Antibacterial and wound healing promotion composition and its medical hydrocolloid oil gauze

A wound healing and hydrocolloid technology, applied in the field of medical materials, can solve the problems of lack of cohesion and inability to remove the dressing as a whole, so as to broaden the range of antibacterial, promote Gram-positive bacteria, and inhibit Gram-negative bacteria Effect

Active Publication Date: 2022-05-20
GUANGZHOU RAINHOME PHARM&TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These dressings suffer from the following disadvantages: lack of cohesion; and excessive disintegration that occurs when exudate is absorbed, leaving debris on the wound and removal of the dressing as a whole
[0005] However, there is still room for improvement in the antibacterial and healing properties of hydrocolloid oil yarn

Method used

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  • Antibacterial and wound healing promotion composition and its medical hydrocolloid oil gauze
  • Antibacterial and wound healing promotion composition and its medical hydrocolloid oil gauze
  • Antibacterial and wound healing promotion composition and its medical hydrocolloid oil gauze

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Embodiment 1, antibacterial and promote wound healing composition

[0038] group composition Composition 1 Chitosan quaternary ammonium salt: PEG-400: sodium hyaluronate = 1:0.1:0.2 Composition 2 Chitosan quaternary ammonium salt: PEG-400: sodium hyaluronate = 1:0.4:0.3 Composition 3 Chitosan quaternary ammonium salt: PEG-600: sodium hyaluronate = 1:0.6:0.4 Composition 4 Chitosan quaternary ammonium salt Composition 5 Sodium hyaluronate Composition 6 PEG-400 Composition 7 Chitosan quaternary ammonium salt: PEG-400=1:0.1

Embodiment 2

[0039] Embodiment 2, preparation of gelatin microspheres embedding antibacterial and promoting wound healing compositions

[0040] S1. Weigh gelatin and composition 1, add it into deionized water, stir at 60°C until completely dissolved, and obtain a solution with a concentration of 10%, which is used as the water phase;

[0041] S2. Add 60ml of vegetable oil into the beaker, then add 2ml of the mixture composed of Span 80 and Tween 80 in a mass ratio of 5:1 as an emulsifier, mix and preheat to 60°C, as the oil phase;

[0042] S3. Slowly add the water phase obtained in step S1 into the oil phase obtained in step S2. The volume ratio of the water phase to the oil phase is 1:5, mix evenly, and emulsify at a speed of 800r / min and a water bath temperature of 50°C 15min, a homogeneous emulsion was obtained;

[0043] S4. After emulsification, cool for 5 minutes, add 1 ml of glutaraldehyde solution with a concentration of 50% dropwise, and cross-link and solidify for 30 minutes to o...

Embodiment 3

[0045] Embodiment 3, preparation of oxidized sodium alginate

[0046] a. Sodium alginate is fully dissolved in pure water to obtain a 5wt% sodium alginate solution;

[0047] b. Slowly add the sodium periodate solution with a concentration of 0.5mol / L to the sodium alginate solution obtained in step a according to the volume ratio of 0.5:1. After reacting for 10 hours at room temperature in the dark, add 1ml of ethylene glycol to terminate the reaction. Stir for 1 hour to obtain oxidized sodium alginate solution;

[0048] c. Spray-dry the oxidized sodium alginate solution obtained in step b to obtain oxidized sodium alginate particles.

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Abstract

The invention relates to the field of medicine and provides an antibacterial and wound healing promoting composition and its medical hydrocolloid oil gauze. The antibacterial and wound healing promoting composition of the present invention includes chitosan quaternary ammonium salt, polyethylene glycol and sodium hyaluronate , the mass ratio of the three is 1: (0.1-0.6): (0.2-0.4). The present invention uses gelatin to embed the above-mentioned antibacterial and wound healing composition to form microspheres and add it to the hydrocolloid oil yarn to form a compound that can inhibit Gram-negative bacteria and Gram-positive bacteria while having significant anti-inflammatory, The medical hydrocolloid oil gauze that promotes wound healing and repair has achieved remarkable progress compared with the prior art.

Description

technical field [0001] The invention relates to the technical field of medical materials, in particular to an antibacterial and wound healing promoting composition and medical hydrocolloid oil gauze thereof. Background technique [0002] As a wound cover, medical dressings can replace damaged skin as a temporary barrier during wound healing, play a role in controlling wound exudate, avoiding or controlling wound infection, and are conducive to wound healing. In recent years, the rapid development of science and technology has changed people's knowledge and understanding of the principles of wound healing and the process of wound care, and many new materials have been used in medical dressings on a large scale. For example, films, foams, hydrogels, alginates and hydrocolloids, and pharmaceuticals. [0003] Natural healing of wounds proceeds in three sequential phases, each characterized by specific cellular events: a debridement phase, a proliferative (or granulation) phase,...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/28A61L15/26A61L15/32A61L15/34A61L15/24A61L15/42A61L15/46C08B37/04C08G101/00
CPCA61L15/28A61L15/26A61L15/325A61L15/34A61L15/24A61L15/42A61L15/46C08B37/0084A61L2300/404A61L2300/41A61L2300/236A61L2300/412A61L2300/602C08G2101/00C08L5/08C08L71/02C08L5/04C08L1/286C08L53/02
Inventor 车七石单玲星陈良艳刘少辉
Owner GUANGZHOU RAINHOME PHARM&TECH CO LTD
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