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T1-MRI and optoacoustic bimodal imaging contrast agent and preparation method thereof

A dual-modal imaging and contrast agent technology, applied in the fields of nanomaterials and biomedicine, can solve the problems of hidden safety hazards, high cost, complicated preparation, etc. Effect

Inactive Publication Date: 2020-06-05
FUDAN UNIV SHANGHAI CANCER CENT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

For example, a modified gold nanorod @gadolinium oxysulfide and its preparation method invented by Yang Huanghao et al. (Application No.: CN 201710418492.X) and "a gold gadolinium composite nanomaterial, its preparation method and its use" invented by Chen Chunying et al. ( Application number: CN201511031874.4), etc. are all Gd-based materials as reagents for T1-MRI imaging. The preparation of these two multi-mode contrast agents is relatively complicated and the cost is relatively high
The "Synthesis method of Gd:CuS mineralized influenza virus visualization-guided tumor combined immunotherapy nano-preparation (application number: 201910379498.X)" invented by Zheng Bin et al. is a one-step method that can be used for T1-MRI and light A dual-mode contrast agent for acoustic imaging, but this agent also contains Gd ions, which may cause nephrotoxicity and bring safety hazards when used

Method used

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  • T1-MRI and optoacoustic bimodal imaging contrast agent and preparation method thereof
  • T1-MRI and optoacoustic bimodal imaging contrast agent and preparation method thereof
  • T1-MRI and optoacoustic bimodal imaging contrast agent and preparation method thereof

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Embodiment 1

[0041] A contrast agent for T1-MRI and photoacoustic dual-mode imaging, the preparation steps are as follows:

[0042](1) Preparation of Fe precursor solution: 50 mg of polyvinylpyrrolidone (molecular weight: 29000) was dissolved in 7 mL of deionized water, and magnetically stirred to obtain a transparent aqueous solution of polyvinylpyrrolidone. Subsequently, an equal volume of 0.03 mM ferric chloride solution was added, and the stirring was continued for 1 hour to obtain an Fe precursor solution.

[0043] (2) Preparation of ellagic acid precursor: Take 0.604 g of ellagic acid, add it into 100 mL of deionized water, stir it magnetically, and prepare a 20 mM ellagic acid precursor solution under the condition of ultrasonic assistance.

[0044] (3) Under the condition of magnetic stirring, take 1 mL of the ellagic acid precursor solution, slowly add it dropwise into the Fe precursor solution, and react for 2 hours. After the reaction, centrifuge ultrafiltration to remove the u...

Embodiment 2

[0053] A contrast agent for T1-MRI and photoacoustic dual-mode imaging, the preparation steps are as follows:

[0054] (1) Preparation of Fe precursor solution: 50 mg of polyvinylpyrrolidone (molecular weight: 29000) was dissolved in 7 mL of deionized water, and magnetically stirred to obtain a transparent aqueous solution of polyvinylpyrrolidone. Subsequently, an equal volume of 0.03 mM ferric chloride solution was added, and the stirring was continued for 1 hour to obtain an Fe precursor solution.

[0055] (2) Preparation of ellagic acid precursor: Take 0.604 g of ellagic acid, add it into 100 mL of deionized water, stir it magnetically, and prepare a 20 mM ellagic acid precursor solution under the condition of ultrasonic assistance.

[0056] (3) Under the condition of magnetic stirring, take 0.5 mL of the ellagic acid precursor solution, slowly add it dropwise into the Fe precursor solution, and react for 1 hour. After the reaction, centrifuge ultrafiltration to remove the...

Embodiment 3

[0058] A contrast agent for T1-MRI and photoacoustic dual-mode imaging, the preparation steps are as follows:

[0059] (1) Preparation of Fe precursor solution: 50 mg of polyvinylpyrrolidone (molecular weight: 29000) was dissolved in 7 mL of deionized water, and magnetically stirred to obtain a transparent aqueous solution of polyvinylpyrrolidone. Subsequently, an equal volume of 0.03 mM ferric sulfate solution was added, and the stirring was continued for 1 hour to obtain an Fe precursor solution.

[0060] (2) Preparation of ellagic acid precursor: Take 0.604 g of ellagic acid, add it into 100 mL of deionized water, stir magnetically, and prepare a 20 mM ellagic acid precursor solution under the condition of ultrasonic assistance.

[0061] (3) Under the condition of magnetic stirring, take 1 mL of the ellagic acid precursor solution, slowly add it dropwise into the Fe precursor solution, and react for 2 hours. After the reaction, centrifuge ultrafiltration to remove the unre...

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Abstract

The invention relates to a T1-MRI and optoacoustic bimodal imaging contrast agent and a preparation method thereof. The contrast agent consists of ellagic acid, ferrum and polyvinylpyrrolidone, wherein the polyvinylpyrrolidone as a surfactant can control the particle diameter of an ellagic acid-ferrum coordination polymer and improve the water solubility of the ellagic acid-ferrum coordination polymer. The longitudinal relaxation rate of the ellagic acid-ferrum coordination polymer is 2.47mM-1S-1, which is apparently higher than that of ferrum coordination compound type contrast agents which are reported at present, and the contrast agent disclosed by the invention has excellent T1-MRI radiography. What's more, the polymer has strong near-infrared absorption properties as well, has excellent optothermal conversion properties, and presents obvious near infrared optoacoustic radiography properties. The reagent concurrently has T1-MRI radiography and optoacoustic radiography functions atthe same time, a necessary bimodal contrast agent can be provided for union of MRI and optothermal radiography techniques, and the diagnosing accuracy can be improved. Therefore, the bimodal contrastagent has good clinical application prospects.

Description

technical field [0001] The invention relates to the fields of nanomaterials and biomedicine, in particular to a contrast agent for T1-MRI and photoacoustic dual-mode imaging and a preparation method thereof. Background technique [0002] At present, malignant tumors are still the main diseases that threaten human life and health. Therefore, early diagnosis and treatment of tumors are particularly important. However, a single imaging method always has inherent advantages and disadvantages. For example, magnetic resonance imaging (MRI) is a non-invasive early diagnosis method with unlimited penetration depth. It is a medical upgrade that is widely used in clinical practice. Among them, T1-weighted MRI imaging technology is a positive imaging technology, which can make relevant lesions show bright changes, and can better distinguish bones and soft tissues, and is very popular among clinicians. However, the sensitivity of T1-weighted MRI is poor, and it cannot effectively disti...

Claims

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Application Information

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IPC IPC(8): A61K49/00A61K49/10A61K49/12A61K49/22
CPCA61K49/0002A61K49/225A61K49/126A61K49/10
Inventor 宋少莉田启威
Owner FUDAN UNIV SHANGHAI CANCER CENT
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