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Preparation method of Thiessen polygonal bionic artificial bone structure based on broken bone surface

A Tyson polygon, artificial bone technology, applied in the field of medical artificial bone, to achieve the effect of improving bonding strength, alleviating mechanical loosening and subsidence, and alleviating osteolysis

Active Publication Date: 2020-04-10
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method avoids failure due to excessive modulus difference, but ignores the tissue growth at the fractured bone section and the gradient distribution of autogenous bone trabeculae

Method used

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  • Preparation method of Thiessen polygonal bionic artificial bone structure based on broken bone surface
  • Preparation method of Thiessen polygonal bionic artificial bone structure based on broken bone surface
  • Preparation method of Thiessen polygonal bionic artificial bone structure based on broken bone surface

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preparation example Construction

[0026] see Figure 1 to Figure 4 As shown, the preparation method of the Thiessen polygonal bionic artificial bone structure based on the fractured bone surface of the present invention is applicable to the structural design of the artificial bone implant with high connectivity gradient, comprising the following steps:

[0027] Step (1) Carry out computer tomography scanning or take pictures with a high-resolution camera to obtain a grayscale image of the broken bone section of the patient, extract the coordinates of the center point of the bone tissue, obtain the positions of blood vessels and tissues at both ends of the broken bone section, and derive the three-dimensional coordinates of the center of the tissue ;

[0028] Step (2) According to the three-dimensional coordinate position of the tissue center of the broken bone section, design the artificial bone implant so that the section of the artificial bone is the same as that of the autologous bone. Under the condition o...

Embodiment

[0033] see Figure 1 to Figure 4 As shown, the bionic artificial bone structure based on the fractured bone surface of the present invention is consistent with the human's own bone modulus, which is beneficial to the bionic processing of the bone implant structure, and replicates the characteristics of natural bone at all levels (such as microstructure, machinery, mass transport and biological properties), and has excellent cell penetration, nutrient diffusion and osteoconduction properties. The mechanical and fluid properties of the Thiessen polygonal artificial bone scaffold structure depend on the microscopic porous structure, the total porosity, which also depends on the microscopic bone index (trabecular thickness, trabecular gap and trabecular number), all of these indicators in the structure of the present invention are controllable during the design process. And the design based on the broken bone surface provides favorable growth conditions for the growth of bone tis...

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Abstract

The invention relates to a preparation method of a Thiessen polygonal bionic artificial bone structure based on a broken bone surface, belonging to the field of medical artificial bones. The method comprises the following steps: carrying out computed tomography scanning on a broken bone section of a patient or photographing the broken bone section by using a high-resolution camera to obtain a grayscale image; designing an artificial bone implant to enable the cross sections of the artificial bone and an autologous bone to be the same; regulating and controlling the thickness of bone trabeculaaccording to the bearing position of the bone implant on a human body so as to allow the height of the bone trabecula to be structurally consistent with the height of the autologous bone; printing theconstructed artificial bone layer by layer; and carrying out friction impact resistance tests and other tests on an artificial bone sample under a simulated real service condition, and determining parameters suitable for the artificial bone structure. According to the Thiessen polygonal bionic artificial bone structure based on the broken bone surface, the mechanical property life of the artificial bone is effectively prolonged, and subsequent bone tissue ingrowth is facilitated.

Description

technical field [0001] The invention relates to the field of medical artificial bones, in particular to a method for preparing a Thiessen polygonal bionic artificial bone structure based on broken bone surfaces. Background technique [0002] Bone is currently one of the most transplanted tissues in the human body, with an incidence rate of nearly 15%, and millions of fracture cases every year. Biological bone grafting and non-biological bone grafting are two repair methods of bone grafting. Pain, infection and immune rejection from biological bone grafts hamper its development. In this case, abiotic bone grafting has become the main choice for bone grafting, and it has been clinically proven that most common scaffolds lack sufficient mechanical strength and a suitable environment for vascularization. An optimal bone scaffold should possess all levels of autogenous bone properties (mechanical, biological, mass, transport, and microstructural geometric properties) for cell p...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/28A61F2/30
CPCA61F2/28A61F2/30942A61F2002/2835A61F2002/30199A61F2002/30784A61F2002/3093A61F2002/30943A61F2002/30948A61F2002/30985
Inventor 刘东妮马志超李伟智
Owner JILIN UNIV
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