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Broad spectrum type antimicrobial peptide (AMP) and application thereof

An antimicrobial peptide and broad-spectrum technology, applied in the field of medicine, can solve problems such as endangering food safety and public health safety, bacterial drug resistance makes the prevention and control of human and animal diseases more difficult, and achieves good application prospects and is not easy to drug resistance sexual effect

Active Publication Date: 2020-05-01
HARBIN VETERINARY RES INST CHINESE ACADEMY OF AGRI SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, serious bacterial resistance has increased the difficulty of preventing and controlling human and animal diseases, and has become a major problem that endangers modern breeding industry, food safety and public health safety.

Method used

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  • Broad spectrum type antimicrobial peptide (AMP) and application thereof
  • Broad spectrum type antimicrobial peptide (AMP) and application thereof
  • Broad spectrum type antimicrobial peptide (AMP) and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Antibacterial activity research of embodiment 1 polypeptide 26M

[0024] 1 Materials and methods

[0025] 1.1 Materials:

[0026] 1.1.1 Strains

[0027] Escherichia coli ATCC 25922, Salmonella ATCC 51741, Pseudomonas aeruginosa ATCC 27853, Acinetobacter baumannii ATCC 19606, Klebsiella pneumoniae ATCC 700603, Streptococcus suis ATCC 43765, Staphylococcus aureus ATCC29213, armor resistance Staphylococcus aureus ATCC 33591 and vancomycin-resistant Enterococcus faecium ATCC 700221 were purchased from the American Type Culture Collection.

[0028] 1.1.2 Drugs and reagents

[0029] Tryptical soy broth (TSB) and tryptical soy agar (TSA) were purchased from BD Company, USA, 10 mM phosphate buffer saline (Phosphate Buffer Saline, PBS), trifluoroethanol (Trifluoroethanol, TFE) was purchased from Sigma Company of the United States, and 30mM SDS was purchased from Amresco Company of the United States.

[0030] 1.1.3 Instruments

[0031] The analytical balance was purchased f...

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Abstract

The invention discloses a broad spectrum type antimicrobial peptide (AMP) and application thereof and belongs to the technical field of medicine. The AMP is named 26 M, contains 18 amino acid residues, has a molecular weight of 2475.16 Daltons, has an isoelectric point of 12.03, and has an amino acid sequence shown in SEQ ID NO: 1. Experiments show that the AMP has the effect of significantly inhibiting the growth and reproduction of various pathogenic bacteria including Escherichia coli, Salmonella, Pseudomonas aeruginosa, Acinetobacter baumannii, Klebsiella pneumoniae, Streptococcus suis, Staphylococcus aureus, methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus faecium. The invention provides the novel AMP with a broad-spectrum antimicrobial effect,and the AMP can replace traditional antibiotics and cannot produce drug resistance easily, and has good application prospects in resisting infectious diseases caused by pathogenic bacteria.

Description

technical field [0001] The invention relates to an antibacterial peptide and its application, in particular to an antibacterial peptide with broad-spectrum antibacterial effect and its application. The invention belongs to the technical field of medicine. Background technique [0002] With the abuse of traditional antibiotics, the cycle of bacterial resistance to antibiotics has been continuously shortened, resulting in the proliferation of multi-drug resistant bacteria in recent years. Due to the accelerating rate of bacterial resistance and mutation, the development of new antibiotics is very slow. At present, serious bacterial resistance has increased the difficulty of preventing and controlling human and animal diseases, and has become a major problem that endangers modern aquaculture, food safety and public health safety. In 2006, the European Union began to completely ban the use of antibiotic growth promoters, and my country also issued a feed "antibiotic ban" order...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K14/52C12N15/19A61K38/19A61P31/04
CPCA61K38/00A61P31/04C07K14/521
Inventor 谢芳刘思国张万江张跃灵
Owner HARBIN VETERINARY RES INST CHINESE ACADEMY OF AGRI SCI
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