Preparation method of melastoma penicillatum extract, bacteriostatic operation method and application of melastoma penicillatum extract

A technology of peony extract and operation method, applied in the direction of medical preparations containing active ingredients, plant/algae/fungus/moss components, antifungal agents, etc., can solve the problem of limited application, toxic side effects, small drug resistance, obvious Issues such as nephrotoxicity and infusion-related toxicity

Active Publication Date: 2020-06-09
HAINAN MEDICAL COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although amphotericin B is an effective bactericide, its clinical application as a routine drug is greatly limited due to its obvious nephrotoxicity and infusion-related toxicity
Triazole antifungal drugs are the largest class of antifungal drugs, ketoconazole is the first oral drug of this type, but now more effective and less toxic triazole derivatives such as fluconazole, itracon azoles, etc., but triazoles have a wide range of drug resistance
As we all know, the chemical composition and mechanism of action in medicinal plants are complex and diverse, and the toxic side effects and drug resistance of medicinal plants are generally smaller than those of western medicines. Therefore, it is urgent to find a traditional Chinese medicine extract with anti-fungal infection to solve the above technical problems

Method used

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  • Preparation method of melastoma penicillatum extract, bacteriostatic operation method and application of melastoma penicillatum extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] Melastoma genicillatum Naud. belongs to Melastomaceae (Melastomaceae) genus Melastoma. "Flora of China" records that it is only distributed in Hainan Province in China, and it is also distributed in the Philippines abroad. In existing studies, it has been found that wild peony and other plants in the genus Wild peony have effects such as treating cholera, diarrhea, persistent fever, dysentery, leucorrhea, trauma, skin diseases, etc. In the drug susceptibility test of microorganisms such as bacillus and hemolytic streptococcus, it shows a significant inhibitory effect, and many plants of the same family and genus have certain medicinal development value. However, as one of the plants of the genus P. peony, there is no relevant report on its pharmacological effects. Therefore, a preliminary study on its antibacterial effect is conducted in order to provide some reference for the research of P. peony and its genus.

[0057] 1 Test materials and equipment

[0058] 1.1 Test...

Embodiment 2

[0085] The difference between this example and Example 1 is only that: during the pretreatment, the blast drying temperature is 45°C, and the 80-mesh sieve is passed; during extraction, the amount of extraction solvent is 900mL, the soaking time is 2.5h, and the heat reflux Extract for 3 hours; for the second extraction, the amount of extraction solvent is 400mL, and the extraction time is 3 hours; the extraction solvent is 80% ethanol.

Embodiment 3

[0087] The difference between this example and Example 2 is that: during extraction, the amount of extraction solvent used for the first extraction is 1100mL, the soaking time is 3h, and the heat reflux extraction is 2.5h; during the second extraction, the amount of extraction solvent used is 600mL, The time is 2.5h; the extraction solvent is 75% ethanol.

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Abstract

The invention discloses a preparation method of a melastoma penicillatum extract, a bacteriostatic operation method and an application of the melastoma penicillatum extract. The preparation method provided by the invention can be used to obtain a water extract and an alcohol extract of melastoma penicillatum. The bacteriostatic operation method provided by the invention has the advantages of goodstrain activation effect and high bacteriostatic operation accuracy. The extract disclosed by the invention can be used for resisting fungi, and is particularly suitable for being applied to resistingcandida albicans Ca, candida tropicalis Ct, candida glabrata Cg, candida krusei Ck and candida parapsilosis Cp. The melastoma penicillatum extract provided by the invention has an obvious inhibitioneffect on candida albicans and the like, and can lay a certain foundation for research and development of melastoma penicillatum.

Description

technical field [0001] The invention relates to a preparation method, a bacteriostasis operation method and an application of an extract of Viola peony, belonging to the technical field of traditional Chinese medicine extracts. Background technique [0002] In recent years, with the increase of organ transplantation, cancer radiotherapy and chemotherapy, and AIDS patients, the long-term unreasonable application of broad-spectrum antibiotics and adrenal cortex hormones, the number of immunocompromised patients is rapidly increasing, and the morbidity and mortality of deep fungal infections continue to increase. The infection rate peaked at 7.3%. [0003] At the same time, candidiasis has become the main type of deep fungal infection. More than 200 species of Candida have been discovered and confirmed, about 10% of which can cause human infection. The retrospective analysis of deep fungal infection cases in my country in 2010 showed that Candida was the main species, account...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61P31/10
CPCA61K36/185A61K2236/331A61K2236/333A61K2236/39A61P31/10
Inventor 杨卫丽
Owner HAINAN MEDICAL COLLEGE
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