Artificial skin and preparation method and application thereof
A technology of artificial skin and curing treatment, which is applied in the field of medical devices, can solve the problems of unstable silicone rubber film thickness, prone to cavities in the affected area, and difficult to repeat, and achieve excellent biological safety, shorten production steps, and save costs.
Active Publication Date: 2020-06-05
TIANXINFU (BEIJING) MEDICAL APPLIANCE CO LTD
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Problems solved by technology
The disadvantage of this method is that the operation process is difficult to repeat, and the thickness of the silicone rubber film is unstable.
If the two layers of the above-mentioned artificial skin are not firmly bonded, cavities are likely to be formed in the affected area during use, thus causing infection
Method used
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Embodiment 1
[0047] Embodiment 1, a kind of preparation method of artificial skin
[0048] 1. Collagen membrane preparation
[0049] Dissolve 5.0 g of type I collagen from bovine Achilles tendon in 1000 mL of acetic acid solution with a pH value of 2.5, and prepare a collagen solution through mechanical stirring; add chondroitin sulfate with a final concentration of 10%, and mix well. The uniformly mixed slurry is freeze-dried to obtain a collagen film with a three-dimensional pore structure. The thickness of the collagen film was controlled at 2.5 mm.
[0050] 2. Artificial skin preparation
[0051] 1. The two-phase addition type room temperature curing silicone rubber components (monovinyl-terminated dimethyl (siloxane and polysiloxane) (A), 1,1,1-trimethyl-N-( Trimethylsilyl)-silylamine with silica hydrolyzate (B), dimethylmethylhydrogen (siloxane and polysiloxane) (C), platinum metal complex (i.e. a platinum catalyst ) and (D)) were mixed according to the two ratios (Table 1), and ...
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Abstract
The invention discloses an artificial skin and a preparation method and application thereof. The preparation method includes the steps that S1, liquid silicone rubber is uniformly coated on the surface of a solid-phase support object, and first curing treatment is carried out to form an incompletely cured silicone rubber layer; S2, a formed collagen membrane is directly placed on the surface of the incompletely cured silicone rubber layer in the step S1 to be subjected to second curing treatment, so that the silicone rubber layer is completely cured and tightly adhered to the collagen membrane; and S3, the complete cured silicone rubber layer adhered with the collagen membrane in the step S2 is separated from the solid-phase support object to obtain the artificial skin. When a silicone rubber film is prepared, the formed collagen membrane and the silicone rubber layer are directly adhered together, the production steps are shortened, and the time and cost are saved; products do not contain a binder, and the biological safety is excellent; the adhesion is firm; and quality control and industrial production of the artificial skin are facilitated, and the production efficiency is improved.
Description
technical field [0001] The invention relates to the field of medical devices, in particular to an artificial skin and its preparation method and application. Background technique [0002] The existing double-layer artificial skin with collagen layer and silicone rubber layer structure includes the outer dermis and the inner epidermis, the collagen layer is the dermis repair material, and the silicone rubber layer acts as a temporary substitute for the epidermis. After 2-3 weeks of implantation, the collagen layer degrades to form a new dermis, then remove the silicone layer, and transplant the autologous epidermis obtained from other parts of the patient on the new dermis, and finally the epidermis and the new dermis grow together completely, completing the entire recovery process . [0003] At present, the preparation methods of double-layer artificial skin with collagen layer and silicone rubber layer structure include the following several types: one is to prepare a sili...
Claims
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IPC IPC(8): A61L27/40A61L27/60A61L27/34A61L27/50
CPCA61L27/60A61L27/34A61L27/50C08L89/00C08L83/04
Inventor 陈刚张伊骁栗国贝孙冰冰
Owner TIANXINFU (BEIJING) MEDICAL APPLIANCE CO LTD