Tissue sealing agent powder and preparation process thereof, and tissue sealing agent

A sealing agent and tissue technology, applied in the field of biodegradable polymer materials, can solve the problems of inconsistent operation of the push rod, easy formation of thrombus, and blockage of the front end of the drug delivery device, so as to improve the instantaneous liquid suction ability, avoid related complications, The effect of preventing excessive formation

Active Publication Date: 2020-06-12
北京爱特康医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] At present, before clinical application, most of the wounds need to be wiped dry, and then a liquid sealant is applied; during the preparation of the liquid sealant, there are a large amount of acidic and alkaline physiological diluents, such as uneven mixing or a push rod for pushing out the liquid sealant The operation is inconsistent, and it is easy to cause irritation to the application site of the wound; the front end of the applicator of the liquid sealant is easily blocked by the solidified gel, and the same injection cannot be used multiple times in a short period of time
[0003] At present, clinical hemostatic materials have high water absorption capacity, and the hemostasis is successful within 5 minutes, but after 5 minutes or in the case of moderate, s

Method used

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  • Tissue sealing agent powder and preparation process thereof, and tissue sealing agent
  • Tissue sealing agent powder and preparation process thereof, and tissue sealing agent
  • Tissue sealing agent powder and preparation process thereof, and tissue sealing agent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] The physical melting method fully mixes PEG-SS (4, 10000Da) and 4 times the quality of PEG-SS super absorbent carboxymethyl starch sodium powder, and through granulation and other processes to obtain tissue sealant powder or hemostatic material, which is applied to animals with severe For bleeding wounds, press for 25s, solidify excess powder with physiological diluent, or rinse with a large amount of physiological diluent to stop bleeding. Physiological diluent is phosphate buffer (pH=7.4);

[0046] The preparation method of phosphate buffer solution with pH=7.4: Weigh 4.005g of sodium chloride, 0.1g of potassium chloride, 1.7907g of disodium hydrogen phosphate dodecahydrate, and 0.135g of potassium dihydrogen phosphate, and place them in a 500mL volumetric flask in turn , and then dissolved to obtain a PBS buffer solution with pH=7.4;

[0047] Tissue sealant powder (powder A + powder B): physiological diluent = 1:3.

Embodiment 2

[0049] The physical melting method fully mixes PEG-SC (2,5000Da) and 4 times the quality of PEG-SC super absorbent carboxymethyl starch sodium powder, and obtains tissue sealant powder through granulation and other processes, which is applied to severe bleeding wounds of animals. Press for 30 seconds to stop bleeding.

Embodiment 3

[0051] PEG-SPA (4, 10000Da) and 6 times the quality of PEG-SPA high water carboxymethyl starch sodium powder are fully mixed by physical melting method, and through granulation and other processes to obtain tissue sealant powder or hemostatic material, which is applied to animals with severe For bleeding wounds, press for 25s, solidify excess powder with physiological diluent, or rinse with a large amount of physiological diluent to stop bleeding. Physiological diluent is phosphate buffer (pH=7.4); tissue sealant powder (powder A+powder B): physiological diluent=1:3.

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PUM

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Abstract

The invention relates to a tissue sealing agent powder and a preparation process thereof, and a tissue sealing agent. The sealing agent powder comprises a first component and a second component, the first component is an electrophilic raw material and contains an electrophilic functional group or a physically loaded electrophilic functional group compound; the second component is a botanical biological material; and a mass ratio of the first component to the second component is 1: 1-10. The preparation method adopts a physical melting method and a fluidized bed method. According to the preparation method, high-water-absorptivity substances of the first component and the second component contain active functional groups without any other catalysts and reagents or under a condition of changing self chemical properties, and the obtained tissue sealing agent has advantages of rapid liquid absorption, a high liquid absorption capacity, a high adhesion capacity, in-vivo degradation and a light inflammatory reaction, and can be directly applied to wounds.

Description

technical field [0001] The invention belongs to the field of biodegradable polymer materials, in particular to a method for preparing an in-situ cross-linked tissue sealant powder or a hemostatic material that can be directly applied to a wet wound surface and has a strong and rapid liquid absorption capacity . Background technique [0002] At present, before clinical application, most of the wounds need to be wiped dry, and then a liquid sealant is applied; during the preparation of the liquid sealant, there are a large amount of acidic and alkaline physiological diluents, such as uneven mixing or a push rod for pushing out the liquid sealant The operation is inconsistent, and it is easy to cause irritation to the application site of the wound; the front end of the applicator of the liquid sealant is easily blocked by the solidified gel, and the same injection cannot be used multiple times in a short period of time. [0003] At present, clinical hemostatic materials have h...

Claims

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Application Information

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IPC IPC(8): A61L24/08A61L24/04A61L24/00
CPCA61L24/001A61L24/0031A61L24/0036A61L24/046A61L24/08A61L2400/04C08L3/08C08L71/02
Inventor 郝卫国
Owner 北京爱特康医疗科技有限公司
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