Freeze-dried powder and preparation method thereof

A technology of freeze-dried powder and mother liquor, which is applied in the direction of pharmaceutical formulations, cosmetic preparations, dressing preparations, etc., can solve the problems of reducing the rate of sterile filtration, affecting the resolubility of freeze-dried powder, and increasing the difficulty of sterile filtration, etc., to achieve The price of raw materials is cheap, the requirements for professional quality are low, and the effect of smooth and delicate appearance

Active Publication Date: 2020-04-10
广州市阿西娜化妆品制造有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

From the formula level, increasing the consistency can certainly weaken the migration of pigments, but the increase in consistency also increases the difficulty of sterile filtration. Generally, the pore size of sterile filtration is small, and increasing the consistency greatly reduces the rate of sterile filtration. Even if it cannot be filtered, it is necessary to add preservatives or high-temperature sterilization to reduce the risk of bacterial contamination.

Method used

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  • Freeze-dried powder and preparation method thereof
  • Freeze-dried powder and preparation method thereof
  • Freeze-dried powder and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0024] Example 1

[0025] The purpose of this example is to compare the effect of the addition of betaine on the migration of colored substances (tripeptide-1 copper) during the freeze-drying process and other indicators

[0026] In this example, the three types of freeze-dried powders (numbered 2, 3, and 4) of the present invention and one type of freeze-dried powder without betaine (numbered 1, control group) were analyzed for the migration, appearance and appearance of colored substances. The detection or observation of resolubility, and the test of resolubility all used normal saline for dissolution test. The results are shown in Table 1.

[0027] The freeze-dried powder No. 1, in terms of weight percentage, the freeze-dried powder includes the following components: tripeptide-1 copper 1%, trehalose 1%, mannitol 8%, and deionized water 90%.

[0028] Number 2 freeze-dried powder, based on weight percentage, said freeze-dried powder includes the following components: tripeptide-1 co...

Example Embodiment

[0039] Example 2

[0040] The purpose of this example is to compare the effects of different mannitol concentrations in the freeze-dried powder on the migration, appearance and resolubility of colored substances in the freeze-dried powder

[0041] In this example, the three types of freeze-dried powder (numbered 2, 3, 4) and the freeze-dried powder of the control group (numbered 1 and 5) of the present invention were tested for the migration, appearance and resolubility of colored substances. Or observe that the resolubility test uses normal saline for dissolution test. The results are shown in Table 2.

[0042] The freeze-dried powder No. 1, in terms of weight percentage, the freeze-dried powder includes the following components: tripeptide-1 copper 0.5%, betaine 1%, trehalose 0.5%, mannitol 1%, deionized Water 97%.

[0043] Number 2 freeze-dried powder, based on weight percentage, said freeze-dried powder includes the following components: tripeptide-1 copper 0.5%, betaine 1%, treh...

Example Embodiment

[0055] Example 3

[0056] The purpose of this example is to compare the effects of the addition of trehalose and the concentration of tripeptide-1 copper itself on the migration of colored substance tripeptide-1 copper.

[0057] In this example, the 7 kinds of freeze-dried powder (numbered 1-7) and the freeze-dried powder (numbered 8) of the control group of the present invention were tested or observed for the migration, appearance and resolubility of colored substances. All the solubility tests used physiological saline for the dissolution test. The results are shown in Table 3.

[0058] The freeze-dried powder No. 1, in terms of weight percentage, the freeze-dried powder includes the following components: tripeptide-1 copper 0.5%, betaine 1%, trehalose 0.1%, mannitol 5%, deionized Water 93.4%.

[0059] Number 2 freeze-dried powder, based on weight percentage, the freeze-dried powder includes the following components: tripeptide-1 copper 0.5%, betaine 1%, trehalose 0.8%, mannitol 5...

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Abstract

The invention relates to freeze-dried powder and a preparation method thereof, belonging to the field of cosmetics. The freeze-dried powder provided by the invention comprises the following componentsin percentage by weight: 0.12% of copper tripeptide-1, 0.27% of a humectant, and 0.123% of an excipient, with the balance being deionized water. According to the invention, betaine with low consistency is used as a protective agent for resisting solute migration, and a weight ratio of betaine to copper tripeptide-1 is 3: 1, so the prepared freeze-dried powder has the advantages of no migration ofcolored substances, good stability, normal appearance and good re-solubility; the freeze-dried powder obtained after freeze-drying treatment is smooth and fine in appearance, good in reproducibilityand good in permeability; the freeze-dried powder is low in cost, cheap in raw material price; and the preparation method is simple in process, does not need complex equipment, has low requirement onthe occupational quality of operators, and is easy to implement and capable of being industrially popularized and produced on a large scale.

Description

technical field [0001] The invention relates to a freeze-dried powder and a preparation method thereof, belonging to the field of cosmetics. Background technique [0002] Freeze-dried powder is a sterile powder made by ultra-low temperature freezing process under vacuum conditions, and it is a beauty product with repairing effect. The preparation of freeze-dried powder includes the screening of formula and the design of freeze-drying process; a formula of freeze-dried powder with good effect can often get twice the result with half the effort, and can effectively reduce various abnormal phenomena during the freeze-drying process, and the finished product after freeze-drying The appearance, resolubility, moisture content, shelf life and glass transition temperature of the product are all in line with industry standards. The formula of the lyophilized powder includes excipients and active substances. According to the properties of the active substances, choosing a suitable ex...

Claims

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Application Information

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IPC IPC(8): A61K8/64A61K8/44A61K8/34A61K8/60A61K8/02A61Q19/00A61Q17/00A61P29/00
CPCA61K8/64A61K8/44A61K8/345A61K8/60A61K8/022A61Q19/00A61Q17/005A61P29/00A61K2800/84
Inventor 廖翠琴邝光林赵观胜
Owner 广州市阿西娜化妆品制造有限公司
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