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Collagen-sodium humate compound suitable for hemostatic material and preparation method thereof

A technology of sodium humate and hemostatic material, which is used in drug delivery, pharmaceutical formulations, bandages, etc., can solve the problems of chitosan having no biological activity, high price of alginic acid dressing, and no self-adhesiveness, etc., to improve stability. and mechanical properties, improve hemostatic properties, high value-added effects

Active Publication Date: 2022-05-10
SHAANXI UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, chitosan has no biological activity and poor processability; alginic acid dressings are expensive and most products are not self-adhesive

Method used

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  • Collagen-sodium humate compound suitable for hemostatic material and preparation method thereof
  • Collagen-sodium humate compound suitable for hemostatic material and preparation method thereof

Examples

Experimental program
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preparation example Construction

[0030] The invention discloses a preparation method of a collagen-sodium humate compound suitable for hemostatic materials, which specifically includes the following steps:

[0031] (1) Take 1-10 parts of collagen sponge and dissolve it in saline solution to prepare a collagen solution with a concentration of 0.1%-1.5%; the salt content in the saline solution is controlled at 80-200mmol / L; the temperature is controlled below 10 °C;

[0032] (2) Take 0.25 to 40 parts of sodium humate and dissolve it in a salt solution at room temperature to prepare a sodium humate solution with a concentration of 0.025% to 6%; the salt content in the salt solution is controlled at 80 to 200mmol / L;

[0033] (3) Slowly add 0.025% ~ 6% sodium humate solution dropwise to the stirring collagen solution, the ratio of sodium humate to collagen dry weight is 1:0.05 ~ 20; the temperature is controlled below 10 °C, and the pH value is controlled At 4~9, stir for 6~24h to prepare the collagen-sodium humat...

Embodiment 1

[0039] Take 1 part of collagen sponge, dissolve it in 100 parts of 120mmol / L sodium chloride solution at 4°C to prepare a collagen solution with a concentration of 1%, and adjust the pH to 7.0 with sodium hydroxide. Get 1 part of sodium humate, dissolve it in 100 parts of 120mmol / L sodium chloride solution at normal temperature to prepare a sodium humate solution with a concentration of 1%, adjust the pH to 7.0 with sodium hydroxide; The sodium solution was slowly added dropwise to the stirring collagen solution, the ratio of sodium humate to collagen dry weight was 1:1, and the collagen-sodium humate composite solution was obtained by stirring for 12 hours; subsequently, the composite solution was placed at 37°C for self- Assembly to prepare composite hydrogels.

[0040] figure 1 It is the electrophoretic pattern of the collagen-sodium humate composite material in Example 1. Among them, the electrophoretic bands of collagen and collagen-sodium humate composite materials are...

Embodiment 2

[0042] Take 1 part of collagen sponge and dissolve it in 125 parts containing 10mmol / L disodium hydrogen phosphate / sodium dihydrogen phosphate and 100mmol / L sodium chloride at 10°C to prepare a 1% collagen solution with a pH value of about 7.4. Take 1.5 parts of sodium humate and dissolve it in a solution containing 10mmol / L disodium hydrogen phosphate / sodium dihydrogen phosphate and 100mmol / L sodium chloride at room temperature to prepare a 1.5% sodium humate solution with a pH value of about 7.4 ; Slowly add sodium humate solution dropwise to the stirring collagen solution at 10°C, the ratio of sodium humate to collagen dry weight is 6:4, and stir for 20 hours to obtain a collagen-sodium humate composite solution; subsequently, compound The solution was placed at 35°C for self-assembly to prepare composite hydrogels.

[0043] figure 2 It is the thermal stability test result of the collagen-sodium humate composite material in Example 2, which shows that the thermal stability...

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Abstract

The invention discloses a collagen-sodium humate compound suitable for hemostatic materials and a preparation method thereof. The invention uses natural collagen with good biological activity and natural polymer sodium humate with hemostatic and wound healing effects as main raw materials, and prepares a composite solution with good compatibility under low temperature conditions by means of the charge shielding effect of salt. The composite hydrogel was prepared by self-assembly, and the collagen-sodium humate complex was obtained by freeze-drying. The prepared composite hydrogel and sponge improved the thermal stability, hemostasis, and promotion of platelet aggregation of single collagen hydrogel, and the hydrogel and sponge had the advantages of good porosity, hydrophilicity, antibacterial and anti-inflammatory properties, etc. . The hydrogel and sponge can be used alone or in combination with other materials for hemostatic dressings.

Description

technical field [0001] The invention belongs to the technical field of collagen-based medical materials, and in particular relates to a collagen-sodium humate compound suitable for hemostatic materials and a preparation method thereof. Background technique [0002] A dressing is a biomedical material used to treat skin lesions. The traditional gauze dressing only plays the role of covering the wound, does not promote the healing of the wound and is easy to adhere to the wound, resulting in damage to the wound when changing the dressing. Subsequently, various new types of modern dressings emerged. Most of these dressings can adhere well to the wound surface, play a part of the role of skin barrier, and provide a favorable microenvironment for wound healing, but they do not adhere to the wound surface to avoid dressing replacement. Bring secondary damage; at the same time, it has important functions such as anti-inflammatory, hemostasis, and accelerated wound healing. But cu...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J9/28C08L89/00C08L97/00A61L15/22A61L15/42A61L15/44A61L15/46
CPCC08J9/28A61L15/225A61L15/42A61L15/425A61L15/44A61L15/46A61L2400/04A61L2300/404A61L2300/41C08J2389/00C08J2397/00C08J2489/00C08J2497/00C08J2201/0484C08L89/00C08L97/00
Inventor 田振华王颖何静瑄张康马建中吕斌
Owner SHAANXI UNIV OF SCI & TECH
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