Novel plasma perfusion resin for treating nephropathy, and preparation method and application thereof

The technology of plasma perfusion and plasma perfusion device is applied in the field of novel plasma perfusion resin for the treatment of nephropathy and its preparation, which can solve the problems of complex modification method and poor applicability, and achieves improvement of blood compatibility, inhibition of bacterial function, and good industrial application. Foreground effect

Pending Publication Date: 2020-04-14
TIANJIN CITY THIRD CENT HOSPITAL +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most of the modification methods are complicated, the process control is strict, and the applicability for large-scale industrial modification is poor.

Method used

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  • Novel plasma perfusion resin for treating nephropathy, and preparation method and application thereof
  • Novel plasma perfusion resin for treating nephropathy, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] The polystyrene-divinylbenzene resin (model HB-H-10-1) was rinsed with absolute ethanol for 72 hours to remove organic impurities in the plasma perfusion resin for the treatment of renal disease, and then rinsed with water for injection until neutral ; Then rinse with 5wt% NaOH solution for 72h until the NaOH solution flowing out after rinsing is clear, no peculiar smell and no fine resin, and then rinse with water for injection until neutral; then rinse with 5wt% HCl Wash for 72 hours until the HCl is clear, odorless and free of finely divided resin after rinsing, and then rinse with water for injection until neutral; then treat for 20 minutes at a temperature of 121 ° C and a pressure of 103.4 kPa for high temperature and high pressure sterilization to obtain Existing production process resin;

[0029] In a sterile environment, after sealing the existing production process resin, sterilized preservation solution and human serum albumin, mix them in a shaker at 37°C an...

Embodiment 2

[0047] The polystyrene-divinylbenzene resin (model HB-H-10-2) was rinsed with absolute ethanol for 24 hours to remove organic impurities in the plasma perfusion resin for the treatment of renal disease, and then rinsed with water for injection until neutral ; Then rinse with 5wt% NaOH solution for 24h until the NaOH solution flowing out after rinsing is clear, no peculiar smell and no fine resin, and then rinse with water for injection until neutral; then rinse with 5wt% HCl Wash for 24 hours until the HCl is clear, no peculiar smell, and no finely divided resin after rinsing, and then rinse with water for injection until neutral; then treat for 15 minutes at a temperature of 121 ° C and a pressure of 103.4 kPa for high temperature and high pressure sterilization to obtain Existing production process resin;

[0048] In a sterile environment, after sealing the existing production process resin, sterilized preservation solution and human serum albumin, mix for 4 hours in a shake...

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Abstract

The invention discloses novel plasma perfusion resin for treating nephropathy, and a preparation method and an application thereof. The preparation method comprises the following steps: sealing sterilized plasma perfusion resin for treating nephropathy, a sterilized preservation solution and human serum albumin in a sterile environment to obtain a system, uniformly mixing the system, coating the resin with human serum albumin, and taking out the coated resin to obtain the novel plasma perfusion resin for treating nephropathy. The application is characterized in that a plasma perfusion device is filled with the novel plasma perfusion resin for treating nephropathy in a sealed mode in the sterile environment, and then sterilization treatment is conducted for 10-15 h in a 60-65 DEG C constant-temperature environment to obtain a novel plasma perfusion device for treating nephropathy. The adsorbability of the resin to albumin is used, and the human serum albumin is added into the resin preservation solution to coat the resin, so that the blood compatibility of the resin is improved. Meanwhile, the removal effect of the resin on toxins such as creatinine and uric acid is not influenced.An existing plasma perfusion device is slightly adjusted, so complex chemical modification is avoided, and the micro-adjustment is simple, convenient and feasible.

Description

technical field [0001] The invention relates to the field of nephropathy treatment, in particular to a novel plasma perfusion resin for nephropathy treatment and a preparation method and application thereof. Background technique [0002] Chronic renal failure (CRF) is an advanced clinical syndrome composed of a variety of renal diseases, which can lead to symptoms such as anemia, nausea and vomiting, and oral ulcers. Its prominent features include water, electrolyte, acid-base imbalance, and metabolic disorders and toxin retention. CRF has an extremely long course and has a great impact on the quality of life of patients. It has become a major problem that threatens public health. [0003] Hemodialysis (HD) is the most common treatment for CRF patients. The main principle of HD treatment is diffusion. Small molecular substances and some medium molecular toxins in the patient's body can enter the dialysate through the hemodialysis membrane and be excreted from the body. The...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/75A61K47/42A61P13/12A61P7/08
CPCA61K31/75A61K47/42A61P13/12A61P7/08
Inventor 刘娟娟李涛李可郭红星舒桂明
Owner TIANJIN CITY THIRD CENT HOSPITAL
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