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Preparation method of Thiessen polygonal bionic artificial bone structure based on broken bone surface

A Tyson polygon, artificial bone technology, applied in the field of medical artificial bone

Active Publication Date: 2021-09-14
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method avoids failure due to excessive modulus difference, but ignores the tissue growth at the fractured bone section and the gradient distribution of autogenous bone trabeculae

Method used

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  • Preparation method of Thiessen polygonal bionic artificial bone structure based on broken bone surface
  • Preparation method of Thiessen polygonal bionic artificial bone structure based on broken bone surface
  • Preparation method of Thiessen polygonal bionic artificial bone structure based on broken bone surface

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preparation example Construction

[0026] see Figure 1 to Figure 4 As shown, the preparation method of the Thiessen polygonal bionic artificial bone structure based on the fractured bone surface of the present invention is applicable to the structural design of the artificial bone implant with high connectivity gradient, comprising the following steps:

[0027] Step (1) Carry out computer tomography scanning or take pictures with a high-resolution camera to obtain a grayscale image of the broken bone section of the patient, extract the coordinates of the center point of the bone tissue, obtain the positions of blood vessels and tissues at both ends of the broken bone section, and derive the three-dimensional coordinates of the center of the tissue ;

[0028] Step (2) According to the three-dimensional coordinate position of the tissue center of the broken bone section, design the artificial bone implant so that the section of the artificial bone is the same as that of the autologous bone. Under the condition o...

Embodiment

[0033] see Figure 1 to Figure 4 As shown, the bionic artificial bone structure based on the fractured bone surface of the present invention is consistent with the human's own bone modulus, which is beneficial to the bionic processing of the bone implant structure, and replicates the characteristics of natural bone at all levels (such as microstructure, machinery, mass transport and biological properties), and has excellent cell penetration, nutrient diffusion and osteoconduction properties. The mechanical and fluid properties of the Thiessen polygonal artificial bone scaffold structure depend on the microscopic porous structure, the total porosity, which also depends on the microscopic bone index (trabecular thickness, trabecular gap and trabecular number), all of these indicators in the structure of the present invention are controllable during the design process. And the design based on the broken bone surface provides favorable growth conditions for the growth of bone tis...

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Abstract

The invention relates to a preparation method of a Thiessen polygonal bionic artificial bone structure based on a fractured bone surface, belonging to the field of medical artificial bones. The steps include computerized tomography scanning of the broken bone section of the patient or taking a photo with a high-resolution camera to obtain a grayscale image; designing the artificial bone implant so that the section of the artificial bone is the same as that of the autologous bone; adjusting the bone implant according to the load-bearing position of the human body The thickness of the trabecular bone is consistent with the height of the autogenous bone in structure; the artificial bone is printed layer by layer; the artificial bone sample is tested for friction and impact resistance under simulated real service conditions, and the parameters suitable for the artificial bone structure are determined. The Thiessen polygonal bionic artificial bone structure based on the fractured bone surface proposed by the present invention can effectively improve the mechanical performance and lifespan of the artificial bone and facilitate subsequent bone tissue ingrowth.

Description

technical field [0001] The invention relates to the field of medical artificial bones, in particular to a method for preparing a Thiessen polygonal bionic artificial bone structure based on broken bone surfaces. Background technique [0002] Bone is currently one of the most transplanted tissues in the human body, with an incidence rate of nearly 15%, and millions of fracture cases every year. Biological bone grafting and non-biological bone grafting are two repair methods of bone grafting. Pain, infection and immune rejection from biological bone grafts hamper its development. In this case, abiotic bone grafting has become the main choice for bone grafting, and it has been clinically proven that most common scaffolds lack sufficient mechanical strength and a suitable environment for vascularization. An optimal bone scaffold should possess all levels of autogenous bone properties (mechanical, biological, mass, transport, and microstructural geometric properties) for cell p...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G06F17/00A61F2/28A61F2/30
CPCA61F2/28A61F2/30942A61F2002/2835A61F2002/30199A61F2002/30784A61F2002/3093A61F2002/30943A61F2002/30948A61F2002/30985
Inventor 刘东妮马志超李伟智
Owner JILIN UNIV
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