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Suppository carrying radioactive particles and preparation method of suppository

A technology of radioactive particles and suppositories, which is applied in the direction of radioactive preparations, radioactive carriers, and radioactive physical shapes in the body, which can solve the problems of easily damaged mucous membranes in the lumen and the inability to carry drugs, etc., and achieve the effect of convenient use

Active Publication Date: 2020-04-17
HTA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, at present, radioactive seeds for clinical use are mainly suitable for solid tumors implanted with radioactive seeds. For some lumen sites that are not suitable for puncture, radioactive particles cannot be directly used for brachytherapy because the radioactive particles cannot be fixed in the lesion. Need to use other means to achieve radioactive seed brachytherapy
[0005] Chinese patent applications CN2617400Y and CN107569766A provide a stent carrying radioactive particles for radioactive brachytherapy of tumors near the lumen. The support function of the stent can also solve the problem of stenosis of the lumen, but the mechanical support of the stent is easy to damage the lumen Inner mucosa, and the stent is generally a metal product, which itself does not have the function of carrying drugs, and the drug treatment matched with radioactive brachytherapy can only be implemented by other means

Method used

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  • Suppository carrying radioactive particles and preparation method of suppository
  • Suppository carrying radioactive particles and preparation method of suppository
  • Suppository carrying radioactive particles and preparation method of suppository

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Embodiment 1: suppository preparation embodiment (one)

[0050] 1. Preparation of suppository matrix sol

[0051] Matrix formula:

[0052]

[0053] Stir the above matrix formula at room temperature to prepare a uniform glue solution, and pour the glue solution into suppository molds.

[0054] 2. Preliminary curing of suppositories

[0055] Dissolve 1 gram of calcium chloride in 999 grams of purified water to obtain a low-concentration calcium ion solution. Soak the suppository mold in the low-concentration calcium ion solution and take it out after soaking at room temperature for 30 minutes.

[0056] 3. Insertion of radioactive particles

[0057] With radioactive particles (0.8 mCi 125 The puncture needle of I particle) is inserted into three rows of radioactive particles, and each row is placed two in parallel, and each suppository inserts six radioactive particles altogether.

[0058] 4. Complete curing of suppositories

[0059] Dissolve 10 grams of calcium c...

Embodiment 2

[0060] Embodiment 2: suppository preparation embodiment (two)

[0061] 1. Preparation of suppository matrix sol

[0062] Matrix formula:

[0063]

[0064] Stir the above matrix formula at 95°C to prepare a uniform glue solution, and pour the glue solution into suppository molds.

[0065] 2. Preliminary curing of suppositories

[0066] Cool the mold to 41°C for 10 minutes

[0067] 3. Insertion of radioactive particles

[0068] With radioactive particles (1.2 mCi 103 The puncture needle of Pd particle) is inserted into the suppository, and one radioactive particle is inserted into each suppository.

[0069] 4. Complete curing of suppositories

[0070] Cool the mold to room temperature. Take it out, demould it, pack it and store it in a refrigerator to form a suppository product carrying radioactive particles.

Embodiment 3

[0071] Embodiment 3: suppository preparation embodiment (three)

[0072] 1. Preparation of suppository matrix sol

[0073] Matrix formula:

[0074]

[0075] Stir the above matrix formula at 80°C to prepare a uniform glue solution, and pour the glue solution into suppository molds.

[0076] 2. Preliminary curing of suppositories

[0077] Cool the mold to 41°C for 10 minutes

[0078] 3. Insertion of radioactive particles

[0079] With embodiment 1.

[0080] 4. Complete curing of suppositories

[0081] Cool the mold to room temperature. Take it out, demould it, pack it and store it in a refrigerator to form a suppository product carrying radioactive particles.

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Abstract

The invention belongs to the technical field of pharmaceutical preparations, and relates to a suppository carrying radioactive particles and a preparation method of the suppository. Each suppository is prepared from the following raw materials: one to six radioactive particles and 0.02-0.5 g of a gelatinizing substance. By means of the suppository carrying the radioactive particles and the preparation method of the suppository, the suppository carrying the radioactive particles can be better prepared; and the prepared suppository carrying the radioactive particles is applicable to radioactiveclose-range treatment of tumors near the cavity and in the lumen, thereby achieving the dual purposes of radioactive treatment and drug treatment.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and relates to a suppository carrying radioactive particles and a preparation method thereof. Background technique [0002] Malignant tumors have always been a major disease that threatens human health, and interstitial brachytherapy of tumors using radioactive particles is a new technology developed in recent decades. In tumor brachytherapy, radioactive particles are directly implanted into the lesion, and the short-distance continuous irradiation destroys the DNA double bond of the tumor cell nucleus, causing death or sub-lethal tumor cells, making them lose their ability to replicate, so as to achieve the purpose of treatment. At the same time, the energy of isotope rays used in tumor brachytherapy is low, which can effectively prevent the rays from damaging normal tissues during irradiation. [0003] The radioactive particle source is a small radioactive source. The radio...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K51/12A61K51/06A61K45/06A61K9/02A61K47/36A61P35/00
CPCA61K51/1203A61K51/06A61K45/06A61K9/02A61K47/36A61P35/00
Inventor 张文辉高惠波李忠勇
Owner HTA CO LTD
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