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Phospholipid complex of Tongkat Ali extract and preparation method thereof

A technology of phospholipid complexes and extracts, which can be used in drug combinations, medical preparations with inactive ingredients, and medical preparations containing active ingredients, etc., can solve the problem of low oral bioavailability, low fat water partition coefficient, and biological Chemical activity and other issues, to achieve good application prospects, high bioavailability, and the effect of improving bioavailability

Active Publication Date: 2022-04-19
TIANJIN INT JOINT ACADEMY OF BIOTECH & MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although bitternin compounds have a wide range of pharmacological effects and use values, they are highly water-soluble and low-fat-soluble chemical substances, which are planned as the third category in the biopharmaceutical classification system (BCS), with low The high lipid-water partition coefficient and short biological half-life make the oral bioavailability of this type of compound very low, thus affecting the biological activity.

Method used

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  • Phospholipid complex of Tongkat Ali extract and preparation method thereof
  • Phospholipid complex of Tongkat Ali extract and preparation method thereof
  • Phospholipid complex of Tongkat Ali extract and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Embodiment 1: Extraction and separation of Tongkat Ali

[0041] Weigh 100g of Tongkat Ali root tablets (purchased from Anguo City Qingfengtang Chinese Herbal Pieces Co., Ltd.) and place it in a 1L round bottom flask, add 5 times the volume of 10% ethanol solution, put it in a heating mantle and heat for 4h, continuously Extract 5 times, collect and combine the extracts, concentrate and dry under reduced pressure to obtain the crude extract, then use 0-100% aqueous ethanol for gradient elution, the elution flow rate is 3BV / h, collect 30% gradient eluent , and concentrated and dried under reduced pressure to obtain a dry product, collected 30% ethanol eluted fraction (hereinafter referred to as "F2", that is, the Tongkat Ali extract of the present invention), and stored at -20°C.

Embodiment 2

[0042] Embodiment 2: Extraction and separation of Tongkat Ali

[0043] Weigh 100g of Tongkat Ali root tablets into a 1L round bottom flask, add 5 times the volume of 15% ethanol solution, put it in a heating mantle and heat for 4h, extract continuously for 5 times, collect and combine the extracts, and depressurize Concentrate and dry to obtain the crude extract, and then carry out gradient elution with 0-100% aqueous ethanol, the elution flow rate is 3BV / h, collect the 25% gradient eluent, and concentrate and dry under reduced pressure to obtain a dry product, collect 25% The ethanol eluted fraction (hereinafter referred to as "F2", ie the Tongkat Ali extract of the present invention) was stored at -20°C.

Embodiment 3

[0044] Embodiment 3: Preparation of Tongkat Ali Extract (F2) Phospholipid Complex

[0045] S1, take by weighing 0.10 g of the Dongkat Ali extract (F2) of Example 1, 0.20 g of soybean lecithin, and mix the Tongkat Ali extract with the phospholipid;

[0046] S2, add absolute ethanol 5mL;

[0047] S3, reflux and stir at 40°C for 2 hours, the stirring speed is 500-800rpm, until clarification;

[0048] S4, the reaction liquid was evaporated under reduced pressure at 45° C., ethanol was removed, and after vacuum drying for 24 hours, the Tongkat Ali phospholipid complex was obtained.

[0049] The formation of the Tongkat Ali complex obtained in S4 was confirmed by differential scanning calorimetry and Fourier transform infrared spectroscopy, as shown in figure 1 and figure 2 shown.

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Abstract

The invention discloses a phospholipid compound of Tongkat Ali extract and a preparation method thereof, belonging to the technical field of natural medicine extraction and pharmaceutical preparation. A phospholipid complex of tongkat ali extract is composed of tongkat ali extract and phospholipid, and the mass ratio of tongkat ali extract and phospholipid is 1:1-1:10. The advantages of the present invention are as follows: the preparation of the Tongkat Ali extract into a phospholipid complex can significantly improve its intestinal absorption rate and improve its bioavailability. The extraction method of the invention is simple, safe and non-toxic, has high extraction rate and low cost, can prepare different types of oral solid preparations by using the phospholipid complex as a raw material, and has very good application prospects.

Description

technical field [0001] The invention relates to a phospholipid complex of Tongkat Ali extract and a preparation method thereof, belonging to the technical field of natural medicine extraction and pharmaceutical preparations. Background technique [0002] In recent years, along with the natural environment, living environment, work pressure and other factors, the infertility rate has been rising all over the world, including my country. From 1973 to 2011, the global male sperm concentration has dropped by 59.3%, and male reproductive health problems cannot be ignored. Current methods to overcome male infertility include in vitro fertilization, intratubal transfer, intracytoplasmic sperm injection, surgery, and hormone therapy. However, these methods have disadvantages such as high cost, high toxicity and side effects, and cannot be widely used. Traditional herbal medicine has been paid more and more attention due to its advantages of economy, convenience and no obvious side...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/185A61K31/366A61K47/24A61P15/08
CPCA61K36/185A61K31/366A61K47/24A61P15/08A61K2236/15A61K2236/333A61K2236/39A61K2236/55
Inventor 张博马海秋王淑艳孙志翠任剑
Owner TIANJIN INT JOINT ACADEMY OF BIOTECH & MEDICINE