0003]

[0004] The synthesis of furosemide mostly uses furfurylamine and 2,4-dichloro-5-sulfonamidobenzoic acid as starting materials, and furosemide is obtained through the steps of substitution reaction and purification. The content of chloro-5-sulfonamidobenzoic acid was used to monitor the end point of the reaction, and the residual amount of furfurylamine was easily ignored. The structural formula of furfurylamine is as follows:

[0005] The rapid and accurate det...

Claims

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