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In-situ glue forming hydrogel as well as preparation method and application thereof

An in-situ, glue technology, applied in applications, pharmaceutical formulations, medical science and other directions, can solve the problem of lack of hemostatic materials, etc., and achieve the effects of excellent biocompatibility, slow blood flow rate, and reasonable gel formation time.

Active Publication Date: 2020-05-29
XI AN JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, there is currently no hemostatic material that can meet the above requirements

Method used

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  • In-situ glue forming hydrogel as well as preparation method and application thereof
  • In-situ glue forming hydrogel as well as preparation method and application thereof
  • In-situ glue forming hydrogel as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] In terms of mass percentage, dimethylaminopropyl acrylamide (DMAPAA) 1-10%, (3-acrylamidopropyl) trimethyl ammonium chloride (AATAC) 10-20% and 2-methacryloyl Add 1-3% of oxyethylphosphorylcholine (MPC) into deionized water, add a small amount of APS (0.5%-2%) to the mixed system, shake gently for a few seconds, and quickly form a gel.

[0031] Example 1

[0032] In terms of mass percentage, dimethylaminopropyl acrylamide (DMAPAA) 5%, (3-acrylamidopropyl) trimethylammonium chloride (AATAC) 15% and 2-methacryloyloxyethyl phosphoric acid Add 2% choline (MPC) into deionized water, add a small amount of APS (1%) to the mixed system, shake gently for a few seconds and quickly form a gel.

Embodiment 2

[0034] In terms of mass percentage, dimethylaminopropyl acrylamide (DMAPAA) 1%, (3-acrylamidopropyl) trimethyl ammonium chloride (AATAC) 10% and 2-methacryloyloxyethyl phosphoric acid Choline (MPC) 1% was added to deionized water, a small amount of APS (0.5%) was added to the mixed system, and after a few seconds of gentle shaking, the gel was formed quickly.

Embodiment 3

[0036] In terms of mass percentage, dimethylaminopropyl acrylamide (DMAPAA) 8%, (3-acrylamidopropyl) trimethyl ammonium chloride (AATAC) 20% and 2-methacryloyloxyethyl phosphoric acid Add 2% choline (MPC) into deionized water, add a small amount of APS (1%) to the mixed system, shake gently for a few seconds and quickly form a gel.

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PUM

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Abstract

The invention discloses in-situ glue forming hydrogel as well as a preparation method and application thereof. According to the in-situ gel forming hydrogel, dimethylaminopropyl acrylamide, (3-acrylamidopropyl)trimethyl ammonium chloride and 2-methacryloyloxyethyl choline phosphate are initiated by an initiator by utilizing free radical polymerization to quickly generate gel in situ, and the gel forming time is short, so that the effects of sealing and stopping bleeding are achieved. During preparation of the in-situ gelling hydrogel, the ratio of the raw materials can be accurately controlled, no cross-linking agent is used, reasonable gelling time can be achieved, the gelling time is shorter than 10 s, and meanwhile, the gel has high viscoelasticity and self-healing performance and can better meet the requirements of surgical operations.

Description

technical field [0001] The invention belongs to the technical field of biogel materials, and relates to an in-situ glue-forming hydrogel and a preparation method and application thereof. Background technique [0002] In surgical operations, rapid, effective and safe hemostasis is one of the key factors to ensure the success of the operation. How to quickly stop bleeding is an important problem in trauma and surgery. Excessive bleeding will destroy hemodynamics, prolong operation time, and require blood transfusion. Pressing to stop bleeding is the most common and easiest way to stop bleeding, but it is not effective for large, deep and irregular wounds. Hemocompatibility is a very important consideration when using biomaterials for hemostasis. Synthetic hemostats, often made from cyanoacrylates, polyurethanes, and polyethylene glycols, can lead to polymerization and degradation of toxic by-products, solvents, and necrotic tissue that can increase local irritation and infla...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/075C08F220/60C08F230/02A61L24/00
CPCA61L24/00A61L24/001A61L24/0015A61L24/0031A61L2300/404A61L2400/04C08F220/60C08J3/075C08J2333/24C08F230/02
Inventor 王珂高居山赵晓曄
Owner XI AN JIAOTONG UNIV
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