Preparation method of functional nanoparticle doped polymer antibacterial fiber membrane

Abstract

The invention discloses a preparation method of a functional nanoparticle doped polymer antibacterial fiber membrane for photodynamic and photothermodynamic collaborative treatment. The method comprises the following steps of S1, synthesis of upconversion nanoparticles; S2, synthesis of titanium dioxide loaded upconversion nanoparticles; S3, synthesis of titanium dioxide and graphene oxide loadedupconversion nanoparticles; and S4, preparation of the composite nanoparticle loaded polyvinylidene fluoride composite fiber membrane. The method has the advantages that a single NIR light source canbe used to realize the efficient sterilization effect of photodynamic and photothermodynamic collaboration at the same time, an action system is enabled to be simple, convenient and effective, and thecomposite membrane has good cell compatibility, can realize repeated sterilization, does not cause harm to organisms, does not cause the drug resistance of the organisms, and has the relatively obvious antibacterial activity for Gram-negative bacteria and Gram-positive bacteria.

Description

technical field [0001] The invention belongs to the field of biopolymer materials, and relates to a polymer antibacterial fiber film doped with functional nanoparticles for photodynamic and photothermodynamic synergistic treatment and a preparation method thereof. Background technique [0002] Infections caused by pathogenic bacterial strains, particularly multidrug-resistant strains, during wound healing in patients are a growing concern for the increasing mortality of patients. In the process of wound treatment, the development and application of antibacterial materials that are effective, have little side effects on the human body, and are not easy to cause bacterial drug resistance are of great significance. [0003] The strategy of photodynamic therapy is to combine appropriate excitation light, photosensitizer and oxygen, and then generate cytotoxic reactive oxygen species to attack microorganisms non-specifically, thereby causing the microorganisms to lyse and die. S...

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Problems solved by technology

[0005] A single photodynamic therapy is generally difficult to achieve high-efficiency antibacterial effects, so the design of a system based on NIR-excited photodynamics and other therapeutic methods has attracted widespread attention (Yu Z, Sun Q, Pan W, LiN ,Tang B.A Near-Infrared Triggered Nanophotosensitizer Inducing Domino Effecton Mito-chondrial Reactive Oxygen Species Burst for Cancer Therapy.ACS Nano2015,9:11064-11074)

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