Device and method for handheld oral angiography based on swept-frequency optical coherence tomography

Abstract

The invention discloses a handheld human oral cavity swept-frequency optical coherence tomography structure and angiography device. The device comprises a high-speed swept-frequency laser light source, a circulator, a 2*2 optical fiber coupler, a first polarization controller, a first collimating lens, a first converging lens, a plane mirror, a second polarization controller, a second collimatinglens, a scanning galvanometer, a first lens, a second lens, a second converging lens, a rectangular prism, a photoelectric balance detector, a data acquisition card, a signal processing system, a signal generation card and a handheld sample arm mechanical structure, wherein the second collimating lens, the scanning galvanometer, the first lens, the second lens, the second converging lens and the rectangular prism form a light path part of a sample arm; and the light path part of the sample arm is placed on the handheld sample arm mechanical structure. The device is non-invasive, high in imaging speed and high in resolution, the handheld sample arm can image any position of the oral cavity, and the device is of great significance in clinical diagnosis of various oral diseases such as oral cancer.

Description

technical field [0001] The invention relates to the field of optical coherence tomography (Optical Coherence Tomography, OCT) technology research, in particular to a hand-held oral angiography device and method based on frequency-sweeping optical coherence tomography. Background technique [0002] Oral cancer has become a serious health problem worldwide. From the perspective of oral cancer pathogenesis, approximately 95% of oral cancers are squamous cell carcinomas (SCC) with a long preclinical stage consisting of numerous premalignant lesions that will undergo hyperplasia, dysplasia, and carcinoma in situ (CIS) to the sequential course of invasive SCC. However, up to 50% of oral cancers are not detected until late stage, so effective diagnostic tools are needed for early screening and diagnosis of oral cancer. [0003] Traditional visual inspection, tactile assessment, and invasive biopsy are commonly used screening methods to detect oral diseases, but due to limited vis...

AI Technical Summary

Problems solved by technology

Based on the above imaging methods, the detectable resolution of the mucosal surface can be improved, but the penetration depth is limited to hundreds of microns, and it cannot reach deeper structures that can obtain valuable information (such as where the disease occurs and how it will develop), which is not conducive to Find abnormal cells in precancerous or malignant stages

In addition, when using confocal microscopy for microvascular imaging, exogenous fluorescent dyes need to be used, which are harmful to the human body and may cause allergies and even death

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