Method for simultaneously preparing rare ginsenoside and grease unsaponifiable matter

A technology for rare saponins and saponins of ginseng, which is applied in the directions of pharmaceutical formulations, plant raw materials, medical preparations containing active ingredients, etc., can solve the problems of wasting manpower and material resources, not seeing oil unsaponifiables and ginsenosides, and complicated operations.

Active Publication Date: 2020-04-17
CHANGCHUN NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The above-mentioned technology has the following defects: (1) when the existing method obtains the unsaponifiable matter in the oil, the oil is mostly used as the starting research material; After six steps of oil extraction from raw materials, concentratio

Method used

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  • Method for simultaneously preparing rare ginsenoside and grease unsaponifiable matter
  • Method for simultaneously preparing rare ginsenoside and grease unsaponifiable matter
  • Method for simultaneously preparing rare ginsenoside and grease unsaponifiable matter

Examples

Experimental program
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Effect test

Embodiment 1

[0032] Process dried ginseng into powder, take 5g, add 50mL petroleum ether, 1.0g sodium hydroxide, 25mL n-butanol, 50mL ethanol, 50mL water, extract with a stirring tank or a stirrer, stirring shaft speed: 120rpm, temperature: 140 degrees centigrade, heating time is 0.5 hour, stand still for 90 minutes after heating, take the upper layer solution, reduce pressure or normal pressure to concentrate, make ginseng oil unsaponifiable matter. Take the solution in the lower layer, concentrate it to 1 / 4 of the original volume, add 2.5g of macroporous resin, the type of macroporous resin is D101, first elute with water until the ethanol eluent is colorless, clear and transparent, with a pH value of 7, Then elute with ethanol solution with a volume ratio of 40%, until the ethanol eluate is colorless, clear and transparent, collect the ethanol eluate, recover ethanol, and dry to obtain rare ginseng saponins in the form of dry extract.

[0033] The ginseng oil unsaponifiables prepared in...

Embodiment 2

[0051] Process dried ginseng into powder, take 5g, add 100mL petroleum ether, 1.5g sodium hydroxide, 50mL n-butanol, 80mL ethanol, 150mL water, extract with a stirring tank or a stirrer, stirring shaft speed: 140rpm, temperature: 120 degrees centigrade, heating time is 1.0 hour, stand still for 150 minutes after heating, take the upper layer solution, reduce pressure or normal pressure to concentrate, obtain ginseng oil and fat unsaponifiable matter. Take the solution in the lower layer, concentrate to 1 / 5 of the original volume, add 5.0 g of macroporous resin, the type of macroporous resin is D130, first elute with water until the ethanol eluent is colorless, clear and transparent, with a pH value of 7, Then elute with ethanol solution with a volume ratio of 50%, until the ethanol eluate is colorless, clear and transparent, collect the ethanol eluate, recover ethanol, and dry to obtain rare ginseng saponins in the form of dry extract.

Embodiment 3

[0053] Process the dried ginseng into powder, take 5g, add 150mL petroleum ether, 2.0g sodium hydroxide, 80mL n-butanol, 150mL ethanol, 250mL water, extract with a stirring tank or a stirrer, the stirring shaft speed: 160rpm, and the temperature is: 105 degrees centigrade, heating time is 1.5 hours, stand still for 120 minutes after heating, take the upper layer solution, reduce pressure or normal pressure to concentrate, make ginseng oil unsaponifiable matter. Take the lower layer solution, concentrate it to 1 / 6 of the original volume, put it in 6.0g macroporous resin, the macroporous resin model is AB8, first elute with water until the ethanol eluent is colorless, clear and transparent, and the pH value is 7, Then elute with ethanol solution with a volume ratio of 50%, until the ethanol eluate is colorless, clear and transparent, collect the ethanol eluate, recover ethanol, and dry to obtain rare ginseng saponins in the form of dry extract.

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Abstract

The invention, which belongs to the field of ginseng extract preparation methods, provides a method for simultaneously preparing rare ginsenoside and a grease unsaponifiable matter. The method comprises the following steps: processing dried ginseng into powder, adding petroleum ether, sodium hydroxide, n-butyl alcohol, ethanol and water, and performing extracting by using a stirring device; afterextraction finishing, performing standing, taking an upper-layer solution, and performing concentrating under a reduced pressure or normal pressure to obtain a ginseng grease unsaponifiable matter; taking a lower-layer solution, performing concentrating, performing treatment with a macroporous resin column, performing eluting with water until an ethanol eluent is colorless, clear and transparent,performing eluting with an ethanol solution until the ethanol eluent is colorless, clear and transparent, collecting the ethanol eluent, recovering ethanol, and performing drying to obtain the dry extract-like rare ginsenoside. The method can be used for preparing rare ginsenoside and a grease unsaponifiable matter at the same time and is convenient, efficient, and easy to operate; the cost is low; and the utilization rate of ginseng is increased. The development and utilization requirements in the fields of medicines, foods and chemical engineering are met. The method for simultaneously preparing rare ginsenoside and a grease unsaponifiable matter has the great application and development values.

Description

technical field [0001] The invention belongs to the field of preparation methods of ginseng extracts, in particular to a method for simultaneously preparing rare ginseng saponins and oil unsaponifiables. Background technique [0002] Panax ginseng is the dried root of Panax ginseng C.A.Mey. Nature and flavor: sweet, slightly bitter, warm and flat. Return spleen, lung meridian, heart meridian. Invigorating qi, solidifying, promoting body fluid, calming the nerves, and improving intelligence. Indications: Deficiency of the body, cold limbs, slight pulse, spleen deficiency, lack of food, lung deficiency, wheezing and coughing, thirsty body fluid wound, internal heat and thirst, chronic illness and weakness, palpitations and insomnia, impotence and uterine cold; heart failure, cardiogenic shock. It is used for shortness of breath, palpitation, forgetfulness, excessive thirst and sweating, lack of appetite and weakness, all acute and chronic diseases and shock and collapse cau...

Claims

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Application Information

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IPC IPC(8): A61K36/258A61K125/00
CPCA61K36/258A61K2236/35A61K2236/51A61K2236/55
Inventor 李赛男刘春明王恩发张语迟时东方
Owner CHANGCHUN NORMAL UNIVERSITY
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