High-connectivity gradient bionic artificial bone structure and preparation method thereof

Abstract

The invention relates to a high-connectivity gradient bionic artificial bone structure and a preparation method thereof, belonging to the field of medical artificial bones. The method is suitable forthe design of a gradient bionic artificial bone with three-period pores, and a plurality of holes which are communicated with one another are distributed completely or locally in the artificial bone;each of the pores has three dimensions periodically extending towards three peripheral axes, and pore sizes can be controlled through porosity; the porosity can reduce the elasticity modulus of a metal material, and avoid interfacial loosening, stress shielding and degradation or absorption of bone tissue caused by too high elasticity modulus of metal and the like. The artificial bone is printed and constructed layer by layer by using metal powder or a hydroxyapatite biological material in additive manufacturing; and holes in the surface of the artificial bone can promote interface osteogenesis, enhance interface fusion and induce osteogenic differentiation of backbone cells at an interface, and bone tissue and an artificial bone implant are combined more firmly.

Description

technical field [0001] The invention relates to the field of medical artificial bones, in particular to a highly connected gradient bionic artificial bone structure consistent with the modulus of human autologous bone and a preparation method thereof. Background technique [0002] About 400 million people around the world suffer from joint diseases. Every year, bone defects caused by external forces such as traffic accidents lead to more than 2 million bone replacement operations (data source: World Health Organization). Although autologous bone grafting and allogeneic bone grafting are effective methods for repairing bone defects, problems such as pain, infection, and immune rejection may occur, so artificial bone scaffolds have been developed rapidly. [0003] The stress conditions of artificial bone serving in the human body and the microenvironment of the organism are complex and changeable. The system composed of artificial bone and bone is at the material interface, an...

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Problems solved by technology

[0006] In summary, artificial bone implants have been relatively mature in clinical application, and the design process is simple. The method of artificial bone design with metal dense models has been widely used, and simple cell and truss structure arrays are gradually being used in clinical practice. There are applications, but the gradient structure of the bone has not been considered, and how to reduce the elastic modulus of the implant structure while ensuring strength and high connectivity needs to be studied urgently

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