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Preparation method of cadmium telluride quantum dot doped hydroxyapatite fluorescent probe

A technology of cadmium telluride quantum dots and hydroxyapatite, which is applied in chemical instruments and methods, fluorescence/phosphorescence, measuring devices, etc., can solve the problems of obvious pH value changes, difficult storage, and difficult separation of semiconductor quantum dots.

Inactive Publication Date: 2020-06-02
启东润博园区管理服务有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although quantum dots have many advantages, their practical application as a fluorescent probe is subject to many limitations, such as obvious changes in fluorescence characteristics with temperature and pH value and difficulty in storage. The main limitation is the separation and recovery of quantum dots after detection. Because the semiconductor quantum dots are too small and difficult to separate, the residual quantum dots will cause secondary pollution

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] A method for preparing a cadmium telluride quantum dot-doped hydroxyapatite fluorescent probe, comprising the following steps: configuring 55 parts with a concentration of 3.8×10 -3 mol / L cadmium acetate solution, adjust its pH value to 11.0 with NaOH solution with a concentration of 1mol / L, stir for 15 minutes, add 0.2 parts of thioglycolic acid, keep the pH value constant, continue stirring for 15 minutes, add 60 parts of thioglycolic acid with a concentration of 8.2 ×10 - 4 mol / L potassium tellurite solution and 10 parts of sodium borohydride, keep the pH value constant, stir for 15 minutes, reflux the reaction system at 110°C for 30 minutes to obtain the CdTe quantum dot precursor suspension, and store it at 4°C; The concentration of 85 parts is 4.6×10 -2 mol / L CaCl 2 Solution, with a concentration of 1mol / L NaOH solution to adjust its pH value to 10.2, heated in a water bath at 65°C with continuous stirring, and added 85 parts with a concentration of 2.8×10 -2 ...

Embodiment 2

[0019] A method for preparing a cadmium telluride quantum dot-doped hydroxyapatite fluorescent probe, comprising the following steps: configuring 50 parts with a concentration of 3.8×10 -3 mol / L cadmium acetate solution, adjust its pH value to 10.8 with NaOH solution with a concentration of 1mol / L, stir for 10 minutes, add 0.1 parts of thioglycolic acid, keep the pH value constant, continue stirring for 10 minutes, add 55 parts of thioglycolic acid with a concentration of 8.2 ×10 - 4 mol / L potassium tellurite solution and 8 parts of sodium borohydride, keep the pH value unchanged, stir for 10 minutes, reflux the reaction system at 105°C for 25 minutes to obtain the CdTe quantum dot precursor suspension, and store it at 4°C; The concentration of 80 parts is 4.6×10 -2 mol / L CaCl 2 Solution, with a concentration of 1mol / L NaOH solution to adjust its pH value to 10.1, heated in a water bath at 64°C with continuous stirring, and added 80 parts dropwise with a concentration of 2....

Embodiment 3

[0021] A method for preparing a cadmium telluride quantum dot-doped hydroxyapatite fluorescent probe, comprising the following steps: configuring 60 parts with a concentration of 3.8×10 -3 mol / L cadmium acetate solution, adjust its pH value to 11.2 with NaOH solution with a concentration of 1mol / L, stir for 20min, add 0.3 parts of thioglycolic acid, keep the pH value constant, continue stirring for 20min, add 65 parts with a concentration of 8.2 ×10 - 4 mol / L potassium tellurite solution and 12 parts of sodium borohydride, keep the pH value constant, stir for 20 minutes, reflux the reaction system at 115°C for 35 minutes to obtain the CdTe quantum dot precursor suspension, and store it at 4°C; The concentration of 90 parts is 4.6×10 -2 mol / L CaCl 2 Solution, with a concentration of 1mol / L NaOH solution to adjust its pH value to 10.3, heated in a water bath at 66°C and continued to stir, and added 90 parts with a concentration of 2.8×10 -2 mol / L Na 2 HPO 4 Solution, keep ...

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PUM

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Abstract

The invention discloses a preparation method of a cadmium telluride quantum dot doped hydroxyapatite fluorescent probe. The preparation method comprises the following steps: preparing a cadmium acetate solution, adjusting the pH value to 10.8-11.2 by using a NaOH solution, stirring, adding thioglycollic acid, stirring, adding a potassium tellurite solution and sodium borohydride, stirring, and reacting at 105-115 DEG C for 25-35 minutes to obtain a CdTe quantum dot precursor suspension; preparing a CaCl2 solution, adjusting the pH value to 10.1-10.3, heating in a water bath at 64-66 DEG C, stirring, adding a Na2HPO4 solution, and stirring for 40-50 minutes; and adding the synthesized CdTe quantum dot precursor into a reaction system, maintaining the reaction condition unchanged, stirring for 2.5-3.5 h, standing, washing, centrifuging, and freeze-drying to obtain the CdTe quantum dot. The probe prepared by the method has high fluorescence intensity and is an ideal material for detectingthe concentration of copper ions.

Description

technical field [0001] The invention relates to a method for preparing a cadmium telluride quantum dot-doped hydroxyapatite fluorescent probe. Background technique [0002] Copper is an essential trace element for the human body and other animals. An appropriate amount of copper ions plays an important role in many life activities. However, excessive copper ions may cause high toxicity to organisms, and even cause damage to the central nervous system, leading to some diseases , such as Wilson disease, Alzheimer's disease, amyotrophic lateral sclerosis and prion disease, gastrointestinal dysfunction and liver and kidney damage. Therefore, it is of great significance to find a fast, sensitive and simple method for the detection of copper ions. Traditional methods for the determination of copper ions include spectrophotometry, atomic absorption spectrometry, and inductively coupled plasma-mass spectrometry, etc., but the detection process of the above methods is relatively com...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C09K11/71G01N21/64
CPCC09K11/883G01N21/6428G01N21/643
Inventor 不公告发明人
Owner 启东润博园区管理服务有限公司