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Preparation method and application of lithospermum and eucalyptus oil microemulsion gel

A technology of microemulsion gel and eucalyptus oil, which is used in pharmaceutical formulations, emulsion delivery, and medical preparations with inactive ingredients, etc., to achieve obvious effects, high moisturization, and high oil content.

Inactive Publication Date: 2020-06-16
云南伦扬科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Using eucalyptus oil supplemented with vegetable oil as the active ingredient extractant of comfrey, using nonionic surfactants, anionic surfactants and polyacrylate / branched alkanes / lauryl polyoxyethylene ether polymers as emulsifiers to prepare purple Grass oil microemulsion, and then prepare microemulsion gel, used for skin antibacterial and repairing research has not been reported

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] (1) Preparation of comfrey eucalyptus oil: in parts by weight, take 100 parts of comfrey, wash them, cut them into small pieces smaller than 0.5 cm, soak them in a mixture of 650 parts of corn oil and 200 parts of eucalyptus oil at room temperature for 48 hours, filter , to get comfrey eucalyptus oil.

[0025] (2) Preparation of comfrey eucalyptus microemulsion: in parts by weight, fully mix 20 parts of glycerol and 60 parts of comfrey eucalyptus oil, then add 2 parts of sodium lauroyl sarcosinate, 5 parts of Tween-80, 100 parts of deionized water, 4 parts of Feligel 338 / 328 emulsifier, heat up to 80°C, high-shear emulsification for 30 minutes, then raise the lid of the emulsifier by 3-4cm, continue to stir for 5 minutes, and evaporate part of the water, then lower the lid of the emulsifier, cover it tightly, stir and naturally cool to room temperature, and obtain the comfrey eucalyptus leaf microemulsion.

[0026] (3) Preparation of comfrey eucalyptus oil microemulsio...

Embodiment 2

[0037] (1) Preparation of comfrey eucalyptus oil: in parts by weight, take 100 parts of comfrey, wash them, cut them into small pieces smaller than 0.5 cm, soak them in a mixture of 600 parts of olive oil and 300 parts of eucalyptus oil at room temperature for 72 hours, filter , to get comfrey eucalyptus oil.

[0038] (2) Preparation of comfrey eucalyptus microemulsion: in parts by weight, fully mix 15 parts of glycerol and 60 parts of comfrey eucalyptus oil, then add 3 parts of sodium lauroyl sarcosinate, 6 parts of Tween-80 and 100 parts of deionized water, 5 parts of Feligel 338 / 328 emulsifier, heat up to 80°C, high-shear emulsification for 25 minutes, then raise the lid of the emulsifier by 3-4cm, continue to stir for 10 minutes, and evaporate part of the water, then lower the lid of the emulsifier, cover it tightly, stir and naturally cool to room temperature, and obtain the comfrey eucalyptus leaf microemulsion.

[0039] (3) Preparation of comfrey eucalyptus oil microem...

Embodiment 3

[0046] (1) Preparation of comfrey eucalyptus oil: in parts by weight, wash 100 parts of comfrey, cut into small pieces smaller than 0.5 cm, soak in a mixture of 700 parts of peanut oil and 300 parts of eucalyptus oil at room temperature for 56 hours, filter, Obtain comfrey eucalyptus oil.

[0047] (2) Preparation of comfrey eucalyptus microemulsion: In parts by weight, 18 parts of glycerol and 60 parts of comfrey eucalyptus oil were fully mixed, and then 3 parts of sodium lauroyl sarcosinate, 7 parts of Tween-80 and 100 parts of deionized water, 6 parts of Feligel 338 / 328 emulsifier, heated to 80°C, emulsified under high shear for 28 minutes, then raised the lid of the emulsifier by 3-4cm, and continued to stir for 8 minutes. Part of the water was evaporated, and then the lid of the emulsifier was lowered, tightly closed, stirred and naturally cooled to room temperature to obtain the comfrey eucalyptus leaf microemulsion.

[0048] (3) Preparation of comfrey eucalyptus oil mic...

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PUM

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Abstract

The invention belongs to the technical field of traditional Chinese medicine preparations, and particularly relates to a preparation method and application of lithospermum and eucalyptus oil microemulsion gel. A nonionic surfactant, an anionic surfactant and a modified polyacrylic acid emulsifier are used for emulsification; an emulsification-evaporation coupling process is adopted to prepare a microemulsion with lithospermum oil content of more than 60%, the microemulsion maintains the unique color and stability of lithospermum, and then the lithospermum eucalyptus oil microemulsion gel is prepared and used for skin antibiosis and repair. The microemulsion gel prepared by the method is uniform and fine, and has obvious antibacterial, anti-inflammatory and skin repairing effects due to high oil content.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine preparations, and in particular relates to a preparation method and application of comfrey eucalyptus oil microemulsion gel. Background technique [0002] Microemulsion is a transparent or translucent, isotropic, thermodynamically stable liquid-liquid dispersion system spontaneously formed by surfactants, co-surfactants, water phase and oil phase in appropriate proportions. Microemulsions have good solubility for both water-soluble and fat-soluble drugs, can increase the solubility of poorly soluble drugs, and improve the stability of easily soluble drugs; they are suitable for oral, injection or transdermal administration. Although microemulsion is an excellent carrier for drugs, the low degree of microemulsion affects its application in external transdermal drug delivery preparations. When microemulsion preparations are used alone, it is difficult to make drugs stay on the s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/61A61K9/06A61P17/00A61P17/02A61P17/04
CPCA61K9/0014A61K9/06A61K36/30A61K36/61A61K47/32A61K2236/35A61P17/00A61P17/02A61P17/04A61K2300/00
Inventor 陈子昭杨德志杨亚玲
Owner 云南伦扬科技有限公司
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