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Probiotic toothpaste with function of oral helicobacter pylori resistance and preparation method thereof

A technology of Helicobacter pylori and probiotics, applied in antibacterial drugs, oral care, resistance to vector-borne diseases, etc., can solve problems such as increasing the drug resistance of Helicobacter pylori, reduce adhesion and aggregation, prevent dental caries, and kill The effect of cariogenic bacteria

Active Publication Date: 2020-05-01
JIANGSU WECARE BIOTECHNOLOGY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The technical problem to be solved by the present invention is to provide a probiotic toothpaste against oral Helicobacter pylori and its preparation method, which solves the problem that the existing methods of killing Helicobacter pylori tend to increase the drug resistance of Helicobacter pylori

Method used

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  • Probiotic toothpaste with function of oral helicobacter pylori resistance and preparation method thereof
  • Probiotic toothpaste with function of oral helicobacter pylori resistance and preparation method thereof
  • Probiotic toothpaste with function of oral helicobacter pylori resistance and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Take compound probiotics (Lactobacillus gasseri: Lactobacillus salivarius: Lactobacillus paracasei is 3:1:1) 1.0 kg, lactoferrin 0.5 kg, ε-polylysine 0.1 kg, polyethylene glycol 4 kg , 10 kilograms of glycerin, 3 kilograms of sodium lauryl sulfate, 2 kilograms of carboxymethyl cellulose, 1 kilogram of hydroxyethyl cellulose, 12 kilograms of sorbitol, 15 kilograms of silicon dioxide, 0.3 kilograms of sodium saccharin, deionized water to 100 kg, fully stirred, homogenized with a homogenizer, and then filled with vacuum to prepare a probiotic toothpaste against oral Helicobacter pylori.

[0018] The code of the above-mentioned Lactobacillus gasseri preservation unit: CGMCC-General Microbiology Center of China Microbial Culture Collection Management Committee; Address: No. 3, No. 1, Beichen West Road, Chaoyang District, Beijing; the detection results of the Lactobacillus gasseri are: survival; preservation Date: July 18, 2018; Deposit number: CGMCC No.16131; Classification ...

Embodiment 2

[0034] Take compound probiotics (Lactobacillus gasseri: Lactobacillus salivarius: Lactobacillus paracasei is 2:2:1) 1.0 kilograms, lactoferrin 2 kilograms, ε-polylysine 0.2 kilograms, polyethylene glycol 6 kilograms , 8 kg of glycerin, 2 kg of sodium lauryl sulfate, 2 kg of carboxymethyl cellulose, 1 kg of hydroxyethyl cellulose, 10 kg of sorbitol, 12 kg of silicon dioxide, 0.3 kg of sodium saccharin, deionized water to 100 kg, fully stirred, homogenized with a homogenizer, and then filled with vacuum to prepare a probiotic toothpaste against oral Helicobacter pylori. The same as Example 1, there are 400 experimental cases, and the population has been used for three consecutive months, and the oral HP has turned negative by more than 80%, and there is no cariogenic bacteria.

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Abstract

The invention discloses probiotic toothpaste with a function of oral helicobacter pylori resistance and a preparation method thereof and relates to the technical field of probiotic toothpaste. The probiotic toothpaste is prepared from the following raw materials in parts by weight: 1-15 parts of sorbitol, 1-8 parts of glycerinum, 1-20 parts of silicon dioxide, 0.1-10 parts of polyethylene glycol,0.1-3 parts of lauryl sodium sulfate, 0-5 parts of lactoferrin, 0.1-3 parts of carboxymethyl cellulose, 0-3 parts of probiotic complex, 0-3 parts of saccharin sodium salt, 0.1-3 parts of hydroxyethylcellulose, 0-3 parts of epsilon-polylysine and deionized water which is added until total amount is 100 parts. The probiotic toothpaste with the function of oral helicobacter pylori resistance is prepared by mixing probiotics with a bacteriostatic function with lactoferrin and epsilon-polylysine and auxiliary raw materials including glycerinum, carboxymethyl cellulose and sorbitol, and has the effects of quickly killing harmful bacteria, such as oral helicobacter pylori, cariogenic bacteria and the like.

Description

technical field [0001] The invention relates to the technical field of probiotic toothpaste, in particular to a probiotic toothpaste against oral Helicobacter pylori and a preparation method thereof. Background technique [0002] Helicobacter pylori is a gram-negative bacterium that lives in various areas of the mouth, stomach and duodenum, and Helicobacter pylori is also an infectious bacterium that passes through mouth-to-mouth, mouth-to-stomach in the population phase spread; Helicobacter pylori will produce a thin layer of bacterial film on the tooth surface within 2 hours after entering the oral cavity, and gradually form dental plaque, which will be colonized in the teeth and oral cavity. Zhoubao will continue to produce stubborn bad breath, and more seriously, it will continue to be transmitted to the stomach through the digestive tract, causing chronic gastritis, gastric ulcers, and even gastric cancer. Data show that every 2 adults, there is 1 Helicobacter pylori i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/99A61K8/64A61K8/73A61K8/88A61K8/34A61Q11/00A61P31/04
CPCA61K8/99A61K8/88A61K8/64A61K8/345A61K8/731A61Q11/00A61P31/04Y02A50/30
Inventor 方曙光朱加军于惠陈珂可朱建国
Owner JIANGSU WECARE BIOTECHNOLOGY CO LTD
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