New application of laxative formula using five fruits and vegetables as raw materials and being capable of increasing intestinal mucus layer and protecting intestinal tract

A new application, intestinal technology, applied in the direction of plant raw materials, medical raw materials derived from fungi, medical preparations containing active ingredients, etc., can solve problems such as unsuitable constipation, severe constipation, and damage to the bacterial flora structure

Pending Publication Date: 2020-05-29
HEBEI YUZHILIN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These cathartics act like high-pressure water guns in our intestines. Although they can take away the stool, they will also take away the probiotics in the intestines and destroy the flora structure in the intestines. Once they are stopped, constipation will occur. It is more serious, and long-term use will cause more intestinal diseases
[0051] 3. Products based on traditional Chinese medicine are not suitable for all types of constipation due to the limitations of the population using Chinese medicinal materials

Method used

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  • New application of laxative formula using five fruits and vegetables as raw materials and being capable of increasing intestinal mucus layer and protecting intestinal tract
  • New application of laxative formula using five fruits and vegetables as raw materials and being capable of increasing intestinal mucus layer and protecting intestinal tract
  • New application of laxative formula using five fruits and vegetables as raw materials and being capable of increasing intestinal mucus layer and protecting intestinal tract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0063] Embodiment 1 Goblet cell proliferation pharmacological experiment

[0064] 1. Grouping, feeding and administration of rats

[0065] The SD rats were adaptively fed for 1 week, weighed, and randomly distributed into 5 groups (n=10) according to body weight. The model group and the treatment group were given loperamide (LOP) by subcutaneous injection for 2 weeks to induce the rat constipation model; from the second week onwards, the positive drug Maren Capsule (MRC) and Modification Capsules (TTC), for 1 week. TTC and MRC were suspended in 0.3% sodium carboxymethylcellulose (CMC-Na) solution. The specific modeling and treatment methods are as follows:

[0066] Group 1: normal group (NC), subcutaneous injection of normal saline (10ml / kg), given 0.3% CMC-Na (10mL / kg / d).

[0067] Group 2: model group (CP), LOP (10ml / kg), given 0.3% CMC-Na (10mL / kg / d).

[0068] Group 3: Positive drug group (MRC), subcutaneous injection of LOP (10ml / kg), given MRC (126mg / kg / d).

[0069] ...

Embodiment 2

[0074] Embodiment 2 mucus layer pharmacological experiment

[0075] Methods for the detection of colonic mucus

[0076] Tissue samples: After 3 weeks of the experiment, the rats were fasted for 12 hours, weighed, and then anesthetized with 10% chloral hydrate (0.3mL / 100g), and the colon tissues were immediately removed, fixed in 10% buffered formalin for 48 hours and wrapped Embedded in paraffin, cut into 5 μm thick sections and stained with Alcian blue to assess the thickness of the colonic mucus layer.

[0077] Colonic mucus test results

[0078] The study found that the adherent rectal mucus layer was significantly reduced in patients with chronic constipation. The use of lubiprostone can increase the secretion of mucus and mucin. Therefore, constipation may be related to the secretion of mucus and mucin. In this experiment, in order to verify the correlation between constipation and mucus, we detected the thickness of the mucus layer in the colon tissue ( figure 2 )....

Embodiment 3

[0079] Embodiment 3 clinical trial 1

[0080] Gastric ulcer is a common digestive system disease in clinical practice, and the main patients are mostly the elderly. The clinical symptoms in the early stage are not obvious. When the gastric ulcer is severe, the main symptom is perforation or bleeding. If you do not seek medical treatment in time, it will seriously affect your daily life and quality of life, and eventually lead to the appearance of cancer. Our company analyzed and summarized the clinical data of 89 patients with gastric ulcer from May 2018 to October 2018. The report is as follows:

[0081] 1. Patient information: 62 males and 27 females, aged 40-65 years, average age (53.6±2.8) years; body weight 44-75kg, average (57.3±3.8) kg; course of disease 0.5-15 years. The main clinical manifestations are stomach pain with a sense of bloating, loss of appetite, and lack of energy. Nausea, nausea, vomiting, acid reflux, belching, poor daily bowel movements, melena and o...

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Abstract

The invention discloses new application of a laxative formula using five fruits and vegetables as raw materials, and provides application of the laxative formula using five fruits and vegetables as raw materials in preparation of food or drugs for increasing the intestinal mucus layer and protecting intestinal tract; the laxative formula can be Biantong Tiantian capsules which consist of pumpkins,aloes, poria cocos, tremella and xylo-oligosaccharide with the thickness being 5 micrometers to 20 micrometers. A research proves that the Biantong Tiantian capsules can increase the quantity of caliciform cells of constipated rats, and can increase the thickness of a mucous layer. A new means is provided for increasing the intestinal mucus layer, protecting the intestinal tract and improving symptoms of gastric ulcer, and the new application has wide clinical application prospects.

Description

technical field [0001] The invention relates to a laxative prescription and its new application, belonging to the field of traditional Chinese medicine. Background technique [0002] 1. Gastric mucosa [0003] As an important digestive organ of the human body, the stomach will directly affect human health if there is a problem. Therefore, people with a bad stomach should not do these 4 things, especially the first one, which will damage the gastric mucosa very much. The main reasons for a bad stomach are: irregular diet, often staying up late, often eating spicy and stimulating food. These bad habits damage the gastric mucosa and increase gastric acid, so that the gastric acid corrodes the gastric wall for a long time. At this time, inflammation and ulcers will gradually appear on the gastric wall, which will lead to more serious gastric diseases. [0004] The gastric mucosa is composed of three parts: epithelium, lamina propria and muscularis mucosae. There are many sha...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/896A61K36/886A61K9/48A61P1/00A23L33/10A61K31/702
CPCA61K36/42A61K36/896A61K36/886A61K36/076A61K36/07A61K31/702A61K9/48A61P1/00A23L33/10A23V2002/00A61K2300/00A23V2200/32
Inventor 朱志铭赵大鹏张赞李积珍
Owner HEBEI YUZHILIN PHARMA
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