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Polyvinyl alcohol/carboxymethyl chitosan nanofiber medical dressing as well as preparation method and application thereof

A technology of carboxymethyl chitosan and polyvinyl alcohol, applied in the field of medicine, can solve the problems of easy drying of wounds, crusting of exudates, bacterial growth, etc., and achieve good absorption of skin exudates, good air permeability, high The effect of porosity

Active Publication Date: 2020-05-08
东莞华工创为生物科技有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, most medical institutions in my country still use traditional cotton gauze as a commonly used medical dressing, but traditional medical gauze needs to be replaced frequently, and the wound is easy to dry. The adhesion between the new tissue will cause secondary trauma to the new tissue, and there will also be clinical phenomena such as bacterial growth and poor hemostasis effect.

Method used

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  • Polyvinyl alcohol/carboxymethyl chitosan nanofiber medical dressing as well as preparation method and application thereof
  • Polyvinyl alcohol/carboxymethyl chitosan nanofiber medical dressing as well as preparation method and application thereof
  • Polyvinyl alcohol/carboxymethyl chitosan nanofiber medical dressing as well as preparation method and application thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] The experiment was carried out under the environment temperature of 30° C. and humidity of 40% RH. Take by weighing the PVA of 10g with electronic balance, it is packed in the clean Erlenmeyer flask, then 1.5g (known solid content is 30%) of Periplaneta americana concentrated solution is added in the Erlenmeyer flask, adds 2g in the volumetric flask CMCS, after calculating the mass ratio of solute and solvent, add 100g of pure water into the Erlenmeyer flask, stir in a water bath at a temperature of 60°C for 5 hours, and prepare the Periplaneta americana @PVA / CMCS spinning solution. The spinning conditions were set as follows: injection speed 4.0mm / h, receiving distance 20cm, spinning voltage 23kV, using electrospinning machine to prepare Periplaneta americana @PVA / CMCS nanofiber membrane medical dressing. Set the drying temperature at 85°C, dry in an oven for 30 minutes, and undergo a certain heat treatment to promote the crosslinking reaction and improve the water res...

Embodiment 2

[0035] The experiment was carried out under the condition that the ambient temperature was 25° C. and the humidity was 42% RH. Take by weighing the PVA of 5g with electronic balance, it is packed in the clean Erlenmeyer flask, then 0.8g (known solid content is 30%) of Periplaneta americana concentrated solution is added in the Erlenmeyer flask, adds 2g in the volumetric flask CMCS, after calculating the mass ratio of solute and solvent, add 45g of pure water into the Erlenmeyer flask, stir in a water bath at a temperature of 60°C for 5 hours, and prepare the Periplaneta americana @PVA / CMCS spinning solution. The spinning conditions were set as follows: injection speed 3.0mm / h, receiving distance 18cm, spinning voltage 20kV, using electrospinning machine to prepare Periplaneta americana @PVA / CMCS nanofiber membrane medical dressing. Set the drying temperature at 90°C, and dry in an oven for 60 minutes. After a certain heat treatment, the cross-linking reaction is promoted, and ...

Embodiment 3

[0038] The experiment was carried out under the environment temperature of 25° C. and humidity of 39% RH. Take by weighing the PVA of 5g with electronic balance, it is packed in the clean Erlenmeyer flask, then 0.7g (known solid content is 30%) of Periplaneta americana concentrated solution is added in the Erlenmeyer flask, adds 1.5 to the volumetric flask g CMCS. After calculating the mass ratio of solute to solvent, add 40g of pure water into the Erlenmeyer flask, stir in a water bath at a temperature of 60°C for 5 hours, and prepare the Periplaneta americana @PVA / CMCS spinning solution. The spinning conditions were set as follows: injection speed 5.0mm / h, receiving distance 20cm, spinning voltage 21kV, using electrospinning machine to prepare Periplaneta americana @PVA / CMCS nanofiber membrane medical dressing. Set the drying temperature at 80°C, and dry in an oven for 90 minutes. After a certain heat treatment, the cross-linking reaction is promoted, and the water resistance...

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Abstract

The invention belongs to the technical field of medicines, and particularly discloses a polyvinyl alcohol / carboxymethyl chitosan nanofiber medical dressing as well as a preparation method and an application thereof. The preparation method specifically comprises the following steps of uniformly mixing polyvinyl alcohol (PVA), carboxymethyl chitosan (CMCS), periplaneta americana concentrate and water to prepare a spinning solution containing periplaneta americana active substances; and then carrying out electrostatic spinning to prepare a periplaneta americana sustained-release medical dressing.Compared with a traditional medical gauze dressing or a medical dressing prepared by using a coating method, the sustained-release nanofiber medical dressing has quite high air permeability and highporosity, so that a wound can be kept moist, and the breathing effect of cells is facilitated. The nanofibers are effective to prevent bacteria and particulates in the air from contacting the wound. Compared with the conventional medical dressing prepared by coating, the nanofiber medical dressing has high air permeability and relatively high absorption of skin exudate.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a polyvinyl alcohol / carboxymethyl chitosan nanofiber medical dressing and a preparation method and application thereof. Background technique [0002] Periplaneta americana belongs to the genus Periplaneta, commonly known as cockroach, is one of the insect groups with the strongest vitality, the oldest and the most successful reproduction so far in the world. Periplaneta americana is a traditional Chinese medicinal material that was first recorded in "Shen Nong's Materia Medica". Modern research has shown that it has pharmacological effects such as anti-cancer, anti-bacterial, anti-inflammatory, and promotion of tissue repair. The chemical components in Periplaneta americana mainly include pheromones, aggregation pheromones, amino acids, neuropeptides, sugars, proteins, oils, nucleic acids, isoflavones, etc. [0003] Carboxymethyl chitosan and its various derivatives...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): D04H1/4326D04H1/728D01F6/50D01F1/10D01D5/00A61F13/00
CPCD04H1/4326D04H1/728D01D5/003D01D5/0092A61F13/00987A61F13/00063D01F6/50D01F1/103A61F2013/00906A61F13/01012
Inventor 程建华黄政张继勇
Owner 东莞华工创为生物科技有限公司
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